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Prenylation

In Vitro synergy of Farnesyltransferase inhibitors in combination with colistin against ESKAPE bacteria

Marian Klose, Lea Weber, Hagen Sjard Bachmann

published 05 Sep 2025

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Functional classification and validation of yeast prenylation motifs using machine learning and genetic reporters

Brittany M. Berger, Wayland Yeung, Arnav Goyal, Zhongliang Zhou, Emily R. Hildebrandt, Natarajan Kannan, Walter K. Schmidt

published 24 Jun 2022

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Defining substrate requirements for cleavage of farnesylated prelamin A by the integral membrane zinc metalloprotease ZMPSTE24

Kaitlin M. Wood, Eric D. Spear, Otto W. Mossberg, Kamsi O. Odinammadu, Wenxin Xu, Susan Michaelis

published 14 Dec 2020

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FTI-277 inhibits smooth muscle cell calcification by up-regulating PI3K/Akt signaling and inhibiting apoptosis

Arvind Ponnusamy, Smeeta Sinha, Gareth D. Hyde, Samantha J. Borland, Rebecca F. Taylor, Emma Pond, Heather J. Eyre, Colette A. Inkson, Andrew Gilmore, Nick Ashton, Philip A. Kalra, Ann E. Canfield

published 24 Apr 2018

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Inhibition of prenylated KRAS in a lipid environment

Johanna M. Jansen, Charles Wartchow, Wolfgang Jahnke, Susan Fong, Tiffany Tsang, Keith Pfister, Tatiana Zavorotinskaya, Dirksen Bussiere, Jan Marie Cheng, Kenneth Crawford, Yumin Dai, Jeffrey Dove, Eric Fang, Yun Feng, Jean-Michel Florent, John Fuller, Alvar D. Gossert, Mohammad Hekmat-Nejad, Chrystèle Henry, Julia Klopp, William P. Lenahan, Andreas Lingel, Sylvia Ma, Arndt Meyer, Yuji Mishina, Jamie Narberes, Gwynn Pardee, Savithri Ramurthy, Sebastien Rieffel, Darrin Stuart, Sharadha Subramanian, Laura Tandeske, Stephania Widger, Armin Widmer, Aurelie Winterhalter, Isabel Zaror, Stephen Hardy

published 06 Apr 2017

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Structural basis for non-genuine phenolic acceptor substrate specificity of Streptomyces roseochromogenes prenyltransferase CloQ from the ABBA/PT-barrel superfamily

Carla Araya-Cloutier, Bianca Martens, Gijs Schaftenaar, Franziska Leipoldt, Harry Gruppen, Jean-Paul Vincken

published 29 Mar 2017

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A Farnesyltransferase Acts to Inhibit Ectopic Neurite Formation in C. elegans

David Carr, Leticia Sanchez-Alvarez, Janice H. Imai, Cristina Slatculescu, Nathaniel Noblett, Lei Mao, Lorena Beese, Antonio Colavita

published 14 Jun 2016

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The Early-Acting Peroxin PEX19 Is Redundantly Encoded, Farnesylated, and Essential for Viability in Arabidopsis thaliana

Margaret M. McDonnell, Sarah E. Burkhart, Jerrad M. Stoddard, Zachary J. Wright, Lucia C. Strader, Bonnie Bartel

published 29 Jan 2016

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Diversity of ABBA Prenyltransferases in Marine Streptomyces sp. CNQ-509: Promiscuous Enzymes for the Biosynthesis of Mixed Terpenoid Compounds

Franziska Leipoldt, Philipp Zeyhle, Andreas Kulik, Jörn Kalinowski, Lutz Heide, Leonard Kaysser

published 14 Dec 2015

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Functional Characterization of the Vitamin K₂ Biosynthetic Enzyme UBIAD1

Yoshihisa Hirota, Kimie Nakagawa, Natsumi Sawada, Naoko Okuda, Yoshitomo Suhara, Yuri Uchino, Takashi Kimoto, Nobuaki Funahashi, Maya Kamao, Naoko Tsugawa, Toshio Okano

published 15 Apr 2015

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Towards the Systematic Mapping and Engineering of the Protein Prenylation Machinery in Saccharomyces cerevisiae

Viktor Stein, Marta H. Kubala, Jason Steen, Sean M. Grimmond, Kirill Alexandrov

published 13 Mar 2015

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Prenylation Inhibition-Induced Cell Death in Melanoma: Reduced Sensitivity in BRAF Mutant/PTEN Wild-Type Melanoma Cells

Tamás Garay, István Kenessey, Eszter Molnár, Éva Juhász, Andrea Réti, Viktória László, Anita Rózsás, Judit Dobos, Balázs Döme, Walter Berger, Walter Klepetko, József Tóvári, József Tímár, Balázs Hegedűs

published 03 Feb 2015

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Role of Protein Farnesylation in Burn-Induced Metabolic Derangements and Insulin Resistance in Mouse Skeletal Muscle

Harumasa Nakazawa, Marina Yamada, Tomokazu Tanaka, Joshua Kramer, Yong-Ming Yu, Alan J. Fischman, J. A. Jeevendra Martyn, Ronald G. Tompkins, Masao Kaneki

published 16 Jan 2015

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