A Neutralizing Anti-gH/gL Monoclonal Antibody Is Protective in the Guinea Pig Model of Congenital CMV Infection

Marcy R. Auerbach; Donghong Yan; Rajesh Vij; Jo-Anne Hongo; Gerald Nakamura; Jean-Michel Vernes; Y. Gloria Meng; Samantha Lein; Pamela Chan; Jed Ross; Richard Carano; Rong Deng; Nicholas Lewin-Koh; Min Xu; Becket Feierbach

doi:10.1371/journal.ppat.1004060

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Open Access

Peer-reviewed

Research Article

A Neutralizing Anti-gH/gL Monoclonal Antibody Is Protective in the Guinea Pig Model of Congenital CMV Infection

Marcy R. Auerbach,

Affiliation Department of Infectious Diseases, Genentech, South San Francisco, California, United States of America
⨯
Donghong Yan,

Affiliation Department of Translational Immunology, Genentech, South San Francisco, California, United States of America
⨯
Rajesh Vij,

Affiliation Department of Antibody Engineering, Genentech, South San Francisco, California, United States of America
⨯
Jo-Anne Hongo,

Affiliation Department of Antibody Engineering, Genentech, South San Francisco, California, United States of America
⨯
Gerald Nakamura,

Affiliation Department of Antibody Engineering, Genentech, South San Francisco, California, United States of America
⨯
Jean-Michel Vernes,

Affiliation Department of Biochemical and Cellular Pharmacology, Genentech, South San Francisco, California, United States of America
⨯
Y. Gloria Meng,

Affiliation Department of Biochemical and Cellular Pharmacology, Genentech, South San Francisco, California, United States of America
⨯
Samantha Lein,

Affiliation Department of Antibody Engineering, Genentech, South San Francisco, California, United States of America
⨯
Pamela Chan,

Affiliation Department of Biochemical and Cellular Pharmacology, Genentech, South San Francisco, California, United States of America
⨯
Jed Ross,

Affiliation Department of Biomedical Imaging, Genentech, South San Francisco, California, United States of America
⨯
Richard Carano,

Affiliation Department of Biomedical Imaging, Genentech, South San Francisco, California, United States of America
⨯
Rong Deng,

Affiliation Department of Clinical Pharmacology, Genentech, South San Francisco, California, United States of America
⨯
Nicholas Lewin-Koh,

Affiliation Department of Biostatistics, Genentech, South San Francisco, California, United States of America
⨯
Min Xu,

Affiliation Department of Translational Immunology, Genentech, South San Francisco, California, United States of America
⨯
Becket Feierbach

* E-mail: becketf@gene.com

Affiliation Department of Infectious Diseases, Genentech, South San Francisco, California, United States of America
⨯

A Neutralizing Anti-gH/gL Monoclonal Antibody Is Protective in the Guinea Pig Model of Congenital CMV Infection

Marcy R. Auerbach,
Donghong Yan,
Rajesh Vij,
Jo-Anne Hongo,
Gerald Nakamura,
Jean-Michel Vernes,
Y. Gloria Meng,
Samantha Lein,
Pamela Chan,
Jed Ross

Published: April 10, 2014
https://doi.org/10.1371/journal.ppat.1004060

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