February 2017

Adult male Trichuris muris parasite shown partly removed from its epithelial niche within the gut. Individual cells of the stichosome are clearly visible within the long thin whip-like anterior which is normally embedded within the gut epithelial cells of the host. The image was generated by X-ray micro-computed tomography after staining with osmium tetroxide. Partridge et al.

Image Credit: Kathryn Else / The image was generated with assistance provided by the Manchester X-ray Imaging Facility (Julia Behnsen), which was funded in part by the EPSRC (grants EP/F007906/1, EP/F001452/1 and EP/I02249X/1), and the EM facility within the Faculty of Biology, Medicine and Health, University of Manchester.

Editorial

Global urbanization and the neglected tropical diseases

Peter J. Hotez

PLOS Neglected Tropical Diseases: published February 23, 2017 | https://doi.org/10.1371/journal.pntd.0005308

Viewpoints

Congenital Toxoplasmosis in France and the United States: One Parasite, Two Diverging Approaches

Francois Peyron, Rima Mc Leod, Daniel Ajzenberg, Despina Contopoulos-Ioannidis, François Kieffer, Laurent Mandelbrot, L. David Sibley, Hervé Pelloux, Isabelle Villena, Martine Wallon, Jose G. Montoya

PLOS Neglected Tropical Diseases: published February 16, 2017 | https://doi.org/10.1371/journal.pntd.0005222

Policy Platform

Update on Zika Diagnostic Tests and WHO’s Related Activities

Arlene Chua, Irena Prat, Claudius Micha Nuebling, David Wood, Francis Moussy

PLOS Neglected Tropical Diseases: published February 2, 2017 | https://doi.org/10.1371/journal.pntd.0005269

From Innovation to Application

Making Transmission Models Accessible to End-Users: The Example of TRANSFIL

Michael A. Irvine, T. Deirdre Hollingsworth

PLOS Neglected Tropical Diseases: published February 2, 2017 | https://doi.org/10.1371/journal.pntd.0005206

Symposiums

Product development programs for neglected tropical diseases: A crucial role for expert meetings

Leonie Hussaarts, Kim van der Weijde, Pierre Dome, Elly Kourany-Lefoll, Jutta Reinhard-Rupp, Remco de Vrueh, on behalf of the Pediatric Praziquantel Consortium

PLOS Neglected Tropical Diseases: published February 23, 2017 | https://doi.org/10.1371/journal.pntd.0005183

Visceral leishmaniasis during pregnancy: A rare case report from Greece

Periklis Panagopoulos, Vasileios Mitsopoulos, Antonios Papadopoulos, Spyridoula Theodorou, Chrysoula Christodoulaki, Kyriakos Aloupogiannis, Nikolaos Papantoniou

PLOS Neglected Tropical Diseases: published February 16, 2017 | https://doi.org/10.1371/journal.pntd.0005134

Reviews

Galectin-3, histone deacetylases, and Hedgehog signaling: Possible convergent targets in schistosomiasis-induced liver fibrosis

Felipe Leite de Oliveira, Katia Carneiro, José Marques Brito, Mariana Cabanel, Jonathas Xavier Pereira, Ligia de Almeida Paiva, Wingkin Syn, Neil C. Henderson, Marcia Cury El-Cheikh

PLOS Neglected Tropical Diseases: published February 23, 2017 | https://doi.org/10.1371/journal.pntd.0005137

Nakalanga Syndrome: Clinical Characteristics, Potential Causes, and Its Relationship with Recently Described Nodding Syndrome

Kathrin Föger, Gina Gora-Stahlberg, James Sejvar, Emilio Ovuga, Louise Jilek-Aall, Erich Schmutzhard, Christoph Kaiser, Andrea S. Winkler

PLOS Neglected Tropical Diseases: published February 9, 2017 | https://doi.org/10.1371/journal.pntd.0005201

Environmental and Social Change Drive the Explosive Emergence of Zika Virus in the Americas

