The TPR domain of PgaA is a multifunctional scaffold that binds PNAG and modulates PgaB-dependent polymer processing

• Roland Pfoh ,

  Contributed equally to this work with: Roland Pfoh, Adithya S. Subramanian

  Roles Conceptualization, Data curation, Formal analysis, Investigation, Visualization, Writing – original draft, Writing – review & editing

  Affiliation Program in Molecular Medicine, The Hospital for Sick Children, Toronto, Ontario, Canada

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• Adithya S. Subramanian ,

  Contributed equally to this work with: Roland Pfoh, Adithya S. Subramanian

  Roles Conceptualization, Formal analysis, Investigation, Writing – original draft, Writing – review & editing

  Affiliations Program in Molecular Medicine, The Hospital for Sick Children, Toronto, Ontario, Canada, Department of Biochemistry, University of Toronto, Toronto, Ontario, Canada

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• Jingjing Huang,

  Roles Formal analysis, Investigation, Writing – original draft, Writing – review & editing

  Affiliations Program in Molecular Medicine, The Hospital for Sick Children, Toronto, Ontario, Canada, Department of Biochemistry, University of Toronto, Toronto, Ontario, Canada

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• Dustin J. Little,

  Roles Conceptualization, Investigation, Writing – review & editing

  Current address: Department of Chemistry and Biology, Ryerson University, Toronto, Ontario, Canada

  Affiliations Program in Molecular Medicine, The Hospital for Sick Children, Toronto, Ontario, Canada, Department of Biochemistry, University of Toronto, Toronto, Ontario, Canada

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• Adam Forman,

  Roles Investigation, Writing – review & editing

  Affiliation Department of Chemistry, University of Toronto, Toronto, Ontario, Canada

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• Benjamin R. DiFrancesco,

  Roles Investigation, Writing – review & editing

  Affiliation Department of Chemistry, University of Toronto, Toronto, Ontario, Canada

  ⨯
• Negar Balouchestani-Asli,

  Roles Investigation, Writing – review & editing

  Affiliation Program in Molecular Medicine, The Hospital for Sick Children, Toronto, Ontario, Canada

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• Elena N. Kitova,

  Roles Investigation, Writing – review & editing

  Affiliation Department of Chemistry, University of Alberta, Edmonton, Alberta, Canada

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• John S. Klassen,

  Roles Formal analysis, Funding acquisition, Supervision, Writing – review & editing

  Affiliation Department of Chemistry, University of Alberta, Edmonton, Alberta, Canada

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• Régis Pomès,

  Roles Funding acquisition, Supervision, Writing – review & editing

  Affiliation Program in Molecular Medicine, The Hospital for Sick Children, Toronto, Ontario, Canada

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• Mark Nitz,

  Roles Funding acquisition, Resources, Supervision, Writing – review & editing

  Affiliation Department of Chemistry, University of Toronto, Toronto, Ontario, Canada

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• P. Lynne Howell

  Roles Conceptualization, Data curation, Formal analysis, Funding acquisition, Project administration, Resources, Supervision, Writing – original draft, Writing – review & editing

  * E-mail: howell@sickkids.ca

  Affiliations Program in Molecular Medicine, The Hospital for Sick Children, Toronto, Ontario, Canada, Department of Biochemistry, University of Toronto, Toronto, Ontario, Canada

  https://orcid.org/0000-0002-2776-062X

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