About the Authors

Isabel K. Macdonald

Contributed equally to this work with: Isabel K. Macdonald, Maria Harkiolaki

Affiliation The Jenner Institute, University of Oxford, Compton, Berkshire, United Kingdom

Maria Harkiolaki

Contributed equally to this work with: Isabel K. Macdonald, Maria Harkiolaki

maria@strubi.ox.ac.uk (MH, for structural data); shirley.ellis@bbsrc.ac.uk (SAE)

Affiliation Division of Structural Biology, Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, United Kingdom

Lawrence Hunt

Affiliation Institute for Animal Health, Compton, Berkshire, United Kingdom

Timothy Connelley

Affiliation The Roslin Institute, Royal (Dick) School of Veterinary Sciences, University of Edinburgh, Edinburgh, United Kingdom

A. Victoria Carroll

Affiliation The Roslin Institute, Royal (Dick) School of Veterinary Sciences, University of Edinburgh, Edinburgh, United Kingdom

Niall D. MacHugh

Affiliation The Roslin Institute, Royal (Dick) School of Veterinary Sciences, University of Edinburgh, Edinburgh, United Kingdom

Simon P. Graham

Affiliation Veterinary Laboratories Agency, Addlestone, Surrey, United Kingdom

E. Yvonne Jones

Affiliation Division of Structural Biology, Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, United Kingdom

W. Ivan Morrison

These authors also contributed equally to this work.

Affiliation The Roslin Institute, Royal (Dick) School of Veterinary Sciences, University of Edinburgh, Edinburgh, United Kingdom

Darren R. Flower

These authors also contributed equally to this work.

Affiliation The Jenner Institute, University of Oxford, Compton, Berkshire, United Kingdom

Shirley A. Ellis

maria@strubi.ox.ac.uk (MH, for structural data); shirley.ellis@bbsrc.ac.uk (SAE)

These authors also contributed equally to this work.

Affiliation Institute for Animal Health, Compton, Berkshire, United Kingdom

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: DRF SAE. Performed the experiments: IKM AVC NDM. Analyzed the data: IKM MH SPG EYJ. Contributed reagents/materials/analysis tools: LH TC SPG WIM. Wrote the paper: IKM MH EYJ WIM SAE. Senior crystallographer: MH. Contributed expertise in protein purification: LH.