Repertoire characterization and validation of gB-specific human IgGs directly cloned from humanized mice vaccinated with dendritic cells and protected against HCMV

• Sebastian J. Theobald ,

  Roles Data curation, Formal analysis, Investigation, Methodology, Validation, Visualization, Writing – original draft preparation, Writing – review & editing

  ¶‡ These authors share first authorship on this work.

  Affiliations Clinic of Hematology, Hemostasis, Oncology and Stem Cell Transplantation, Hannover Medical School, Hannover, Germany, Laboratory of Regenerative Immune Therapies Applied, Excellence Cluster REBIRTH, Hannover Medical School, Hannover, Germany, German Centre for Infection Research (DZIF), Partner Site Hannover-Braunschweig, Hannover, Germany

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• Christoph Kreer ,

  Roles Data curation, Formal analysis, Investigation, Methodology, Software, Validation, Visualization, Writing – original draft preparation, Writing – review & editing

  ¶‡ These authors share first authorship on this work.

  Affiliations Laboratory of Experimental Immunology, Institute of Virology, Faculty of Medicine and University Hospital of Cologne, University of Cologne, Cologne, Germany, Center for Molecular Medicine Cologne (CMMC), University Hospital of Cologne, Cologne, Germany

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• Sahamoddin Khailaie,

  Roles Formal analysis, Software, Visualization, Writing – review & editing

  Affiliation Department of Systems Immunology and Braunschweig Integrated Centre of Systems Biology (BRICS), Helmholtz Centre for Infection Research, Braunschweig, Germany

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• Agnes Bonifacius,

  Roles Methodology

  Affiliation Institute of Transfusion Medicine and Transplant Engineering, Hannover Medical School, Hannover, Germany

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• Britta Eiz-Vesper,

  Roles Methodology

  Affiliation Institute of Transfusion Medicine and Transplant Engineering, Hannover Medical School, Hannover, Germany

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• Constanca Figueiredo,

  Roles Investigation, Methodology

  Affiliation Institute of Transfusion Medicine and Transplant Engineering, Hannover Medical School, Hannover, Germany

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• Michael Mach,

  Roles Methodology

  Affiliation Institute of Virology, University Erlangen-Nürnberg, Erlangen, Germany

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• Marija Backovic,

  Roles Methodology

  Affiliation Structural Virology Unit, Department of Virology, Institut Pasteur, Paris, France; CNRS UMR 3569, Paris, France

  http://orcid.org/0000-0001-8814-4428

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• Matthias Ballmaier,

  Roles Methodology

  Affiliation Research Facility Cell Sorting, Hannover Medical School, Hannover, Germany

  http://orcid.org/0000-0002-1352-5995

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• Johannes Koenig,

  Roles Investigation

  Affiliations Clinic of Hematology, Hemostasis, Oncology and Stem Cell Transplantation, Hannover Medical School, Hannover, Germany, Laboratory of Regenerative Immune Therapies Applied, Excellence Cluster REBIRTH, Hannover Medical School, Hannover, Germany, German Centre for Infection Research (DZIF), Partner Site Hannover-Braunschweig, Hannover, Germany

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• Henning Olbrich,

  Roles Investigation

  Affiliations Clinic of Hematology, Hemostasis, Oncology and Stem Cell Transplantation, Hannover Medical School, Hannover, Germany, Laboratory of Regenerative Immune Therapies Applied, Excellence Cluster REBIRTH, Hannover Medical School, Hannover, Germany, German Centre for Infection Research (DZIF), Partner Site Hannover-Braunschweig, Hannover, Germany

  http://orcid.org/0000-0003-0863-7148

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• Andreas Schneider,

  Roles Investigation

  Affiliations Clinic of Hematology, Hemostasis, Oncology and Stem Cell Transplantation, Hannover Medical School, Hannover, Germany, Laboratory of Regenerative Immune Therapies Applied, Excellence Cluster REBIRTH, Hannover Medical School, Hannover, Germany, German Centre for Infection Research (DZIF), Partner Site Hannover-Braunschweig, Hannover, Germany

