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DNA cleavage

Conversion of a telomere resolvase into a Cre-like site-specific recombinase

Shu Hui Huang, Mahrokh Balouchi, Kerri Kobryn

published 17 Jul 2025

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Enhanced thermal stability enables human mismatch-specific thymine–DNA glycosylase to catalyse futile DNA repair

Diana Manapkyzy, Botagoz Joldybayeva, Alexander A. Ishchenko, Bakhyt T. Matkarimov, Dmitry O. Zharkov, Sabira Taipakova, Murat K. Saparbaev

published 18 Oct 2024

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Design and characterization of hyperactive mutants of the Agrobacterium tumefaciens telomere resolvase, TelA

Shu Hui Huang, Kayla Abrametz, Siobhan L. McGrath, Kerri Kobryn

published 25 Jul 2024

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The telomere resolvase, TelA, utilizes an underwound pre-cleavage intermediate to promote hairpin telomere formation

Mahrokh Balouchi, Shu Hui Huang, Siobhan L. McGrath, Kerri Kobryn

published 29 Nov 2023

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Cas9 is mostly orthogonal to human systems of DNA break sensing and repair

Ekaterina A. Maltseva, Inna A. Vasil’eva, Nina A. Moor, Daria V. Kim, Nadezhda S. Dyrkheeva, Mikhail M. Kutuzov, Ivan P. Vokhtantsev, Lilya M. Kulishova, Dmitry O. Zharkov, Olga I. Lavrik

published 29 Nov 2023

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A programmable DNA roadblock system using dCas9 and multivalent target sites

Emily K. Matozel, Stephen Parziale, Allen C. Price

published 06 May 2022

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Pursuit of chlorovirus genetic transformation and CRISPR/Cas9-mediated gene editing

Eric A. Noel, Donald P. Weeks, James L. Van Etten

published 21 Oct 2021

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A single-molecule counting approach for convenient and ultrasensitive measurement of restriction digest efficiencies

Yi Zhang, Takuro Nunoura, Daisuke Nishiura, Miho Hirai, Shigeru Shimamura, Kanako Kurosawa, Chieko Ishiwata, Shigeru Deguchi

published 31 Dec 2020

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DNA binding activity of the proximal C-terminal domain of rat DNA topoisomerase IIβ is involved in ICRF-193-induced closed-clamp formation

Shinji Kawano, Kunpei Fujimoto, Kazushi Yasuda, Shogo Ikeda

published 22 Sep 2020

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A simple and affordable kinetic assay of nucleic acids with SYBR Gold gel staining

Danielle Guillen, Mika Schievelbein, Kushkumar Patel, Davis Jose, Jonathan Ouellet

published 03 Mar 2020

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Optimizing sgRNA length to improve target specificity and efficiency for the GGTA1 gene using the CRISPR/Cas9 gene editing system

Anders W. Matson, Nora Hosny, Zachary A. Swanson, Bernhard J. Hering, Christopher Burlak

published 10 Dec 2019

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Epstein-Barr virus genome packaging factors accumulate in BMRF1-cores within viral replication compartments

Atsuko Sugimoto, Yoriko Yamashita, Teru Kanda, Takayuki Murata, Tatsuya Tsurumi

published 13 Sep 2019

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Petri net–based model of the human DNA base excision repair pathway

Marcin Radom, Magdalena A. Machnicka, Joanna Krwawicz, Janusz M. Bujnicki, Piotr Formanowicz

published 13 Sep 2019

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