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DNA repair

Omics-aided design genome editing strategy for challenging human immortalized cell models

Patricia Mendoza-Garcia, Benjamin Keith, Markus Nordberg, Ella Quist, Cristina Ferrás, Ghaith M. Hamza, Ramy Elgendy, Stephanie Kay Ashenden, Jordi Chi, Natalie R. van Zuydam, Neil Hattersley, Xiang Zhang

published 12 Feb 2026

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Increased sensitivity of etoposide-treated breast cancer cells with an ATM inhibitor

Arun R. K. Kumar, Crystal Sara Shaji, Aswathi Rajagopalan, Sombodhi Bhattacharya, Wilner Martínez-López, Radha Saraswathy

published 20 Jan 2026

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Predicting the influence of homologous recombination repair deficiency genes on glioma heterogeneity and patient prognosis using multi-omics analysis and machine learning

Xin Wu, Longyuan Li, Zheng Zhan, Mei Chang, Jiaxuan Li, Zhouqing Chen, Zhong Wang

published 19 Dec 2025

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In silico structural analysis of Oryza sativa RAD51 reveals key interactions for nucleoprotein filament assembly and regulation

Ayesha Azeem, Syed Farhat Ali, Rana Salman Anjum

published 12 Nov 2025

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Characterization of ORF19.7608 (PPP1), a biofilm-induced gene of Candida albicans

Nmerichukwu C. Iwuchukwu, Anna Carolina Borges Pereira da Costa, Chris Law, Min-Ju Kim, Aaron P. Mitchell, Malcolm Whiteway

published 11 Nov 2025

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PRMT5 genetic interactions with DNA double strand break repair genes

Hunter J. Bliss, Juliana Tron, Wesley Bush, Renee A. Bouley, Ruben C. Petreaca

published 09 Oct 2025

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Anti-cancer compound screening identifies Aurora Kinase A inhibition as a means to favor CRISPR/Cas9 gene correction over knock-out

Danny Wilbie, Selma Eising, Vicky Amo-Addae, Johanna Walther, Esmeralda Bosman, Zhiyong Lei, Olivier G de Jong, Jan J Molenaar, Enrico Mastrobattista

published 26 Sep 2025

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An unexpected role of CLASP1 in radiation response and S-phase regulation of head and neck cancer cells

Reinout H. de Roest, Marijke Buijze, Myrthe Veth, Klaas de Lint, Govind Pai, Martin A. Rooimans, Rob M.F. Wolthuis, Arjen Brink, Jos B. Poell, Ruud H. Brakenhoff

published 06 Aug 2025

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Premature termination of DNA Damage Repair by 3-Methyladenine potentiates cisplatin cytotoxicity in nasopharyngeal carcinoma cells

Jie Zhou, Sisi Liu, Jiali Deng, Longmei He, Binyuan Jiang

published 04 Aug 2025

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Ferrocene thiazolidine-2,4-dione derivatives cause DNA damage and interfere with DNA repair in triple-negative breast cancer cells

Nyeleti Vukea, Ogunyemi Oderinlo, Matshawandile Tukulula, Setshaba David Khanye, Adrienne Lesley Edkins, Jo-Anne de la Mare

published 17 Jul 2025

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Evaluation of subretinally delivered Cas9 ribonucleoproteins in murine and porcine animal models highlights key considerations for therapeutic translation of genetic medicines

Spencer C. Wei, Aaron J. Cantor, Jack Walleshauser, Rina Mepani, Kory Melton, Ashil Bans, Prachi Khekare, Suhani Gupta, Jonathan Wang, Craig Soares, Radwan Kiwan, Jieun Lee, Shannon McCawley, Vihasi Jani, Weng In Leong, Pawan K. Shahi, Jean Chan, Pierre Boivin, Peter Otoupal, Bikash R. Pattnaik, David M. Gamm, Krishanu Saha, Benjamin G. Gowen, Mary Haak-Frendscho, Mary J. Janatpour, Adam P. Silverman

published 24 Jun 2025

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Computational investigation unveils pathogenic LIG3 non-synonymous mutations and therapeutic targets in acute myeloid leukemia

Md. Arif Hossen, Umme Mim Sad Jahan, Md. Arju Hossain, Khalid Hossain Asif, Ahona Rahman, Sabbir Ahmed, Md. Moin Uddin, Md Faisal Amin, Muhammad Abdul Barik, Mohammod Johirul Islam, Mohammad Kamruzzaman, Soharth Hasnat, Mohammad Nasir Uddin, Tofazzal Islam, M. Nazmul Hoque

published 10 Jun 2025

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CRISPR genome editing using a combined positive and negative selection system

Ishrya Sharma, Kerisa Hall, Shannon Moonah

published 06 May 2025

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