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• Valery Volk,

  Roles Investigation

  Affiliations Clinic of Hematology, Hemostasis, Oncology and Stem Cell Transplantation, Hannover Medical School, Hannover, Germany, Laboratory of Regenerative Immune Therapies Applied, Excellence Cluster REBIRTH, Hannover Medical School, Hannover, Germany, German Centre for Infection Research (DZIF), Partner Site Hannover-Braunschweig, Hannover, Germany

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• Simon Danisch,

  Roles Investigation

  Affiliations Clinic of Hematology, Hemostasis, Oncology and Stem Cell Transplantation, Hannover Medical School, Hannover, Germany, Laboratory of Regenerative Immune Therapies Applied, Excellence Cluster REBIRTH, Hannover Medical School, Hannover, Germany, German Centre for Infection Research (DZIF), Partner Site Hannover-Braunschweig, Hannover, Germany

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• Lutz Gieselmann,

  Roles Investigation

  Affiliations Laboratory of Experimental Immunology, Institute of Virology, Faculty of Medicine and University Hospital of Cologne, University of Cologne, Cologne, Germany, Center for Molecular Medicine Cologne (CMMC), University Hospital of Cologne, Cologne, Germany, German Centre for Infection Research, Partner Site Bonn-Cologne, Cologne, Germany

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• Meryem Seda Ercanoglu,

  Roles Investigation

  Affiliations Laboratory of Experimental Immunology, Institute of Virology, Faculty of Medicine and University Hospital of Cologne, University of Cologne, Cologne, Germany, Center for Molecular Medicine Cologne (CMMC), University Hospital of Cologne, Cologne, Germany

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• Martin Messerle,

  Roles Conceptualization, Funding acquisition, Writing – review & editing

  Affiliations German Centre for Infection Research (DZIF), Partner Site Hannover-Braunschweig, Hannover, Germany, Instiute of Virology, Hannover Medical School, Hannover, Germany

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• Constantin von Kaisenberg,

  Roles Resources

  Affiliation Department of Obstetrics, Clinic of Gynecology and Reproductive Medicine, and Obstetrics, Hannover Medical School, Hannover, Germany

  http://orcid.org/0000-0001-5554-1937

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• Torsten Witte,

  Roles Investigation, Methodology

  Affiliation Department of Rheumatology and Immunology, Hannover Medical School, Hannover, Germany

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• Frank Klawonn,

  Roles Formal analysis, Writing – review & editing

  Affiliations Biostatistics Group, Helmholtz Centre for Infection Research, Braunschweig, Germany, Institute for Information Engineering, Ostfalia University, Wolfenbuettel, Germany

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• Michael Meyer-Hermann,

  Roles Formal analysis, Software, Supervision, Visualization, Writing – review & editing

  Affiliations Department of Systems Immunology and Braunschweig Integrated Centre of Systems Biology (BRICS), Helmholtz Centre for Infection Research, Braunschweig, Germany, Institute for Biochemistry, Biotechnology and Bioinformatics, Technische Universität Braunschweig, Braunschweig, Germany, Cluster of Excellence RESIST (EXC 2155), Hannover Medical School, Hannover, Germany

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• Florian Klein,

  Roles Conceptualization, Formal analysis, Funding acquisition, Resources, Supervision, Writing – review & editing

  Affiliations Laboratory of Experimental Immunology, Institute of Virology, Faculty of Medicine and University Hospital of Cologne, University of Cologne, Cologne, Germany, Center for Molecular Medicine Cologne (CMMC), University Hospital of Cologne, Cologne, Germany, German Centre for Infection Research, Partner Site Bonn-Cologne, Cologne, Germany

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•  [ ... ],
• Renata Stripecke

  Roles Conceptualization, Formal analysis, Funding acquisition, Project administration, Resources, Supervision, Visualization, Writing – original draft preparation, Writing – review & editing

  * E-mail: stripecke.renata@mh-hannover.de

  Affiliations Clinic of Hematology, Hemostasis, Oncology and Stem Cell Transplantation, Hannover Medical School, Hannover, Germany, Laboratory of Regenerative Immune Therapies Applied, Excellence Cluster REBIRTH, Hannover Medical School, Hannover, Germany, German Centre for Infection Research (DZIF), Partner Site Hannover-Braunschweig, Hannover, Germany

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