Recombinant Lloviu virus as a tool to study viral replication and host responses

Adam J. Hume; Baylee Heiden; Judith Olejnik; Ellen L. Suder; Stephen Ross; Whitney A. Scoon; Esther Bullitt; Maria Ericsson; Mitchell R. White; Jacquelyn Turcinovic; Tran T. N. Thao; Ryan M. Hekman; Joseph E. Kaserman; Jessie Huang; Konstantinos-Dionysios Alysandratos; Gabor E. Toth; Ferenc Jakab; Darrell N. Kotton; Andrew A. Wilson; Andrew Emili; Volker Thiel; John H. Connor; Gabor Kemenesi; Daniel Cifuentes; Elke Mühlberger

doi:10.1371/journal.ppat.1010268

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Open Access

Peer-reviewed

Research Article

Recombinant Lloviu virus as a tool to study viral replication and host responses

Adam J. Hume ,

Roles Conceptualization, Formal analysis, Investigation, Methodology, Project administration, Supervision, Validation, Visualization, Writing – original draft, Writing – review & editing

* E-mail: hume@bu.edu (AJH); muehlber@bu.edu (EM)

Affiliations Department of Microbiology, Boston University School of Medicine; Boston, Massachusetts, United States of America, National Emerging Infectious Diseases Laboratories, Boston University; Boston, Massachusetts, United States of America

https://orcid.org/0000-0001-8454-3472

⨯
Baylee Heiden,

Roles Investigation, Validation

Affiliations Department of Microbiology, Boston University School of Medicine; Boston, Massachusetts, United States of America, National Emerging Infectious Diseases Laboratories, Boston University; Boston, Massachusetts, United States of America

https://orcid.org/0000-0001-7087-6997

⨯
Judith Olejnik,

Roles Investigation, Validation, Visualization, Writing – review & editing

Affiliations Department of Microbiology, Boston University School of Medicine; Boston, Massachusetts, United States of America, National Emerging Infectious Diseases Laboratories, Boston University; Boston, Massachusetts, United States of America

https://orcid.org/0000-0002-1748-7981

⨯
Ellen L. Suder,

Roles Funding acquisition, Investigation, Validation, Visualization, Writing – review & editing

Affiliations Department of Microbiology, Boston University School of Medicine; Boston, Massachusetts, United States of America, National Emerging Infectious Diseases Laboratories, Boston University; Boston, Massachusetts, United States of America

https://orcid.org/0000-0001-9466-9204

⨯
Stephen Ross,

Roles Investigation, Visualization, Writing – review & editing

Affiliations Department of Microbiology, Boston University School of Medicine; Boston, Massachusetts, United States of America, National Emerging Infectious Diseases Laboratories, Boston University; Boston, Massachusetts, United States of America, Department of Biochemistry, Boston University School of Medicine; Boston, Massachusetts, United States of America
⨯
Whitney A. Scoon,

Roles Investigation

Affiliations Department of Microbiology, Boston University School of Medicine; Boston, Massachusetts, United States of America, National Emerging Infectious Diseases Laboratories, Boston University; Boston, Massachusetts, United States of America
⨯
Esther Bullitt,

Roles Funding acquisition, Investigation, Visualization

Affiliation Department of Physiology & Biophysics, Boston University School of Medicine; Boston, Massachusetts, United States of America

https://orcid.org/0000-0003-2447-6209

⨯
Maria Ericsson,

Roles Investigation, Visualization

Affiliation Department of Cell Biology, Harvard Medical School; Boston, Massachusetts, United States of America

https://orcid.org/0000-0002-4563-3683

⨯
Mitchell R. White,

Roles Investigation

Affiliations Department of Microbiology, Boston University School of Medicine; Boston, Massachusetts, United States of America, National Emerging Infectious Diseases Laboratories, Boston University; Boston, Massachusetts, United States of America
⨯
Jacquelyn Turcinovic,

Roles Data curation, Formal analysis, Investigation, Software, Visualization, Writing – review & editing

Affiliations Department of Microbiology, Boston University School of Medicine; Boston, Massachusetts, United States of America, National Emerging Infectious Diseases Laboratories, Boston University; Boston, Massachusetts, United States of America, Program in Bioinformatics, Boston University; Boston, Massachusetts, United States of America

https://orcid.org/0000-0002-7669-223X

⨯
Tran T. N. Thao,

Roles Investigation, Writing – review & editing

Affiliations Institute of Virology and Immunology (IVI); Bern, Switzerland, Department of Infectious Diseases and Pathobiology, Vetsuisse Faculty, University of Bern; Bern, Switzerland
⨯
Ryan M. Hekman,

