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Ras signaling

SNAI2 cooperates with MEK1/2 and HDACs to suppress BIM- and BMF-dependent apoptosis in TERT promoter mutant cancers

Amol Tandon, Josh Lewis Stern

published 25 Jun 2025

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Network study of miRNA regulating traumatic heterotopic ossification

Kun Lian, Zhiyan Chen, Leijie Chen, Yongmei Li, Luping Liu

published 11 Feb 2025

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Rabex-5 E3 and Rab5 GEF domains differ in their regulation of Ras, Notch, and PI3K signaling in Drosophila wing development

Theresa A. Reimels, Mia Steinberg, Hua Yan, Sivan Shahar, Ashley Rosenberg, Kristina Kalafsky, Max Luf, Lindsay Kelly, Stacia Octaviani, Cathie M. Pfleger

published 28 Oct 2024

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Treatment of a mutant KRAS lung cancer cell line with polyisoprenylated cysteinyl amide inhibitors activates the MAPK pathway, inhibits cell migration and induces apoptosis

Matthew D. Gregory, Kweku Ofosu-Asante, Jassy Mary S. Lazarte, Pablo E. Puente, Nada Tawfeeq, Nadine Belony, Yong Huang, Ite A. Offringa, Nazarius S. Lamango

published 22 Oct 2024

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Autophagy-associated biomarkers ULK2, UVRAG, and miRNAs miR-21, miR-126, and miR-374: Prognostic significance in glioma patients

Wajiha Amin, Syed Ather Enam, Sufiyan Sufiyan, Kulsoom Ghias, Mohammad Hamza Bajwa, Sahar Ilyas, Altaf Ali Laghari, Sana Naeem, Syed Hani Abidi, Nouman Mughal

published 30 Sep 2024

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CBL mutations in chronic myelomonocytic leukemia often occur in the RING domain with multiple subclones per patient: Implications for targeting

Kelly Lim, Winnie L. Kan, Pramod C. Nair, Monika Kutyna, Angel F. Lopez, Timothy Hercus, David M. Ross, Steven Lane, Chun Yew Fong, Anna Brown, Agnes Yong, David Yeung, Timothy Hughes, Devendra Hiwase, Daniel Thomas

published 19 Sep 2024

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A semantics, energy-based approach to automate biomodel composition

Niloofar Shahidi, Michael Pan, Kenneth Tran, Edmund J. Crampin, David P. Nickerson

published 03 Jun 2022

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Potential of phenothiazines to synergistically block calmodulin and reactivate PP2A in cancer cells

Ganesh Babu Manoharan, Sunday Okutachi, Daniel Abankwa

published 26 May 2022

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Pentoxifylline-induced protein expression change in RAW 264.7 cells as determined by immunoprecipitation-based high performance liquid chromatography

Mi Hyun Seo, Dae Won Kim, Yeon Sook Kim, Suk Keun Lee

published 25 Mar 2022

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Network pharmacology and molecular docking reveal the effective substances and active mechanisms of Dalbergia Odoriferain protecting against ischemic stroke

Kedi Liu, Xingru Tao, Jing Su, Fei Li, Fei Mu, Shi Zhao, Xinming Lu, Jing Li, Sha Chen, Taiwei Dong, Jialin Duan, Peifeng Wei, Miaomiao Xi

published 28 Sep 2021

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Role of Ras in regulation of intestinal epithelial cell homeostasis and crosstalk with Wnt signaling

Takenori Kotani, Noriko Ihara, Saki Okamoto, Jajar Setiawan, Tasuku Konno, Yasuyuki Saito, Yoji Murata, Takashi Matozaki

published 26 Aug 2021

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Inhibition of PI3K and MAPK pathways along with KIT inhibitors as a strategy to overcome drug resistance in gastrointestinal stromal tumors

Anu Gupta, Shuang Ma, Kepeng Che, Ajaybabu V. Pobbati, Brian P. Rubin

published 29 Jul 2021

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Extracellular vesicle-enriched miRNA profiles across pregnancy in the MADRES cohort

Helen Bermudez Foley, Caitlin G. Howe, Sandrah P. Eckel, Thomas Chavez, Lili Gevorkian, Eileen Granada Reyes, Bethany Kapanke, Danilo Martinez, Shanyan Xue, Shakira F. Suglia, Theresa M. Bastain, Carmen Marsit, Carrie V. Breton

published 12 May 2021

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