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Electron cryo-microscopy

Conserved amino acids in the region connecting membrane spanning domain 1 to nucleotide binding domain 1 are essential for expression of the MRP1 (ABCC1) transporter

Emma E. Smith, Gwenaëlle Conseil, Susan P. C. Cole

published 11 Feb 2021

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Toward in vivo-relevant hERG safety assessment and mitigation strategies based on relationships between non-equilibrium blocker binding, three-dimensional channel-blocker interactions, dynamic occupancy, dynamic exposure, and cellular arrhythmia

Hongbin Wan, Gianluca Selvaggio, Robert A. Pearlstein

published 04 Nov 2020

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Bridging of nucleosome-proximal DNA double-strand breaks by PARP2 enhances its interaction with HPF1

Guillaume Gaullier, Genevieve Roberts, Uma M. Muthurajan, Samuel Bowerman, Johannes Rudolph, Jyothi Mahadevan, Asmita Jha, Purushka S. Rae, Karolin Luger

published 03 Nov 2020

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2.7 Å cryo-EM structure of vitrified M. musculus H-chain apoferritin from a compact 200 keV cryo-microscope

Farzad Hamdi, Christian Tüting, Dmitry A. Semchonok, Koen M. Visscher, Fotis L. Kyrilis, Annette Meister, Ioannis Skalidis, Lisa Schmidt, Christoph Parthier, Milton T. Stubbs, Panagiotis L. Kastritis

published 06 May 2020

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Structure and conformational cycle of a bacteriophage-encoded chaperonin

Andreas Bracher, Simanta S. Paul, Huping Wang, Nadine Wischnewski, F. Ulrich Hartl, Manajit Hayer-Hartl

published 27 Apr 2020

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Functional analysis of proposed substrate-binding residues of Hsp104

Matthew K. Howard, Brian S. Sohn, Julius von Borcke, Andy Xu, Meredith E. Jackrel

published 10 Mar 2020

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Cryo-electron microscopy of extracellular vesicles from cerebrospinal fluid

Anton Emelyanov, Tatiana Shtam, Roman Kamyshinsky, Luiza Garaeva, Nikolai Verlov, Irina Miliukhina, Anastasia Kudrevatykh, Gaspar Gavrilov, Yulia Zabrodskaya, Sofya Pchelina, Andrey Konevega

published 30 Jan 2020

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Upgraded molecular models of the human KCNQ1 potassium channel

Georg Kuenze, Amanda M. Duran, Hope Woods, Kathryn R. Brewer, Eli Fritz McDonald, Carlos G. Vanoye, Alfred L. George Jr., Charles R. Sanders, Jens Meiler

published 13 Sep 2019

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High-resolution cryo-EM structures of the E. coli hemolysin ClyA oligomers

Wei Peng, Marcela de Souza Santos, Yang Li, Diana R. Tomchick, Kim Orth

published 02 May 2019

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Cryo-EM Structure of HER2-trastuzumab-pertuzumab complex

Yue Hao, Xinchao Yu, Yonghong Bai, Helen J. McBride, Xin Huang

published 01 May 2019

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Nucleosome DNA unwrapping does not affect prototype foamy virus integration efficiency or site selection

Randi M. Mackler, Nathan D. Jones, Anne M. Gardner, Miguel A. Lopez Jr., Cecil J. Howard, Richard Fishel, Kristine E. Yoder

published 13 Mar 2019

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Deformed alignment of super-resolution images for semi-flexible structures

Xiaoyu Shi, Galo Garcia III, Yina Wang, Jeremy F. Reiter, Bo Huang

published 13 Mar 2019

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Structure basis of neutralization by a novel site II/IV antibody against respiratory syncytial virus fusion protein

Qingqing Xie, Zhao Wang, Fengyun Ni, Xiaorui Chen, Jianpeng Ma, Nita Patel, Hanxin Lu, Ye Liu, Jing-Hui Tian, David Flyer, Michael J. Massare, Larry Ellingsworth, Gregory Glenn, Gale Smith, Qinghua Wang

published 07 Feb 2019

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