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Electron cryo-microscopy

Conserved amino acids in the region connecting membrane spanning domain 1 to nucleotide binding domain 1 are essential for expression of the MRP1 (ABCC1) transporter

Emma E. Smith, Gwenaëlle Conseil, Susan P. C. Cole

Toward in vivo-relevant hERG safety assessment and mitigation strategies based on relationships between non-equilibrium blocker binding, three-dimensional channel-blocker interactions, dynamic occupancy, dynamic exposure, and cellular arrhythmia

Hongbin Wan, Gianluca Selvaggio, Robert A. Pearlstein

Bridging of nucleosome-proximal DNA double-strand breaks by PARP2 enhances its interaction with HPF1

Guillaume Gaullier, Genevieve Roberts, [ ... ], Karolin Luger

2.7 Å cryo-EM structure of vitrified M. musculus H-chain apoferritin from a compact 200 keV cryo-microscope

Farzad Hamdi, Christian Tüting, [ ... ], Panagiotis L. Kastritis

Structure and conformational cycle of a bacteriophage-encoded chaperonin

Andreas Bracher, Simanta S. Paul, [ ... ], Manajit Hayer-Hartl

Functional analysis of proposed substrate-binding residues of Hsp104

Matthew K. Howard, Brian S. Sohn, [ ... ], Meredith E. Jackrel

Cryo-electron microscopy of extracellular vesicles from cerebrospinal fluid

Anton Emelyanov, Tatiana Shtam, [ ... ], Andrey Konevega

Upgraded molecular models of the human KCNQ1 potassium channel

Georg Kuenze, Amanda M. Duran, [ ... ], Jens Meiler

High-resolution cryo-EM structures of the E. coli hemolysin ClyA oligomers

Wei Peng, Marcela de Souza Santos, [ ... ], Kim Orth

Cryo-EM Structure of HER2-trastuzumab-pertuzumab complex

Yue Hao, Xinchao Yu, [ ... ], Xin Huang

Nucleosome DNA unwrapping does not affect prototype foamy virus integration efficiency or site selection

Randi M. Mackler, Nathan D. Jones, [ ... ], Kristine E. Yoder

Deformed alignment of super-resolution images for semi-flexible structures

Xiaoyu Shi, Galo Garcia III, [ ... ], Bo Huang

Structure basis of neutralization by a novel site II/IV antibody against respiratory syncytial virus fusion protein

Qingqing Xie, Zhao Wang, [ ... ], Qinghua Wang

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