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Genetically modified animals

Ectopic expression of Aspergillus flavus uricase and URAT1 in therapeutic cells promotes intracellular degradation of uric acid in hyperuricemic mice

Yuzhong Feng, Jiazhen Cui, [ ... ], Huipeng Chen

Dysregulated lactate metabolism synergizes with ALS genetic risk factors to accelerate motor decline

Shweta Tendulkar, Tong Wu, [ ... ], Aaron DiAntonio

Primary cilia in osteoblasts and osteocytes are required for skeletal development and mechano-adaptation

Mariana Moraes de Lima Perini, Alyssa F. Fayemi, [ ... ], Jiliang Li

A novel genetic strategy to interrogate an unknown phenotypic modifier: Sdhc KO-Robertsonian mice develop frequent thyroid abnormalities with papillary thyroid carcinoma-like features

Jean-Pierre Bayley, Heggert G. Rebel, Peter Devilee

The METTL3 inhibitor STM2457 suppresses gastric cancer progression by modulating m⁶A RNA modification

Hang Sun, Haozhi Xu, [ ... ], Chao Xu

Age-associated accumulation of carbamylation-derived products in tissues is independent from the myeloperoxidase pathway in mice

Christine Pietrement, Anaïs Okwieka, [ ... ], Stéphane Jaisson

Salt loading as a promising approach to study the dopaminergic phenotype of neurons of the supraoptic nucleus in mice

Alyona E. Bannikova, Tatiana S. Pronina, [ ... ], Michael V. Ugrumov

Mixed effects of complement in a chronic murine model of inflammatory erosive arthritis and pulmonary vascular disease

Kiana L. Chen, Stacey Duemmel, [ ... ], Homaira Rahimi

Molecular remodeling of the myocardium in mice with melanocortin-4 receptor deletion before cardiac function impairment

Xiaomei Wang, Yuanmin Qi, [ ... ], Jinxiang Yuan

PFKFB3 exacerbates myocardial injury by accelerating CXCR4^hi neutrophil mobilization after acute myocardial infarction

Yingjia Xu, Min Xiao, [ ... ], Zongying Yu

Generation and characterization of a mouse model of conditional Chd4 knockout in the endometrial epithelium

Shannon K. Harkins, Hilary J. Skalski, [ ... ], Ronald L. Chandler

Development of a floxed Gabbr2 gene allows for widespread conditional disruption of GABBR2 and recapitulates the phenotype of germline Gabbr2 knockout mice

Julie Rose Hens, Stacey Brown, [ ... ], John J. Wysolmerski

UTX/Top2β axis mediated spinal cord microvascular endothelial cells senescence exacerbates spinal cord injury

Dongliang Liu, Yudong Liu, Tianding Wu, Jianzhong Hu

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