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Biochemistry

Repurposing the phospholipase A2 inhibitor, darapladib, to combat multidrug-resistant fungal pathogens, including Candida auris

Yehia Elgammal, Ehab A. Salama, Nour M. Alkashef, Christopher B. Lawrence, Mohamed N. Seleem

published 26 Oct 2026

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Grb2 phosphorylation antagonizes EGFR-driven ras activation by interfering with condensate assembly

Henry T. Phan, Chun-Wei Lin, Brittany L. Stinger, Joseph B. DeGrandchamp, L. J. Nugent Lew, Serena J. Huang, Jay T. Groves

published 26 Oct 2026

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The effect of STAT1 expression and the Y701 phosphorylation on primary Undifferentiated Pleomorphic Sarcoma cells

Victoria S. Coward, Nalan Gokgoz, Kim M. Tsoi, Jay S. Wunder, Irene L. Andrulis

published 26 Oct 2026

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The association between e-cigarette use and dyslipidemia: A systematic review and meta-analysis of observational studies

Humam Emad Rajha, Sara Mohsen, Hadeel Alkuwari, Janatul Naeim, Wejdan Al-Marri, Ahmad Hamdan, Tawanda Chivese, Rafif Mahmood Al Saady

published 26 Oct 2026

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Handwriting-based Alzheimer’s disease classification on the DARWIN dataset: Repeated nested validation, task-level reduction, and cross-validated explainability

Tehreem Fatima, Tahira Anwar Lashari, Momina Moetesum, Sana Anwar Lashari

published 26 Oct 2026

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Morphophysiological and biochemical responses of two grape cultivars to phosphorus deficiency and toxicity

Maryam Zaeri Behrooz, Rouhollah Karimi, Ali Khadivi, Yazgan Tunç, Lalu Prasad Yadav

published 26 Oct 2026

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PARG inhibition suppresses osteoclast differentiation through transcriptional activation of an NRF2-dependent pathway

Yuka Sasaki, Ryusuke Nakatsuka, Ryoji Taniguchi, Amane Inoue, Mitsuko Masutani, Tadashige Nozaki

published 26 Oct 2026

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Effects of egg-mass-dissolving substances on the post-embryonic development of Chrysomya megacephala (Fabricius, 1794) and Chrysomya putoria (Wiedemann, 1830) (Diptera: Calliphoridae): Implications for maggot therapy

Mariana dos Passos Nunes, João Pedro de Oliveira Lima, Jéssica da Silva Costa, Cláudia Soares Santos Lessa, Renato Geraldo da Silva Filho, Jeronimo Alencar, Valéria Magalhães Aguiar

published 26 Oct 2026

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Depressive symptoms are associated with the incidence of frailty in older adults with cardiometabolic diseases: Interaction between depression and diabetes

Fumino Kobayashi, Yoshiaki Tamura, Yuji Murao, Kenji Toyoshima, Kazuhito Oba, Remi Kodera, Ai Iizuka, Yuko Chiba, Ayumi Toba, Takumi Hirata, Yumi Shindo, Joji Ishikawa, Atsushi Araki

published 26 Oct 2026

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Evaluating associations of oxylipin metabolites and fatty acids with incident and prevalent type 2 diabetes in the Hispanic Community Health Study/Study of Latinos (HCHS/SOL)

Carolina G. Downie, Heather M. Highland, Annie Green Howard, Mona Alotaibi, Tali Elfassy, Christina Cordero, Jennifer E. Below, Mercedes Carnethon, Susan Cheng, Martha Daviglus, Olga Garcia-Bedoya, Robert Kaplan, Tasneem Khambaty, Yilun Li, Adam G. Lilly, Dan-Yu Lin, Tao Long, Frank J. Penedo, Lauren E. Petty, Bharat Thyagarajan, Hsiao-Chuan Tien, Mohit Jain, Barrett M. Welch, Kari E. North, Christy L. Avery

published 26 Oct 2026

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The mitochondrial genomes of the endemic and endangered South Philippine Hawk-eagle Nisaetus pinskeri and other Nisaetus Hawk-eagles (Aves, Accipitriformes)

Dhan Mikhail Perdon, John Michael Egana, Francis Tablizo, Renato Jacinto Mantaring, Kris Punayan, Shiela Mae Araiza, Jo-Hannah Llames, Ma. Celeste Abad, Jayson Ibañez, Cynthia P. Saloma

published 26 Oct 2026

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Integrative in vitro, in vivo, and in silico investigation with mineral profiling of Combretum indicum: A multi-target therapeutic candidate exhibiting antioxidant, thrombolytic, anti-inflammatory, anti-arthritic, analgesic, cytotoxic, and anthelmintic activities

Zobayed Islam, Hridoy Chowdhury, Sujan Kanti Das, Ahnuf Zaman Tomal, Anik Das, S. M. Naim Uddin

published 26 Oct 2026

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Insights on the effect of extracellular acidification on an HCN channel: A molecular dynamics study

Somayeh Asgharpour, Michalis Lazaratos, Marc Spehr, Paolo Carloni

published 26 Oct 2026

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