About the Authors

Marcy R. Auerbach

Affiliation Department of Infectious Diseases, Genentech, South San Francisco, California, United States of America

Donghong Yan

Affiliation Department of Translational Immunology, Genentech, South San Francisco, California, United States of America

Rajesh Vij

Affiliation Department of Antibody Engineering, Genentech, South San Francisco, California, United States of America

Jo-Anne Hongo

Affiliation Department of Antibody Engineering, Genentech, South San Francisco, California, United States of America

Gerald Nakamura

Affiliation Department of Antibody Engineering, Genentech, South San Francisco, California, United States of America

Jean-Michel Vernes

Affiliation Department of Biochemical and Cellular Pharmacology, Genentech, South San Francisco, California, United States of America

Y. Gloria Meng

Affiliation Department of Biochemical and Cellular Pharmacology, Genentech, South San Francisco, California, United States of America

Samantha Lein

Affiliation Department of Antibody Engineering, Genentech, South San Francisco, California, United States of America

Pamela Chan

Affiliation Department of Biochemical and Cellular Pharmacology, Genentech, South San Francisco, California, United States of America

Jed Ross

Affiliation Department of Biomedical Imaging, Genentech, South San Francisco, California, United States of America

Richard Carano

Affiliation Department of Biomedical Imaging, Genentech, South San Francisco, California, United States of America

Rong Deng

Affiliation Department of Clinical Pharmacology, Genentech, South San Francisco, California, United States of America

Nicholas Lewin-Koh

Affiliation Department of Biostatistics, Genentech, South San Francisco, California, United States of America

Min Xu

Affiliation Department of Translational Immunology, Genentech, South San Francisco, California, United States of America

Becket Feierbach

becketf@gene.com

Affiliation Department of Infectious Diseases, Genentech, South San Francisco, California, United States of America

Competing Interests

I have read the journal's policy and have the following conflicts: this research was funded by Genentech, Inc./Hoffmann La-Roche. This does not alter our adherence to all PLOS policies on sharing data and materials.

Author Contributions

Conceived and designed the experiments: MRA DY MX BF. Performed the experiments: MRA DY RV GN JMV SL PC JR RC RD. Analyzed the data: MRA PC JMV YGM JAH NLK MX BF. Contributed reagents/materials/analysis tools: MRA RV JAH GN SL. Wrote the paper: MRA BF.