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Correction: Recombinant Lloviu virus as a tool to study viral replication and host responses

  • Adam J. Hume,
  • Baylee Heiden,
  • Judith Olejnik,
  • Ellen L. Suder,
  • Stephen Ross,
  • Whitney A. Scoon,
  • Esther Bullitt,
  • Maria Ericsson,
  • Mitchell R. White,
  • Jacquelyn Turcinovic,
  • Tran T. N. Thao,
  • Ryan M. Hekman,
  • Joseph E. Kaserman,
  • Jessie Huang,
  • Konstantinos-Dionysios Alysandratos,
  • Gabor E. Toth,
  • Ferenc Jakab,
  • Darrell N. Kotton,
  • Andrew A. Wilson,
  • Andrew Emili,
  • Volker Thiel,
  • John H. Connor,
  • Gabor Kemenesi,
  • Daniel Cifuentes,
  •  [ ... ],
  • Elke Mühlberger
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The x-axis label for panel D of Fig 5 is incorrect. The label should be: mAb114 concentration (μg/mL). The authors have provided a corrected version of Fig 5 here.

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Fig 5. Antiviral testing of rLLOVcomp.

(A-D) Testing antiviral compounds against rEBOV-ZsG (gray bars) and rLLOV-ZsG (green bars) in human and bat cells. Huh7 and SuBK12-08 cells were pre-treated with the indicated concentrations of remdesivir (A) or the NPC-1 inhibitor U18666A (B) for 30 minutes, or with universal interferon (U-IFN) for 18 hours (C) prior to infection with rEBOV-ZsG or rLLOV-ZsG at an MOI of 0.1. Fluorescent images were taken at 2 dpi and mean fluorescence relative to infected cells pre-treated with vehicle control are shown. (D) Neutralization assay of rEBOV-ZsG and rLLOV-ZsG at an MOI of 10 using the indicated amounts of EBOV-neutralizing antibody mAb114. Fluorescent images were taken at 2 dpi and relative percentages of infected Huh7 cells are shown. Statistical differences were determined by two-way ANOVA (Prism), *p<0.05, **p<0.01, ***p<0.001, ****p<0.0001.

https://doi.org/10.1371/journal.ppat.1010659.g001

Reference

  1. 1. Hume AJ, Heiden B, Olejnik J, Suder EL, Ross S, Scoon WA, et al. (2022) Recombinant Lloviu virus as a tool to study viral replication and host responses. PLoS Pathog 18(2): e1010268. https://doi.org/10.1371/journal.ppat.1010268 pmid:35120176