RD5-mediated lack of PE_PGRS and PPE-MPTR export in BCG vaccine strains results in strong reduction of antigenic repertoire but little impact on protection

• Louis S. Ates ,

  Roles Conceptualization, Data curation, Investigation, Methodology, Writing – original draft, Writing – review & editing

  * E-mail: L.S.Ates@AMC.nl (LSA); roland.brosch@pasteur.fr (RB)

  Affiliations Institut Pasteur, Unit for Integrated Mycobacterial Pathogenomics, CNRS UMR3525, Paris, France, Department of Experimental Immunology, Academic Medical Center, University of Amsterdam, Amsterdam, the Netherlands

  http://orcid.org/0000-0002-2953-8010

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• Fadel Sayes,

  Roles Formal analysis, Investigation, Resources, Writing – review & editing

  Affiliation Institut Pasteur, Unit for Integrated Mycobacterial Pathogenomics, CNRS UMR3525, Paris, France

  http://orcid.org/0000-0001-7928-6643

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• Wafa Frigui,

  Roles Data curation, Investigation, Methodology

  Affiliation Institut Pasteur, Unit for Integrated Mycobacterial Pathogenomics, CNRS UMR3525, Paris, France

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• Roy Ummels,

  Roles Investigation, Visualization

  Affiliation Department of Medical Microbiology and Infection Prevention, VU University Medical Center, Amsterdam, the Netherlands

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• Merel P. M. Damen,

  Roles Data curation, Formal analysis, Investigation, Resources

  Affiliations Institut Pasteur, Unit for Integrated Mycobacterial Pathogenomics, CNRS UMR3525, Paris, France, Section Molecular Microbiology, Amsterdam Institute of Molecules, Medicine & Systems, Vrije Universiteit, Amsterdam, the Netherlands

  http://orcid.org/0000-0003-4233-2671

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• Daria Bottai,

  Roles Investigation, Resources, Writing – review & editing

  Affiliation University of Pisa, Department of Biology, Pisa, Italy

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• Marcel A. Behr,

  Roles Data curation, Resources, Writing – review & editing

  Affiliation McGill International TB Centre, Infectious Diseases and Immunity in Global Health Program at the McGill University Health Centre Research Institute, Montreal, Canada

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• Jeroen W. J. van Heijst,

  Roles Funding acquisition, Resources, Supervision, Writing – review & editing

  Affiliation Department of Experimental Immunology, Academic Medical Center, University of Amsterdam, Amsterdam, the Netherlands

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• Wilbert Bitter,

  Roles Resources, Writing – review & editing

  Affiliations Department of Medical Microbiology and Infection Prevention, VU University Medical Center, Amsterdam, the Netherlands, Section Molecular Microbiology, Amsterdam Institute of Molecules, Medicine & Systems, Vrije Universiteit, Amsterdam, the Netherlands

  http://orcid.org/0000-0001-8347-6511

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• Laleh Majlessi,

  Roles Formal analysis, Resources, Supervision, Writing – review & editing

  Affiliation Institut Pasteur, Unit for Integrated Mycobacterial Pathogenomics, CNRS UMR3525, Paris, France

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• Roland Brosch

  Roles Conceptualization, Funding acquisition, Project administration, Writing – review & editing

  * E-mail: L.S.Ates@AMC.nl (LSA); roland.brosch@pasteur.fr (RB)

  Affiliation Institut Pasteur, Unit for Integrated Mycobacterial Pathogenomics, CNRS UMR3525, Paris, France

  http://orcid.org/0000-0003-2587-3863

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