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Lysosomes

St-N, a novel alkaline derivative of stevioside, reverses docetaxel resistance by targeting lysosomes in vitro and in vivo

Yanxia Guo, Shikang Wang, [ ... ], Yongqing Liu

In vitro safety evaluation of dopamine D₃R antagonist, R-VK4-116, as a potential medication for the treatment of opioid use disorder

Rahul M. Nandre, Amy Hauck Newman, Pramod S. Terse

Human iPSC-derived myelinating organoids and globoid cells to study Krabbe disease

Lisa Marie P. Evans, Joseph Gawron, [ ... ], Leandro N. Marziali

Pharmacokinetic evaluation of single-dose migalastat in non-Fabry disease subjects with ESRD receiving dialysis treatment, and use of modeling to select dose regimens in Fabry disease subjects with ESRD receiving dialysis treatment

Franklin K. Johnson, Shirley Wu, [ ... ], Anthony Sileno

An automated high-content screening and assay platform for the analysis of spheroids at subcellular resolution

Margaritha M. Mysior, Jeremy C. Simpson

Growth on stiffer substrates impacts animal health and longevity in C. elegans

Maria Oorloff, Adam Hruby, [ ... ], Ryo Higuchi-Sanabria

Gene expression analysis suggests immunosuppressive roles of endolysosomes in glioblastoma

Michael A. Sun, Haipei Yao, [ ... ], Yiping He

The N-linked glycosylation modifications in the hepatitis B surface protein impact cellular autophagy, HBV replication, and HBV secretion

Patcharin Tepjanta, Kazuhito Fujiyama, Ryo Misaki, Ingorn Kimkong

TXNIP-mediated crosstalk between oxidative stress and glucose metabolism

Stephanie Kim, Jianning Ge, [ ... ], Jae U. Jung

β2-glycoprotein I promotes the clearance of circulating mitochondria

Swapan Kumar Dasgupta, Jahnavi Gollamudi, [ ... ], Perumal Thiagarajan

Palmitoleic acid protects microglia from palmitate-induced neurotoxicity in vitro

Qingting Yu, Yanzhuo Yang, [ ... ], Falei Yuan

Trehalose enhances mitochondria deficits in human NPC1 mutant fibroblasts but disrupts mouse Purkinje cell dendritic growth ex vivo

Collin M. MacLeod, Fawad A. K. Yousufzai, [ ... ], Ileana Soto

Validation of a highly sensitive HaloTag-based assay to evaluate the potency of a novel class of allosteric β-Galactosidase correctors

Mikhail Rudinskiy, Maria Pons-Vizcarra, [ ... ], Maurizio Molinari

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