Sofia Ali, Olivia Gugliemini, Serena Harber, Alexandra Harrison, Lauren Houle, Javarcia Ivory, Sierra Kersten, Rebia Khan, Jenny Kim, Chris LeBoa, Emery Nez-Whitfield, Jamieson O’Marr, Emma Rothenberg, R. Max Segnitz, Stephanie Sila, Anna Verwillow, Miranda Vogt, Adrienne Yang, Erin A. Mordecai

PLOS Neglected Tropical Diseases: published February 9, 2017 | https://doi.org/10.1371/journal.pntd.0005135

Research Articles

Comparative analysis of gut microbiota of mosquito communities in central Illinois

Ephantus J. Muturi, Jose L. Ramirez, Alejandro P. Rooney, Chang-Hyun Kim

PLOS Neglected Tropical Diseases: published February 28, 2017 | https://doi.org/10.1371/journal.pntd.0005377

Assessing and managing wounds of Buruli ulcer patients at the primary and secondary health care levels in Ghana

Naa Okaikor Addison, Stefanie Pfau, Eric Koka, Samuel Yaw Aboagye, Grace Kpeli, Gerd Pluschke, Dorothy Yeboah-Manu, Thomas Junghanss

PLOS Neglected Tropical Diseases: published February 28, 2017 | https://doi.org/10.1371/journal.pntd.0005331

EGF-mediated EGFR/ERK signaling pathway promotes germinative cell proliferation in Echinococcus multilocularis that contributes to larval growth and development

Zhe Cheng, Fan Liu, Xiu Li, Mengya Dai, Jianjian Wu, Xinrui Guo, Huimin Tian, Zhijie Heng, Ying Lu, Xiaoli Chai, Yanhai Wang

PLOS Neglected Tropical Diseases: published February 27, 2017 | https://doi.org/10.1371/journal.pntd.0005418

Analysis of Mycobacterium ulcerans-specific T-cell cytokines for diagnosis of Buruli ulcer disease and as potential indicator for disease progression

Norman Nausch, Daniel Antwi-Berko, Yusif Mubarik, Kabiru Mohammed Abass, Wellington Owusu, Ellis Owusu-Dabo, Linda Batsa Debrah, Alexander Yaw Debrah, Marc Jacobsen, Richard O. Phillips

PLOS Neglected Tropical Diseases: published February 27, 2017 | https://doi.org/10.1371/journal.pntd.0005415

Seeking the environmental source of Leptospirosis reveals durable bacterial viability in river soils

Roman Thibeaux, Sophie Geroult, Claire Benezech, Stéphane Chabaud, Marie-Estelle Soupé-Gilbert, Dominique Girault, Emilie Bierque, Cyrille Goarant

PLOS Neglected Tropical Diseases: published February 27, 2017 | https://doi.org/10.1371/journal.pntd.0005414

Cytokines and microbicidal molecules regulated by IL-32 in THP-1-derived human macrophages infected with New World Leishmania species

Jéssica Cristina dos Santos, Bas Heinhuis, Rodrigo Saar Gomes, Michelle S. M. A. Damen, Fernando Real, Renato A. Mortara, Samuel T. Keating, Charles A. Dinarello, Leo A. B. Joosten, Fátima Ribeiro-Dias

PLOS Neglected Tropical Diseases: published February 27, 2017 | https://doi.org/10.1371/journal.pntd.0005413

Association of a new FCN3 haplotype with high ficolin-3 levels in leprosy

Fabiana Antunes Andrade, Marcia Holsbach Beltrame, Valéria Bumiller Bini, Letícia Boslooper Gonçalves, Angelica Beate Winter Boldt, Iara Jose de Messias-Reason

PLOS Neglected Tropical Diseases: published February 27, 2017 | https://doi.org/10.1371/journal.pntd.0005409

Sand fly population dynamics and cutaneous leishmaniasis among soldiers in an Atlantic forest remnant in northeastern Brazil