Roles Investigation, Writing – review & editing

Affiliations Department of Biochemistry, Boston University School of Medicine; Boston, Massachusetts, United States of America, Center for Network Systems Biology, Boston University; Boston, Massachusetts, United States of America

https://orcid.org/0000-0002-2758-6131

⨯
Joseph E. Kaserman,

Roles Investigation, Writing – review & editing

Affiliations Center for Regenerative Medicine of Boston University and Boston Medical Center; Boston, Massachusetts, United States of America, The Pulmonary Center and Department of Medicine, Boston University School of Medicine; Boston, Massachusetts, United States of America

https://orcid.org/0000-0003-3334-5702

⨯
Jessie Huang,

Roles Investigation

Affiliations Center for Regenerative Medicine of Boston University and Boston Medical Center; Boston, Massachusetts, United States of America, The Pulmonary Center and Department of Medicine, Boston University School of Medicine; Boston, Massachusetts, United States of America

https://orcid.org/0000-0002-5297-3563

⨯
Konstantinos-Dionysios Alysandratos,

Roles Investigation, Writing – review & editing

Affiliations Center for Regenerative Medicine of Boston University and Boston Medical Center; Boston, Massachusetts, United States of America, The Pulmonary Center and Department of Medicine, Boston University School of Medicine; Boston, Massachusetts, United States of America
⨯
Gabor E. Toth,

Roles Resources

Affiliations Institute of Biology, Faculty of Sciences, University of Pécs, Pécs, Hungary, Szentágothai Research Centre, University of Pécs; Pécs, Hungary
⨯
Ferenc Jakab,

Roles Resources

Affiliations Institute of Biology, Faculty of Sciences, University of Pécs, Pécs, Hungary, Szentágothai Research Centre, University of Pécs; Pécs, Hungary
⨯
Darrell N. Kotton,

Roles Funding acquisition, Writing – review & editing

Affiliations Center for Regenerative Medicine of Boston University and Boston Medical Center; Boston, Massachusetts, United States of America, The Pulmonary Center and Department of Medicine, Boston University School of Medicine; Boston, Massachusetts, United States of America, Department of Pathology & Laboratory Medicine, Boston University School of Medicine, Boston Medical Center; Boston, Massachusetts, United States of America
⨯
Andrew A. Wilson,

Roles Writing – review & editing

Affiliations Center for Regenerative Medicine of Boston University and Boston Medical Center; Boston, Massachusetts, United States of America, The Pulmonary Center and Department of Medicine, Boston University School of Medicine; Boston, Massachusetts, United States of America

https://orcid.org/0000-0003-3406-9906

⨯
Andrew Emili,

Roles Writing – review & editing

Affiliations Department of Biochemistry, Boston University School of Medicine; Boston, Massachusetts, United States of America, Center for Network Systems Biology, Boston University; Boston, Massachusetts, United States of America, Department of Biology, Boston University; Boston, Massachusetts, United States of America
⨯
Volker Thiel,

Roles Resources, Writing – review & editing

Affiliations Institute of Virology and Immunology (IVI); Bern, Switzerland, Department of Infectious Diseases and Pathobiology, Vetsuisse Faculty, University of Bern; Bern, Switzerland
⨯
John H. Connor,

Roles Writing – review & editing

Affiliations Department of Microbiology, Boston University School of Medicine; Boston, Massachusetts, United States of America, National Emerging Infectious Diseases Laboratories, Boston University; Boston, Massachusetts, United States of America
⨯
Gabor Kemenesi,

Roles Funding acquisition, Resources, Writing – review & editing

Affiliations Institute of Biology, Faculty of Sciences, University of Pécs, Pécs, Hungary, Szentágothai Research Centre, University of Pécs; Pécs, Hungary
⨯
Daniel Cifuentes,

Roles Funding acquisition, Writing – review & editing

Affiliation Department of Biochemistry, Boston University School of Medicine; Boston, Massachusetts, United States of America

https://orcid.org/0000-0001-5442-4843

⨯
[ ... ],
Elke Mühlberger

Roles Conceptualization, Funding acquisition, Methodology, Project administration, Supervision, Validation, Writing – review & editing

* E-mail: hume@bu.edu (AJH); muehlber@bu.edu (EM)

Affiliations Department of Microbiology, Boston University School of Medicine; Boston, Massachusetts, United States of America, National Emerging Infectious Diseases Laboratories, Boston University; Boston, Massachusetts, United States of America

https://orcid.org/0000-0003-3547-9376

⨯
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Recombinant Lloviu virus as a tool to study viral replication and host responses

Adam J. Hume,
Baylee Heiden,
Judith Olejnik,
Ellen L. Suder,
Stephen Ross,
Whitney A. Scoon,
Esther Bullitt,
Maria Ericsson,
Mitchell R. White,
Jacquelyn Turcinovic

Published: February 4, 2022
https://doi.org/10.1371/journal.ppat.1010268

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