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Oncogenic signaling

In-silico target prediction and pathway analysis of propranolol as a potential therapeutic agent for hepatocellular carcinoma

Ishaq Ahmad, Shakeel Ahmad Khan, Muhammad Abu Bakar, Adnan Shakoor, Abdul Wasy Zia

published 13 Feb 2026

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Blockade of interleukin-6 (IL-6) signaling in dedifferentiated liposarcoma (DDLPS) decreases mouse double minute 2 (MDM2) oncogenicity via alternative splicing

Abeba Zewdu, Danielle Braggio, Gonzalo Lopez, Kara Batte, Safiya Khurshid, Fernanda Costas C. de Faria, Hemant K. Bid, David Koller, Lucia Casadei, Katherine J. Ladner, David Wang, Valerie Grignol, O. Hans Iwenofu, Dawn Chandler, Denis C. Guttridge, Raphael E. Pollock

published 17 Sep 2025

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Integrative network toxicology and molecular docking reveal 4-Nonylphenol’s multifaceted mechanisms in breast cancer pathogenesis

Congli Jia, Fu Yang

published 09 Sep 2025

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Comparative genomic landscape of lower-grade glioma and glioblastoma

Xinxin Sun, Qingbin Jia, Kun Li, Conghui Tian, Lili Yi, Lili Yan, Juan Zheng, Xiaodong Jia, Mingliang Gu

published 29 Aug 2024

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ARID1A loss is associated with increased NRF2 signaling in human head and neck squamous cell carcinomas

Vinh Nguyen, Travis P. Schrank, Michael B. Major, Bernard E. Weissman

published 15 Feb 2024

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Oncogenic mutations in IKKβ function through global changes induced by K63-linked ubiquitination and result in autocrine stimulation

April N. Meyer, Leandro H. Gallo, Juyeon Ko, Guillermo Cardenas, Katelyn N. Nelson, Asma Siari, Alexandre R. Campos, Thomas C. Whisenant, Daniel J. Donoghue

published 18 Oct 2018

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Activation of the G_i protein-RHOA axis by non-canonical Hedgehog signaling is independent of primary cilia

Lan Ho Wei, Mohammad Arastoo, Ioanna Georgiou, David R. Manning, Natalia A. Riobo-Del Galdo

published 27 Aug 2018

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¹⁸F-FDG PET intensity correlates with a hypoxic gene signature and other oncogenic abnormalities in operable non-small cell lung cancer

Brendan T. Heiden, Guoan Chen, Matthew Hermann, Richard K. J. Brown, Mark B. Orringer, Jules Lin, Andrew C. Chang, Philip W. Carrott, William R. Lynch, Lili Zhao, David G. Beer, Rishindra M. Reddy

published 02 Jul 2018

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Comprehensive analysis of T cell leukemia signals reveals heterogeneity in the PI3 kinase-Akt pathway and limitations of PI3 kinase inhibitors as monotherapy

Olga Ksionda, Marsilius Mues, Anica M. Wandler, Lisa Donker, Milou Tenhagen, Jesse Jun, Gregory S. Ducker, Ksenia Matlawska-Wasowska, Kevin Shannon, Kevan M. Shokat, Jeroen P. Roose

published 25 May 2018

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The common oncogenomic program of NOTCH1 and NOTCH3 signaling in T-cell acute lymphoblastic leukemia

Sung Hee Choi, Eric Severson, Warren S. Pear, Xiaole S. Liu, Jon C. Aster, Stephen C. Blacklow

published 12 Oct 2017

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M-COPA suppresses endolysosomal Kit-Akt oncogenic signalling through inhibiting the secretory pathway in neoplastic mast cells

Yasushi Hara, Yuuki Obata, Keita Horikawa, Yasutaka Tasaki, Kyohei Suzuki, Takatsugu Murata, Isamu Shiina, Ryo Abe

published 12 Apr 2017

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Overexpression of NOTCH-regulated Ankyrin Repeat Protein is associated with papillary thyroid carcinoma progression

Mingdi Zhang, Yiyu Qin, Bin Zuo, Wei Gong, Shenglai Zhang, Yurong Gong, Zhiwei Quan, Bingfeng Chu

published 16 Feb 2017

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Cudraflavone C Induces Tumor-Specific Apoptosis in Colorectal Cancer Cells through Inhibition of the Phosphoinositide 3-Kinase (PI3K)-AKT Pathway

Hsien-Chuen Soo, Felicia Fei-Lei Chung, Kuan-Hon Lim, Veronica Alicia Yap, Tracey D. Bradshaw, Ling-Wei Hii, Si-Hoey Tan, Sze-Jia See, Yuen-Fen Tan, Chee-Onn Leong, Chun-Wai Mai

published 20 Jan 2017

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