Filipe Dantas-Torres, Kamila Gaudêncio da Silva Sales, Débora Elienai de Oliveira Miranda, Fernando José da Silva, Luciana Aguiar Figueredo, Fábio Lopes de Melo, Maria Edileuza Felinto de Brito, Maria Sandra Andrade, Sinval Pinto Brandão-Filho

PLOS Neglected Tropical Diseases: published February 27, 2017 | https://doi.org/10.1371/journal.pntd.0005406

Use of eschar swabbing for the molecular diagnosis and genotyping of Orientia tsutsugamushi causing scrub typhus in Quang Nam province, Vietnam

Nhiem Le Viet, Maureen Laroche, Hoa L. Thi Pham, Nho L. Viet, Oleg Mediannikov, Didier Raoult, Philippe Parola

PLOS Neglected Tropical Diseases: published February 27, 2017 | https://doi.org/10.1371/journal.pntd.0005397

Spatial clustering and local risk of leprosy in São Paulo, Brazil

Antônio Carlos Vieira Ramos, Mellina Yamamura, Luiz Henrique Arroyo, Marcela Paschoal Popolin, Francisco Chiaravalloti Neto, Pedro Fredemir Palha, Severina Alice da Costa Uchoa, Flávia Meneguetti Pieri, Ione Carvalho Pinto, Regina Célia Fiorati, Ana Angélica Rêgo de Queiroz, Aylana de Souza Belchior, Danielle Talita dos Santos, Maria Concebida da Cunha Garcia, Juliane de Almeida Crispim, Luana Seles Alves, Thaís Zamboni Berra, Ricardo Alexandre Arcêncio

PLOS Neglected Tropical Diseases: published February 27, 2017 | https://doi.org/10.1371/journal.pntd.0005381

The burden of typhoid fever in low- and middle-income countries: A meta-regression approach

Marina Antillón, Joshua L. Warren, Forrest W. Crawford, Daniel M. Weinberger, Esra Kürüm, Gi Deok Pak, Florian Marks, Virginia E. Pitzer

PLOS Neglected Tropical Diseases: published February 27, 2017 | https://doi.org/10.1371/journal.pntd.0005376

Endomyocardial involvement in asymptomatic sub-Saharan immigrants with helminth-related eosinophilia

Cristina Carranza-Rodríguez, Daniel San-Román-Sánchez, Héctor Marrero-Santiago, Michele Hernández-Cabrera, Carlos Gil-Guillén, Elena Pisos-Álamo, Nieves Jaén-Sánchez, José-Luis Pérez-Arellano

PLOS Neglected Tropical Diseases: published February 24, 2017 | https://doi.org/10.1371/journal.pntd.0005403

Experimental infection and transmission of Leishmania by Lutzomyia cruzi (Diptera: Psychodidae): Aspects of the ecology of parasite-vector interactions

Everton Falcão de Oliveira, Elisa Teruya Oshiro, Wagner de Souza Fernandes, Paula Guerra Murat, Márcio José de Medeiros, Alda Izabel Souza, Alessandra Gutierrez de Oliveira, Eunice Aparecida Bianchi Galati

PLOS Neglected Tropical Diseases: published February 24, 2017 | https://doi.org/10.1371/journal.pntd.0005401

Immunization with Tc52 or its amino terminal domain adjuvanted with c-di-AMP induces Th17+Th1 specific immune responses and confers protection against Trypanosoma cruzi

Marina N. Matos, Silvia I. Cazorla, Kai Schulze, Thomas Ebensen, Carlos A. Guzmán, Emilio L. Malchiodi

PLOS Neglected Tropical Diseases: published February 24, 2017 | https://doi.org/10.1371/journal.pntd.0005300

Favipiravir pharmacokinetics in Ebola-Infected patients of the JIKI trial reveals concentrations lower than targeted

