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DNA repair

Non-viral in vivo electroporation-based chromosomal engineering and repair assessment in the murine uterine epithelium

Satoru Iwata, Yumi Miura, Takashi Iwamoto

published 11 May 2026

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Differential sensitivity of MCPH1- and BRCA2-deficient cancer cells to PARP-1 inhibition

Isobel G. Chapman, Xueqin Wu, Stephany Veuger, Paul A. Jowsey

published 03 Apr 2026

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HIF1α mediates resistance to radiation and to KRAS inhibitors in pancreatic adenocarcinoma

Kevin J. Tu, Sanjit K. Roy, Tami J. Kingsbury, Hem D. Shukla

published 26 Mar 2026

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HMGB1 reduce DNA damage by binding KU70 to activate NHEJ pathway in colorectal cancer cells after radiation

Xiuxin Liu, Yuhui Han, Ruixue Kuang, Wenjiong Sheng, Yan Zhang, Xinyu Jia, Xiaoxiao Gao, Yanchao Ma

published 24 Mar 2026

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Differential modulation of haematopoietic and oxidative injury by PARP-1 and ATR kinase inhibition in a murine model of acute irradiation

Baydaa Taher Sih

published 06 Mar 2026

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A damage-structured PDE model of stem cell hierarchies: The dual role of dedifferentiation in tissue homeostasis and aging

Louis Shuo Wang, Jiguang Yu, Zonghao Liu

published 24 Feb 2026

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Omics-aided design genome editing strategy for challenging human immortalized cell models

Patricia Mendoza-Garcia, Benjamin Keith, Markus Nordberg, Ella Quist, Cristina Ferrás, Ghaith M. Hamza, Ramy Elgendy, Stephanie Kay Ashenden, Jordi Chi, Natalie R. van Zuydam, Neil Hattersley, Xiang Zhang

published 12 Feb 2026

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Increased sensitivity of etoposide-treated breast cancer cells with an ATM inhibitor

Arun R. K. Kumar, Crystal Sara Shaji, Aswathi Rajagopalan, Sombodhi Bhattacharya, Wilner Martínez-López, Radha Saraswathy

published 20 Jan 2026

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Predicting the influence of homologous recombination repair deficiency genes on glioma heterogeneity and patient prognosis using multi-omics analysis and machine learning

Xin Wu, Longyuan Li, Zheng Zhan, Mei Chang, Jiaxuan Li, Zhouqing Chen, Zhong Wang

published 19 Dec 2025

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In silico structural analysis of Oryza sativa RAD51 reveals key interactions for nucleoprotein filament assembly and regulation

Ayesha Azeem, Syed Farhat Ali, Rana Salman Anjum

published 12 Nov 2025

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Characterization of ORF19.7608 (PPP1), a biofilm-induced gene of Candida albicans

Nmerichukwu C. Iwuchukwu, Anna Carolina Borges Pereira da Costa, Chris Law, Min-Ju Kim, Aaron P. Mitchell, Malcolm Whiteway

published 11 Nov 2025

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PRMT5 genetic interactions with DNA double strand break repair genes

Hunter J. Bliss, Juliana Tron, Wesley Bush, Renee A. Bouley, Ruben C. Petreaca

published 09 Oct 2025

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Anti-cancer compound screening identifies Aurora Kinase A inhibition as a means to favor CRISPR/Cas9 gene correction over knock-out

Danny Wilbie, Selma Eising, Vicky Amo-Addae, Johanna Walther, Esmeralda Bosman, Zhiyong Lei, Olivier G de Jong, Jan J Molenaar, Enrico Mastrobattista

published 26 Sep 2025

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