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Lysosomes

Multi-omics analysis and single-cell sequencing revealed the lysosome associated molecular subtypes and prognostic model development of papillary thyroid carcinoma

Jianhua Zhang, Kai Yue, [ ... ], Xudong Wang

Autophagy across tissues of aging mice

Julian M. Carosi, Alexis Martin, [ ... ], Timothy J. Sargeant

AAV delivery of GBA1 suppresses α-synuclein accumulation in Parkinson’s disease models and restores functions in Gaucher’s disease models

Takuro Okai, Sho Sato, [ ... ], Gabriele Proetzel

Enhanced cytotoxicity of T-DM1 in HER2-low carcinomas via autophagy inhibition

Jinghui Zhang, Xusheng Chang, [ ... ], Qun Xin

Chemigenetic Ca²⁺ indicators report elevated Ca²⁺ levels in endothelial Weibel-Palade bodies

Julian Terglane, Nicole Mertes, [ ... ], Volker Gerke

Intracerebroventricular administration of a modified hexosaminidase ameliorates late-stage neurodegeneration in a GM2 mouse model

Manuel E. Lopez, Daniel Wendt, [ ... ], Mika Aoyagi-Scharber

St-N, a novel alkaline derivative of stevioside, reverses docetaxel resistance by targeting lysosomes in vitro and in vivo

Yanxia Guo, Shikang Wang, [ ... ], Yongqing Liu

In vitro safety evaluation of dopamine D₃R antagonist, R-VK4-116, as a potential medication for the treatment of opioid use disorder

Rahul M. Nandre, Amy Hauck Newman, Pramod S. Terse

Human iPSC-derived myelinating organoids and globoid cells to study Krabbe disease

Lisa Marie P. Evans, Joseph Gawron, [ ... ], Leandro N. Marziali

Pharmacokinetic evaluation of single-dose migalastat in non-Fabry disease subjects with ESRD receiving dialysis treatment, and use of modeling to select dose regimens in Fabry disease subjects with ESRD receiving dialysis treatment

Franklin K. Johnson, Shirley Wu, [ ... ], Anthony Sileno

An automated high-content screening and assay platform for the analysis of spheroids at subcellular resolution

Margaritha M. Mysior, Jeremy C. Simpson

Growth on stiffer substrates impacts animal health and longevity in C. elegans

Maria Oorloff, Adam Hruby, [ ... ], Ryo Higuchi-Sanabria

Gene expression analysis suggests immunosuppressive roles of endolysosomes in glioblastoma

Michael A. Sun, Haipei Yao, [ ... ], Yiping He

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