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Protein engineering

Substrate structure and computation guided engineering of a lipase for omega-3 fatty acid selectivity

Tushar Ranjan Moharana, Nalam Madhusudhana Rao

published 09 Apr 2020

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Bottom-up synthesis of protein-based nanomaterials from engineered β-solenoid proteins

Zeyu Peng, Maria D. R. Peralta, Daniel L. Cox, Michael D. Toney

published 21 Feb 2020

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Antibody engineering to generate SKY59, a long-acting anti-C5 recycling antibody

Zenjiro Sampei, Kenta Haraya, Tatsuhiko Tachibana, Taku Fukuzawa, Meiri Shida-Kawazoe, Siok Wan Gan, Yuichiro Shimizu, Yoshinao Ruike, Shu Feng, Taichi Kuramochi, Masaru Muraoka, Takehisa Kitazawa, Yoshiki Kawabe, Tomoyuki Igawa, Kunihiro Hattori, Junichi Nezu

published 28 Dec 2018

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The scale-free nature of protein sequence space

Patrick C. F. Buchholz, Catharina Zeil, Jürgen Pleiss

published 01 Aug 2018

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Fn3 proteins engineered to recognize tumor biomarker mesothelin internalize upon binding

Allison R. Sirois, Daniela A. Deny, Samantha R. Baierl, Katia S. George, Sarah J. Moore

published 08 May 2018

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Soluble T-cell receptor design influences functional yield in an E. coli chaperone-assisted expression system

Kristin Støen Gunnarsen, Lene Støkken Høydahl, Ralf Stefan Neumann, Kaare Bjerregaard-Andersen, Nicolay Rustad Nilssen, Ludvig Magne Sollid, Inger Sandlie, Geir Åge Løset

published 12 Apr 2018

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ProtDataTherm: A database for thermostability analysis and engineering of proteins

Hassan Pezeshgi Modarres, Mohammad R. Mofrad, Amir Sanati-Nezhad

published 29 Jan 2018

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An L213A variant of β-glycosidase from Sulfolobus solfataricus with increased α-L-arabinofuranosidase activity converts ginsenoside Rc to compound K

Ji-Hyeon Choi, Kyung-Chul Shin, Deok-Kun Oh

published 11 Jan 2018

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Screening of transporters to improve xylodextrin utilization in the yeast Saccharomyces cerevisiae

Chenlu Zhang, Ligia Acosta-Sampson, Vivian Yaci Yu, Jamie H. D. Cate

published 08 Sep 2017

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Directed evolution provides insight into conformational substrate sampling by SrtA

Muna Suliman, Vishaka Santosh, Tom C. M. Seegar, Annamarie C. Dalton, Kathryn M. Schultz, Candice S. Klug, William A. Barton

published 31 Aug 2017

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Directed evolution to improve the catalytic efficiency of urate oxidase from Bacillus subtilis

Wenjie Li, Shouteng Xu, Biao Zhang, Yelin Zhu, Yan Hua, Xin Kong, Lianhong Sun, Jiong Hong

published 22 May 2017

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Engineering of mCherry variants with long Stokes shift, red-shifted fluorescence, and low cytotoxicity

Yi Shen, Yingche Chen, Jiahui Wu, Nathan C. Shaner, Robert E. Campbell

published 27 Feb 2017

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Lysine Decarboxylase with an Enhanced Affinity for Pyridoxal 5-Phosphate by Disulfide Bond-Mediated Spatial Reconstitution

Hye-Young Sagong, Kyung-Jin Kim

published 17 Jan 2017

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