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Clinical trials

Restrictive versus liberal oxygenation targets in patients with acute heart failure and pulmonary congestion–A protocol for a Randomized Controlled Trial (The REDOX-AHF trial)

Ida Arentz Taraldsen, Anne Sophie Overgaard Olesen, Jasmin Dam Lukoschewitz, Ejvind Frausing Hansen, Olav Wendelboe Nielsen, Christian Hassager, Jens Jakob Thune, Maryam Noory, Arzu Karamat, Jens Dahlgaard Hove, Johannes Grand

published 22 May 2026

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Exercise-based cardiac rehabilitation and atherosclerotic plaque regression in ASCVD: Is exercise really a game-changer? A scoping review of controlled trials

Dwita Rian Desandri, Averina Octaxena Aslani, Faqrizal Ria Qhabibi, Dimitra Nikoletou

published 20 May 2026

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Spinal mechanisms and feasibility of Dry Needling versus Botulinum Toxin Type A in post-stroke lower limb spasticity: A proof-of-concept randomized clinical trial protocol (STROKE-POC)

Clara Pujol-Fuentes, Bart Eeckhaut, Samuel Fernández Carnero, Daniel Fernández Sanchís, Theodore Wein, Pablo Herrero, Wim Saeys, Mindy F. Levin

published 20 May 2026

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Maintaining function and participation through tailored 24-hour movement behaviours for people living with multiple long-term conditions and frailty (The PERSONAL-AGILITY study): Protocol for a randomised controlled feasibility trial

Martha Thomas, Louisa Y. Herring, Melanie J. Davies, Lucina Wilde, Vicky Hall, Laura J. Gray, Sharlene A. Greenwood, Michelle Hadjiconstantinou, Malak Hamza, Andrew Harris, Jemma Hawkins, Kamlesh Khunti, Matthew Maddocks, Atulkumar Rajpara, Alex Rowlands, Priscilla Sarkar, Avan A. Sayer, Sam Seidu, Tom Yates, Hannah M. L. Young

published 18 May 2026

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Autonomic nervous system modulation by G protein-biased mu-opioid receptor agonists: A translational scoping review protocol

Yi Zhang, Qiuxiang Chen, Yuanyuan Zhou, Qingjun Zeng, Haishan Cui, Yukai Zhou

published 15 May 2026

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Economic evaluation of finotonlimab plus bevacizumab as first-line therapy for advanced hepatocellular carcinoma

XueYin Xu, Lian Tang, XiangHua Piao, ShaoQing Zhan, Yong Chen, PanFeng Feng

published 14 May 2026

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The impact of walking on creative thinking: A systematic review and meta-analysis

Alex Thabane, Vikram Arora, Joelle Boilard, Adam Sutoski, Sameer Parpia, Goran Calic, Jason W. Busse, Tyler McKechnie, Phillip Staibano, Mark Phillips, Roni Reiter-Palmon, Mohit Bhandari

published 13 May 2026

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Emotion-focused therapy and forgiveness in the older population: Protocol for a feasibility randomized controlled trial

Bernardo Corrêa d’Almeida, Carla Cunha

published 13 May 2026

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Co-developing a survey on public understanding of sustainable clinical research: A study protocol

Dylan Keegan, Linda O’Neill, Peter Doran

published 11 May 2026

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Nasal steroids, irrigation, oral antibiotics, and subgroup targeting for effective management of acute sinusitis (NOSES): Protocol for a comparative effectiveness randomized controlled trial

Daniel Merenstein, Nawar Shara, David P. Rabago, Derjung Mimi Tarn, Bruce Barrett, Alex H. Krist, Sebastian T. Tong, Aleksandra E. Zgierska, Tina P. Tan, Keisha Herbin Smith, Gabriela Villalobos, Charles R. Fencil, Kavya K. Sanghavi, Syed Junaid Imam, Stephen Fernandez, Mihriye Mete

published 06 May 2026

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Facilitators of and barriers to participation in Long COVID research: A qualitative analysis

Lily Chu, Theodore Lucas Hollar, Nancy Klimas, Jeanne Bertolli, Ana Lia Tamariz, Aryan Lajevardi, Ilya Pavlov, Ana Palacio

published 06 May 2026

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Integration of palliative care into phase I oncology trials: A qualitative interview study with patients, informal caregivers, and healthcare providers

Frederick Daenen, Anne van Driessche, Anne-Lore Scherrens, Annelies Janssens, Sylvie Rottey, Lore Decoster, Peter A. J. Stevens, Koen Pardon, Aline De Vleminck, Kim Beernaert

published 05 May 2026

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Clinical trial participant information leaflets overstate the harms/risks of participation and understate the benefits

Rafaela Carapeto, Andrew Willis, Frances Shiely

published 05 May 2026

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