Thi Huyen Tram Nguyen, Jérémie Guedj, Xavier Anglaret, Cédric Laouénan, Vincent Madelain, Anne-Marie Taburet, Sylvain Baize, Daouda Sissoko, Boris Pastorino, Anne Rodallec, Géraldine Piorkowski, Sara Carazo, Mamoudou N. Conde, Jean-Luc Gala, Joseph Akoi Bore, Caroline Carbonnelle, Frédéric Jacquot, Hervé Raoul, Denis Malvy, Xavier de Lamballerie, France Mentré, on behalf of the JIKI study group

PLOS Neglected Tropical Diseases: published February 23, 2017 | https://doi.org/10.1371/journal.pntd.0005389

Unexpectedly high leprosy seroprevalence detected using a random surveillance strategy in midwestern Brazil: A comparison of ELISA and a rapid diagnostic test

Marco Andrey C. Frade, Natália A. de Paula, Ciro M. Gomes, Sebastian Vernal, Fred Bernardes Filho, Helena B. Lugão, Marilda M. M. de Abreu, Patrícia Botini, Malcolm S. Duthie, John S. Spencer, Rosa Castália F. R. Soares, Norma T. Foss

PLOS Neglected Tropical Diseases: published February 23, 2017 | https://doi.org/10.1371/journal.pntd.0005375

Hydrocephalus and arthrogryposis in an immunocompetent mouse model of ZIKA teratogeny: A developmental study

Jose Xavier-Neto, Murilo Carvalho, Bruno dos Santos Pascoalino, Alisson Campos Cardoso, Ângela Maria Sousa Costa, Ana Helena Macedo Pereira, Luana Nunes Santos, Ângela Saito, Rafael Elias Marques, Juliana Helena Costa Smetana, Silvio Roberto Consonni, Carla Bandeira, Vivian Vasconcelos Costa, Marcio Chaim Bajgelman, Paulo Sérgio Lopes de Oliveira, Marli Tenorio Cordeiro, Laura Helena Vega Gonzales Gil, Bianca Alves Pauletti, Daniela Campos Granato, Adriana Franco Paes Leme, Lucio Freitas-Junior, Carolina Borsoi Moraes Holanda de Freitas, Mauro Martins Teixeira, Estela Bevilacqua, Kleber Franchini

PLOS Neglected Tropical Diseases: published February 23, 2017 | https://doi.org/10.1371/journal.pntd.0005363

Predicting Ebola infection: A malaria-sensitive triage score for Ebola virus disease

Mary-Anne Hartley, Alyssa Young, Anh-Minh Tran, Harry Henry Okoni-Williams, Mohamed Suma, Brooke Mancuso, Ahmed Al-Dikhari, Mohamed Faouzi

PLOS Neglected Tropical Diseases: published February 23, 2017 | https://doi.org/10.1371/journal.pntd.0005356

Intensive trapping of blood-fed Anopheles darlingi in Amazonian Peru reveals unexpectedly high proportions of avian blood-meals

Marta Moreno, Marlon P. Saavedra, Sara A. Bickersmith, Catharine Prussing, Adrian Michalski, Carlos Tong Rios, Joseph M. Vinetz, Jan E. Conn

PLOS Neglected Tropical Diseases: published February 23, 2017 | https://doi.org/10.1371/journal.pntd.0005337

Cynomolgus macaques naturally infected with Trypanosoma cruzi-I exhibit an overall mixed pro-inflammatory/modulated cytokine signature characteristic of human Chagas disease

Danielle Marquete Vitelli-Avelar, Renato Sathler-Avelar, Armanda Moreira Mattoso-Barbosa, Nicolas Gouin, Marcelo Perdigão-de-Oliveira, Leydiane Valério-dos-Reis, Ronaldo Peres Costa, Silvana Maria Elói-Santos, Matheus de Souza Gomes, Laurence Rodrigues do Amaral, Andréa Teixeira-Carvalho, Olindo Assis Martins-Filho, Edward J. Dick Jr., Gene B. Hubbard, Jane F. VandeBerg, John L. VandeBerg

PLOS Neglected Tropical Diseases: published February 22, 2017 | https://doi.org/10.1371/journal.pntd.0005233

