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DNA repair

Omics-aided design genome editing strategy for challenging human immortalized cell models

Patricia Mendoza-Garcia, Benjamin Keith, [ ... ], Xiang Zhang

Increased sensitivity of etoposide-treated breast cancer cells with an ATM inhibitor

Arun R. K. Kumar, Crystal Sara Shaji, [ ... ], Radha Saraswathy

Predicting the influence of homologous recombination repair deficiency genes on glioma heterogeneity and patient prognosis using multi-omics analysis and machine learning

Xin Wu, Longyuan Li, [ ... ], Zhong Wang

In silico structural analysis of Oryza sativa RAD51 reveals key interactions for nucleoprotein filament assembly and regulation

Ayesha Azeem, Syed Farhat Ali, Rana Salman Anjum

Characterization of ORF19.7608 (PPP1), a biofilm-induced gene of Candida albicans

Nmerichukwu C. Iwuchukwu, Anna Carolina Borges Pereira da Costa, [ ... ], Malcolm Whiteway

PRMT5 genetic interactions with DNA double strand break repair genes

Hunter J. Bliss, Juliana Tron, [ ... ], Ruben C. Petreaca

Anti-cancer compound screening identifies Aurora Kinase A inhibition as a means to favor CRISPR/Cas9 gene correction over knock-out

Danny Wilbie, Selma Eising, [ ... ], Enrico Mastrobattista

An unexpected role of CLASP1 in radiation response and S-phase regulation of head and neck cancer cells

Reinout H. de Roest, Marijke Buijze, [ ... ], Ruud H. Brakenhoff

Premature termination of DNA Damage Repair by 3-Methyladenine potentiates cisplatin cytotoxicity in nasopharyngeal carcinoma cells

Jie Zhou, Sisi Liu, [ ... ], Binyuan Jiang

Ferrocene thiazolidine-2,4-dione derivatives cause DNA damage and interfere with DNA repair in triple-negative breast cancer cells

Nyeleti Vukea, Ogunyemi Oderinlo, [ ... ], Jo-Anne de la Mare

Evaluation of subretinally delivered Cas9 ribonucleoproteins in murine and porcine animal models highlights key considerations for therapeutic translation of genetic medicines

Spencer C. Wei, Aaron J. Cantor, [ ... ], Adam P. Silverman

Computational investigation unveils pathogenic LIG3 non-synonymous mutations and therapeutic targets in acute myeloid leukemia

Md. Arif Hossen, Umme Mim Sad Jahan, [ ... ], M. Nazmul Hoque

CRISPR genome editing using a combined positive and negative selection system

Ishrya Sharma, Kerisa Hall, Shannon Moonah

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