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Phase II clinical investigation

Efficacy and safety of MEK inhibitors for NF1-associated symptomatic, inoperable plexiform neurofibromas: A systematic review and meta-analysis

Sudarshawn Damodharan, James Tonsgard

Comparative study on the clinical effectiveness of low-concentration cyclosporine eye drops in patients with dry eye disease

Jae Hyun Kim, Hui Kyung Kim, [ ... ], Jong Soo Lee

Resilience factors, pain, and physical activity in adolescent chronic musculoskeletal pain: Design and protocol of a pilot phase 2 single-group, non-randomized clinical trial

Faith Logan, Madeline Marsh, [ ... ], William Black

‘Pilot RCT of a new treatment for child conduct problems that have not responded to evidence-based parent training’

Helen Sharp, Hermione Roff, [ ... ], Jonathan Hill

Protocol for the SACLA trial: Efficacy and safety of subretinal monteplase for submacular hemorrhage in a phase II single-arm multicenter decentralized clinical trial

Noriko Yoshida, Yuko Kobayakawa, [ ... ], Hiroshi Enaida

Effects of taurine supplementation on metabolic health and biological aging in healthcare workers: A protocol for a triple-blinded, Bayesian-optimized phase II randomized controlled trial

Mandy H. M. Chu, Jacky K. M. Lai, [ ... ], Kwok M. Ho

Co-developing a survey on public understanding of sustainable clinical research: A study protocol

Dylan Keegan, Linda O’Neill, Peter Doran

Nasal steroids, irrigation, oral antibiotics, and subgroup targeting for effective management of acute sinusitis (NOSES): Protocol for a comparative effectiveness randomized controlled trial

Daniel Merenstein, Nawar Shara, [ ... ], Mihriye Mete

The effects of vaginal gel from Myrtus communis on the sexual function of married women during reproductive aging: A study protocol for a randomized controlled trial

Bahareh khajehpour, Raheleh Babazadeh, [ ... ], Malihe Mahmoudinia

Adaptation and evaluation of a digital dialectical behaviour therapy for youth at clinical high risk for psychosis: A protocol for a feasibility randomized controlled trial

Thea Lynne Hedemann, Yun Lu, [ ... ], Muhammad Omair Husain

Comparing the impact of systemic pituitary adenylate-cyclase-activating polypeptide (PACAP) and calcitonin gene-related peptide (CGRP) on motion-induced nausea and balance behaviors in mice

Shafaqat M. Rahman, Abigail Dweh, Anne E. Luebke

The efficacy and safety of lignocaine-embedded dissolvable microneedle versus EMLA for topical analgesia in adults undergoing venepuncture: A single-centre, parallel-group, double-blind randomised clinical trial protocol in a tertiary care setting

Muhammad Irfan Abdul Jalal, Mun Yin Yen, [ ... ], Fook-Choe Cheah

Personal approach for cancer treatment: A meta-analysis of Phase II clinical trials

Mikhail B. Potievskiy, Elena P. Zharova, [ ... ], Peter V. Shegai

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