Cytotoxic effector functions of T cells are not required for protective immunity against fatal Rickettsia typhi infection in a murine model of infection: Role of T_H1 and T_H17 cytokines in protection and pathology

Kristin Moderzynski, Liza Heine, Jessica Rauch, Stefanie Papp, Svenja Kuehl, Ulricke Richardt, Bernhard Fleischer, Anke Osterloh

PLOS Neglected Tropical Diseases: published February 21, 2017 | https://doi.org/10.1371/journal.pntd.0005404

Ultrasonographic evaluation of urinary tract morbidity in school-aged and preschool-aged children infected with Schistosoma haematobium and its evolution after praziquantel treatment: A randomized controlled trial

Beatrice Barda, Jean T. Coulibaly, Christoph Hatz, Jennifer Keiser

PLOS Neglected Tropical Diseases: published February 21, 2017 | https://doi.org/10.1371/journal.pntd.0005400

Leprosy reactions: The predictive value of Mycobacterium leprae-specific serology evaluated in a Brazilian cohort of leprosy patients (U-MDT/CT-BR)

Emerith Mayra Hungria, Samira Bührer-Sékula, Regiane Morillas de Oliveira, Lúcio Cartaxo Aderaldo, Araci de Andrade Pontes, Rossilene Cruz, Heitor de Sá Gonçalves, Maria Lúcia Fernandes Penna, Gerson Oliveira Penna, Mariane Martins de Araújo Stefani

PLOS Neglected Tropical Diseases: published February 21, 2017 | https://doi.org/10.1371/journal.pntd.0005396

Dengue virus antibody database: Systematically linking serotype-specificity with epitope mapping in dengue virus

Sidhartha Chaudhury, Gregory D. Gromowski, Daniel R. Ripoll, Ilja V. Khavrutskii, Valmik Desai, Anders Wallqvist

PLOS Neglected Tropical Diseases: published February 21, 2017 | https://doi.org/10.1371/journal.pntd.0005395

Anti-trypanosomal activity of non-peptidic nitrile-based cysteine protease inhibitors

Antonio C. B. Burtoloso, Sérgio de Albuquerque, Mark Furber, Juliana C. Gomes, Cristiana Gonçalez, Peter W. Kenny, Andrei Leitão, Carlos A. Montanari, José Carlos Quilles Júnior, Jean F. R. Ribeiro, Josmar R. Rocha

PLOS Neglected Tropical Diseases: published February 21, 2017 | https://doi.org/10.1371/journal.pntd.0005343

Unusual pattern of chikungunya virus epidemic in the Americas, the Panamanian experience

Jean-Paul Carrera, Yamilka Díaz, Bernardino Denis, Itza Barahona de Mosca, Dennys Rodriguez, Israel Cedeño, Dimelza Arauz, Publio González, Lizbeth Cerezo, Lourdes Moreno, Lourdes García, Lisseth E. Sáenz, María Aneth Atencio, Eddy Rojas-Fermin, Fernando Vizcaino, Nicolas Perez, Brechla Moreno, Sandra López-Vergès, Anayansi Valderrama, Blas Armién

PLOS Neglected Tropical Diseases: published February 21, 2017 | https://doi.org/10.1371/journal.pntd.0005338

Decline in infection-related morbidities following drug-mediated reductions in the intensity of Schistosoma infection: A systematic review and meta-analysis

Gisele Andrade, David J. Bertsch, Andrea Gazzinelli, Charles H. King

PLOS Neglected Tropical Diseases: published February 17, 2017 | https://doi.org/10.1371/journal.pntd.0005372

Modelling the risk of Taenia solium exposure from pork produced in western Kenya

Lian F. Thomas, William A. de Glanville, Elizabeth A. J. Cook, Barend M. De C. Bronsvoort, Ian Handel, Claire N. Wamae, Samuel Kariuki, Eric M. Fèvre

PLOS Neglected Tropical Diseases: published February 17, 2017 | https://doi.org/10.1371/journal.pntd.0005371

