MHC Class I Bound to an Immunodominant Theileria parva Epitope Demonstrates Unconventional Presentation to T Cell Receptors

Isabel K. Macdonald; Maria Harkiolaki; Lawrence Hunt; Timothy Connelley; A. Victoria Carroll; Niall D. MacHugh; Simon P. Graham; E. Yvonne Jones; W. Ivan Morrison; Darren R. Flower; Shirley A. Ellis

doi:10.1371/journal.ppat.1001149

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Peer-reviewed

Research Article

MHC Class I Bound to an Immunodominant Theileria parva Epitope Demonstrates Unconventional Presentation to T Cell Receptors

Isabel K. Macdonald ,

Contributed equally to this work with: Isabel K. Macdonald, Maria Harkiolaki

Affiliation The Jenner Institute, University of Oxford, Compton, Berkshire, United Kingdom
⨯
Maria Harkiolaki ,

Contributed equally to this work with: Isabel K. Macdonald, Maria Harkiolaki

* E-mail: maria@strubi.ox.ac.uk (MH, for structural data); shirley.ellis@bbsrc.ac.uk (SAE)

Affiliation Division of Structural Biology, Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, United Kingdom
⨯
Lawrence Hunt,

Affiliation Institute for Animal Health, Compton, Berkshire, United Kingdom
⨯
Timothy Connelley,

Affiliation The Roslin Institute, Royal (Dick) School of Veterinary Sciences, University of Edinburgh, Edinburgh, United Kingdom
⨯
A. Victoria Carroll,

Affiliation The Roslin Institute, Royal (Dick) School of Veterinary Sciences, University of Edinburgh, Edinburgh, United Kingdom
⨯
Niall D. MacHugh,

Affiliation The Roslin Institute, Royal (Dick) School of Veterinary Sciences, University of Edinburgh, Edinburgh, United Kingdom
⨯
Simon P. Graham,

Affiliation Veterinary Laboratories Agency, Addlestone, Surrey, United Kingdom
⨯
E. Yvonne Jones,

Affiliation Division of Structural Biology, Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, United Kingdom
⨯
W. Ivan Morrison ,

¶These authors also contributed equally to this work.

Affiliation The Roslin Institute, Royal (Dick) School of Veterinary Sciences, University of Edinburgh, Edinburgh, United Kingdom
⨯
Darren R. Flower ,

¶These authors also contributed equally to this work.

Affiliation The Jenner Institute, University of Oxford, Compton, Berkshire, United Kingdom
⨯
Shirley A. Ellis

* E-mail: maria@strubi.ox.ac.uk (MH, for structural data); shirley.ellis@bbsrc.ac.uk (SAE)

¶These authors also contributed equally to this work.

Affiliation Institute for Animal Health, Compton, Berkshire, United Kingdom
⨯

MHC Class I Bound to an Immunodominant Theileria parva Epitope Demonstrates Unconventional Presentation to T Cell Receptors

Isabel K. Macdonald,
Maria Harkiolaki,
Lawrence Hunt,
Timothy Connelley,
A. Victoria Carroll,
Niall D. MacHugh,
Simon P. Graham,
E. Yvonne Jones,
W. Ivan Morrison,
Darren R. Flower

Published: October 14, 2010
https://doi.org/10.1371/journal.ppat.1001149

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Major histocompatibility complex
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MHC class I genes
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