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Electron cryo-microscopy

Exploration of a workflow for the classification and identification of co-purified protein complexes yields new structures and multiple MSP assembly states

Qingyang Zhang, Abhinandan Venkatesha Murthy, Carsten Mim

Inhibition of HER2 signaling and breast cancer cell growth with a novel antibody targeting HER2 ECD III/IV

Chunchun Liu, Yulei Ren, [ ... ], Huirong Yang

Substituted cysteine modification and protection indicates selective interactions of the anesthetic photolabel pTFD-di-iPr-BnOH with α+/β– and α+/γ– transmembrane subunit interfaces of synaptic GABA_A receptors

Kieran Bhave, Stuart A. Forman

Molecular basis for the activation of the bitter taste receptor TAS2R14 by Ritonavir

Jiao Wen, Xinyi Ma, [ ... ], Meng Cui

Navigating the unstructured by evaluating alphafold’s efficacy in predicting missing residues and structural disorder in proteins

Sen Zheng

Mechanism of connexin channel inhibition by mefloquine and 2-aminoethoxydiphenyl borate

Pia Lavriha, Yufei Han, [ ... ], Volodymyr M. Korkhov

Structural insight into the DNMT1 reaction cycle by cryo-electron microscopy

Inessa De, Jonas Weidenhausen, Nestor Concha, Christoph W. Müller

Nematocida displodere mechanosensitive ion channel of small conductance 2 assembles into a unique 6-channel super-structure in vitro

Alexandra Berg, Ronnie P.-A. Berntsson, Jonas Barandun

In silico analysis of TRPM4 variants of unknown clinical significance

Svetlana I. Tarnovskaya, Anna A. Kostareva, Boris S. Zhorov

The structure of a Type III-A CRISPR-Cas effector complex reveals conserved and idiosyncratic contacts to target RNA and crRNA among Type III-A systems

Mohammadreza Paraan, Mohamed Nasef, [ ... ], Jack A. Dunkle

CryoEM structure of a post-assembly MS-ring reveals plasticity in stoichiometry and conformation

Prashant K. Singh, Gary Cecchini, Terunaga Nakagawa, T. M. Iverson

Impact of the yeast S0/uS2-cluster ribosomal protein rpS21/eS21 on rRNA folding and the architecture of small ribosomal subunit precursors

Gisela Pöll, Joachim Griesenbeck, Herbert Tschochner, Philipp Milkereit

Cryo-electron microscopy of adipose tissue extracellular vesicles in obesity and type 2 diabetes mellitus

Valentina V. Miroshnikova, Kseniya V. Dracheva, [ ... ], Tatiana A. Shtam

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