Distribution and abundance of key vectors of Rift Valley fever and other arboviruses in two ecologically distinct counties in Kenya

Rosemary Sang, Samwel Arum, Edith Chepkorir, Gladys Mosomtai, Caroline Tigoi, Faith Sigei, Olivia Wesula Lwande, Tobias Landmann, Hippolyte Affognon, Clas Ahlm, Magnus Evander

PLOS Neglected Tropical Diseases: published February 17, 2017 | https://doi.org/10.1371/journal.pntd.0005341

Partnering for impact: Integrated transmission assessment surveys for lymphatic filariasis, soil transmitted helminths and malaria in Haiti

Alaine Kathryn Knipes, Jean Frantz Lemoine, Franck Monestime, Carl R. Fayette, Abdel N. Direny, Luccene Desir, Valery E. Beau de Rochars, Thomas G. Streit, Kristen Renneker, Brian K. Chu, Michelle A. Chang, Kimberly E. Mace, Kimberly Y. Won, Patrick J. Lammie

PLOS Neglected Tropical Diseases: published February 16, 2017 | https://doi.org/10.1371/journal.pntd.0005387

The One Health approach to identify knowledge, attitudes and practices that affect community involvement in the control of Rift Valley fever outbreaks

Osama Ahmed Hassan, Hippolyte Affognon, Joacim Rocklöv, Peter Mburu, Rosemary Sang, Clas Ahlm, Magnus Evander

PLOS Neglected Tropical Diseases: published February 16, 2017 | https://doi.org/10.1371/journal.pntd.0005383

Comparative and functional triatomine genomics reveals reductions and expansions in insecticide resistance-related gene families

Lucila Traverso, Andrés Lavore, Ivana Sierra, Victorio Palacio, Jesús Martinez-Barnetche, José Manuel Latorre-Estivalis, Gaston Mougabure-Cueto, Flavio Francini, Marcelo G. Lorenzo, Mario Henry Rodríguez, Sheila Ons, Rolando V. Rivera-Pomar

PLOS Neglected Tropical Diseases: published February 15, 2017 | https://doi.org/10.1371/journal.pntd.0005313

Species dependent impact of helminth-derived antigens on human macrophages infected with Mycobacterium tuberculosis: Direct effect on the innate anti-mycobacterial response

Naomi Aira, Anna-Maria Andersson, Susmita K. Singh, Derek M. McKay, Robert Blomgran

PLOS Neglected Tropical Diseases: published February 13, 2017 | https://doi.org/10.1371/journal.pntd.0005390

Comparative genome analysis of VSP-II and SNPs reveals heterogenic variation in contemporary strains of Vibrio cholerae O1 isolated from cholera patients in Kolkata, India

Daisuke Imamura, Masatomo Morita, Tsuyoshi Sekizuka, Tamaki Mizuno, Taichiro Takemura, Tetsu Yamashiro, Goutam Chowdhury, Gururaja P. Pazhani, Asish K. Mukhopadhyay, Thandavarayan Ramamurthy, Shin-ichi Miyoshi, Makoto Kuroda, Sumio Shinoda, Makoto Ohnishi

PLOS Neglected Tropical Diseases: published February 13, 2017 | https://doi.org/10.1371/journal.pntd.0005386

Advances in neglected tropical disease vaccines: Developing relative potency and functional assays for the Na-GST-1/Alhydrogel hookworm vaccine

Jill B. Brelsford, Jordan L. Plieskatt, Anna Yakovleva, Amar Jariwala, Brian P. Keegan, Jin Peng, Pengjun Xia, Guangzhao Li, Doreen Campbell, Maria Victoria Periago, Rodrigo Correa-Oliveira, Maria Elena Bottazzi, Peter J. Hotez, David Diemert, Jeffrey M. Bethony

PLOS Neglected Tropical Diseases: published February 13, 2017 | https://doi.org/10.1371/journal.pntd.0005385

Multibacillary leprosy by population groups in Brazil: Lessons from an observational study

