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Protein engineering

Engineering of Three-Finger Fold Toxins Creates Ligands with Original Pharmacological Profiles for Muscarinic and Adrenergic Receptors

Carole Fruchart-Gaillard, Gilles Mourier, [ ... ], Denis Servent

Circular Permutation in the Ω-Loop of TEM-1 β-Lactamase Results in Improved Activity and Altered Substrate Specificity

Gurkan Guntas, Manu Kanwar, Marc Ostermeier

SMOOT libraries and phage-induced directed evolution of Cas9 to engineer reduced off-target activity

Derek Cerchione, Katherine Loveluck, [ ... ], Barrett E. Steinberg

An Automated Flow for Directed Evolution Based on Detection of Promiscuous Scaffolds Using Spatial and Electrostatic Properties of Catalytic Residues

Sandeep Chakraborty

Fluorinated oil-surfactant mixtures with the density of water: Artificial cells for synthetic biology

Roberto Laos, Steven Benner

Substrate structure and computation guided engineering of a lipase for omega-3 fatty acid selectivity

Tushar Ranjan Moharana, Nalam Madhusudhana Rao

Specific Internalisation of Gold Nanoparticles into Engineered Porous Protein Cages via Affinity Binding

David Paramelle, Tao Peng, [ ... ], Nikodem Tomczak

Fn3 proteins engineered to recognize tumor biomarker mesothelin internalize upon binding

Allison R. Sirois, Daniela A. Deny, [ ... ], Sarah J. Moore

Directed Evolution of the Transcriptional Regulator DntR: Isolation of Mutants with Improved DNT-Response

Rosa Lönneborg, Edina Varga, Peter Brzezinski

Simultaneous prediction of antibody backbone and side-chain conformations with deep learning

Deniz Akpinaroglu, Jeffrey A. Ruffolo, Sai Pooja Mahajan, Jeffrey J. Gray

Engineering of long-acting human growth hormone-Fc fusion proteins: Effects of valency, fusion position, and linker design on pharmacokinetics and efficacy

Taekyeol Lee, Dongsop Lee, [ ... ], Jaehoon Choi

Lysine Decarboxylase with an Enhanced Affinity for Pyridoxal 5-Phosphate by Disulfide Bond-Mediated Spatial Reconstitution

Hye-Young Sagong, Kyung-Jin Kim

Directed evolution provides insight into conformational substrate sampling by SrtA

Muna Suliman, Vishaka Santosh, [ ... ], William A. Barton

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