Engineering selectivity of Cutibacterium acnes phages by epigenetic imprinting

Nastassia Knödlseder; Guillermo Nevot; Maria-José Fábrega; Julia Mir-Pedrol; Marta Sanvicente-García; Nil Campamà-Sanz; Bernhard Paetzold; Rolf Lood; Marc Güell

doi:10.1371/journal.ppat.1010420

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Open Access

Peer-reviewed

Research Article

Engineering selectivity of Cutibacterium acnes phages by epigenetic imprinting

Nastassia Knödlseder,

Roles Conceptualization, Data curation, Formal analysis, Investigation, Methodology, Project administration, Validation, Visualization, Writing – original draft, Writing – review & editing

Affiliation Department of Medicine and Life Sciences, Universitat Pompeu Fabra, Barcelona, Spain
⨯
Guillermo Nevot,

Roles Data curation, Formal analysis, Investigation, Software, Validation, Visualization, Writing – original draft, Writing – review & editing

Affiliation Department of Medicine and Life Sciences, Universitat Pompeu Fabra, Barcelona, Spain
⨯
Maria-José Fábrega,

Roles Data curation, Investigation, Validation, Writing – review & editing

Affiliation Department of Medicine and Life Sciences, Universitat Pompeu Fabra, Barcelona, Spain
⨯
Julia Mir-Pedrol,

Roles Formal analysis, Software, Visualization, Writing – review & editing

Affiliation Department of Medicine and Life Sciences, Universitat Pompeu Fabra, Barcelona, Spain
⨯
Marta Sanvicente-García,

Roles Formal analysis, Software, Visualization, Writing – review & editing

Affiliation Department of Medicine and Life Sciences, Universitat Pompeu Fabra, Barcelona, Spain
⨯
Nil Campamà-Sanz,

Roles Formal analysis, Software, Visualization, Writing – review & editing

Affiliation Department of Medicine and Life Sciences, Universitat Pompeu Fabra, Barcelona, Spain
⨯
Bernhard Paetzold,

Roles Methodology, Writing – review & editing

Affiliation Sbiomedic, Beerse, Belgium
⨯
Rolf Lood,

Roles Methodology, Writing – review & editing

Affiliation Division of Infection Medicine, Department of Clinical Sciences, Lund University, Lund, Sweden
⨯
Marc Güell

Roles Conceptualization, Funding acquisition, Methodology, Project administration, Resources, Supervision, Writing – review & editing

* E-mail: marc.guell@upf.edu

Affiliation Department of Medicine and Life Sciences, Universitat Pompeu Fabra, Barcelona, Spain

https://orcid.org/0000-0003-4000-7912

⨯

Engineering selectivity of Cutibacterium acnes phages by epigenetic imprinting

Nastassia Knödlseder,
Guillermo Nevot,
Maria-José Fábrega,
Julia Mir-Pedrol,
Marta Sanvicente-García,
Nil Campamà-Sanz,
Bernhard Paetzold,
Rolf Lood,
Marc Güell

Published: March 28, 2022
https://doi.org/10.1371/journal.ppat.1010420
See the preprint

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Bacteriophages
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DNA methylation
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Methylation
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Genomics
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Sequence motif analysis
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RNA sequencing
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Microbiome
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CRISPR
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