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Genetically modified animals

Effects of T cell leptin signaling on systemic glucose tolerance and T cell responses in obesity

Kaitlin Kiernan, Amanda G. Nichols, Yazan Alwarawrah, Nancie J. MacIver

Mice lacking Ptprd exhibit deficits in goal-directed behavior and female-specific impairments in sensorimotor gating

Emily V. Ho, Amanda Welch, [ ... ], Stephanie C. Dulawa

A comparison of machine learning approaches for the quantification of microglial cells in the brain of mice, rats and non-human primates

Danish M. Anwer, Francesco Gubinelli, [ ... ], Andreas Heuer

Synonymous alterations of cancer-associated Trp53 CpG mutational hotspots cause fatal developmental jaw malocclusions but no tumors in knock-in mice

Richard J. Epstein, Frank P. Y. Lin, Robert A. Brink, James Blackburn

Preclinical trials in Alzheimer’s disease: Sample size and effect size for behavioural and neuropathological outcomes in 5xFAD mice

Mahvish Faisal, Jana Aid, [ ... ], Miriam A. Hickey

In vitro spermatogenesis in isolated seminiferous tubules of immature mice

Xuemin Feng, Takafumi Matsumura, [ ... ], Takehiko Ogawa

A seeding-based neuronal model of tau aggregation for use in drug discovery

Ines S. Amorim, Sylvie Challal, [ ... ], Patricia Machado

High signal-to-noise imaging of spontaneous and 5 ns electric pulse-evoked Ca²⁺ signals in GCaMP6f-expressing adrenal chromaffin cells isolated from transgenic mice

Ciara Viola, Thomas W. Gould, [ ... ], Gale L. Craviso

Mitotic CDK1 and 4E-BP1 II: A single phosphomimetic mutation in 4E-BP1 induces glucose intolerance in mice

Simon Cao, Michael J. Jurczak, [ ... ], Patrick S. Moore

Targeting nonsense-mediated RNA decay does not increase progranulin levels in the Grn ^R493X mouse model of frontotemporal dementia

Denise M. Smith, Michael L. Niehoff, [ ... ], Andrew D. Nguyen

Increased number of T cells and exacerbated inflammatory pathophysiology in a human IgG4 knock-in MRL/lpr mouse model

Yoshie Gon, Tsugumitsu Kandou, [ ... ], Hajime Yoshifuji

Heterozygous deletion of Gpr55 does not affect a hyperthermia-induced seizure, spontaneous seizures or survival in the Scn1a^+/^- mouse model of Dravet syndrome

Lyndsey L. Anderson, Dilara A. Bahceci, [ ... ], Jonathon C. Arnold

Direct implantation of hair-follicle-associated pluripotent (HAP) stem cells repairs intracerebral hemorrhage and reduces neuroinflammation in mouse model

Koya Obara, Kyoumi Shirai, [ ... ], Yasuyuki Amoh

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