Profiling serum immunodominance following SARS-CoV-2 primary and breakthrough infection reveals distinct variant-specific epitope usage and immune imprinting

Jeffrey Seow; George C. E. Jefferson; Michael D. Keegan; Yeuk Yau; Luke B. Snell; Katie J. Doores

doi:10.1371/journal.ppat.1012724

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Open Access

Peer-reviewed

Research Article

Profiling serum immunodominance following SARS-CoV-2 primary and breakthrough infection reveals distinct variant-specific epitope usage and immune imprinting

Jeffrey Seow,

Roles Conceptualization, Data curation, Formal analysis, Investigation, Methodology, Supervision, Writing – original draft, Writing – review & editing

Affiliation Department of Infectious Diseases, School of Immunology & Microbial Sciences, King’s College London, London, United Kingdom
⨯
George C. E. Jefferson,

Roles Formal analysis, Investigation, Methodology

Affiliation Department of Infectious Diseases, School of Immunology & Microbial Sciences, King’s College London, London, United Kingdom
⨯
Michael D. Keegan,

Roles Investigation, Methodology

Affiliation Department of Infectious Diseases, School of Immunology & Microbial Sciences, King’s College London, London, United Kingdom
⨯
Yeuk Yau,

Roles Investigation, Methodology

Affiliation Department of Infectious Diseases, School of Immunology & Microbial Sciences, King’s College London, London, United Kingdom
⨯
Luke B. Snell,

Roles Methodology, Resources

Affiliations Department of Infectious Diseases, School of Immunology & Microbial Sciences, King’s College London, London, United Kingdom, Centre for Clinical Infection and Diagnostics Research, Department of Infectious Diseases, Guy’s and St Thomas’ NHS Foundation Trust, London, United Kingdom
⨯
Katie J. Doores

Roles Conceptualization, Data curation, Formal analysis, Funding acquisition, Project administration, Supervision, Writing – original draft, Writing – review & editing

* E-mail: katie.doores@kcl.ac.uk

Affiliation Department of Infectious Diseases, School of Immunology & Microbial Sciences, King’s College London, London, United Kingdom

https://orcid.org/0000-0002-5507-1725

⨯

Profiling serum immunodominance following SARS-CoV-2 primary and breakthrough infection reveals distinct variant-specific epitope usage and immune imprinting

Jeffrey Seow,
George C. E. Jefferson,
Michael D. Keegan,
Yeuk Yau,
Luke B. Snell,
Katie J. Doores

Published: November 18, 2024
https://doi.org/10.1371/journal.ppat.1012724

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