Mauricio Lisboa Nobre, Ximena Illarramendi, Kathryn Margaret Dupnik, Mariana de Andrea Hacker, José Augusto da Costa Nery, Selma Maria Bezerra Jerônimo, Euzenir Nunes Sarno

PLOS Neglected Tropical Diseases: published February 13, 2017 | https://doi.org/10.1371/journal.pntd.0005364

Improving access to Chagas disease diagnosis and etiologic treatment in remote rural communities of the Argentine Chaco through strengthened primary health care and broad social participation

Paula Sartor, Ivana Colaianni, M. Victoria Cardinal, Jacqueline Bua, Héctor Freilij, Ricardo E. Gürtler

PLOS Neglected Tropical Diseases: published February 13, 2017 | https://doi.org/10.1371/journal.pntd.0005336

Review of 21 cases of mycetoma from 1991 to 2014 in Rio de Janeiro, Brazil

Felipe Maurício Soeiro Sampaio, Bodo Wanke, Dayvison Francis Saraiva Freitas, Janice Mery Chicarino de Oliveira Coelho, Maria Clara Gutierrez Galhardo, Marcelo Rosandiski Lyra, Maria Cristina da Silva Lourenço, Rodrigo de Almeida Paes, Antonio Carlos Francesconi do Valle

PLOS Neglected Tropical Diseases: published February 13, 2017 | https://doi.org/10.1371/journal.pntd.0005301

Holding back the tiger: Successful control program protects Australia from Aedes albopictus expansion

Mutizwa Odwell Muzari, Gregor Devine, Joseph Davis, Bruce Crunkhorn, Andrew van den Hurk, Peter Whelan, Richard Russell, James Walker, Peter Horne, Gerhard Ehlers, Scott Ritchie

PLOS Neglected Tropical Diseases: published February 13, 2017 | https://doi.org/10.1371/journal.pntd.0005286

Mosquito cell-derived West Nile virus replicon particles mimic arbovirus inoculum and have reduced spread in mice

Brendan T. Boylan, Fernando R. Moreira, Tim W. Carlson, Kristen A. Bernard

PLOS Neglected Tropical Diseases: published February 10, 2017 | https://doi.org/10.1371/journal.pntd.0005394

Asymptomatic leishmaniasis in kala-azar endemic areas of Malda district, West Bengal, India

Pabitra Saha, Swagata Ganguly, Moytrey Chatterjee, Soumendu Bikash Das, Pratip K. Kundu, Subhasish K. Guha, Tamal K. Ghosh, Dilip K. Bera, Nandita Basu, Ardhendu K. Maji

PLOS Neglected Tropical Diseases: published February 10, 2017 | https://doi.org/10.1371/journal.pntd.0005391

Podoconiosis, trachomatous trichiasis and cataract in northern Ethiopia: A comparative cross sectional study

Helen Burn, Sintayehu Aweke, Tariku Wondie, Esmael Habtamu, Kebede Deribe, Saul Rajak, Stephen Bremner, Gail Davey

PLOS Neglected Tropical Diseases: published February 10, 2017 | https://doi.org/10.1371/journal.pntd.0005388

Detection of the mosquito-borne flaviviruses, West Nile, Dengue, Saint Louis Encephalitis, Ilheus, Bussuquara, and Yellow Fever in free-ranging black howlers (Alouatta caraya) of Northeastern Argentina

María A. Morales, Cintia M. Fabbri, Gabriel E. Zunino, Martín M. Kowalewski, Victoria C. Luppo, Delia A. Enría, Silvana C. Levis, Gladys E. Calderón

PLOS Neglected Tropical Diseases: published February 10, 2017 | https://doi.org/10.1371/journal.pntd.0005351

Killing of diverse eye pathogens (Acanthamoeba spp., Fusarium solani, and Chlamydia trachomatis) with alcohols

Yousuf Aqeel, Raquel Rodriguez, Aparajita Chatterjee, Robin R. Ingalls, John Samuelson

PLOS Neglected Tropical Diseases: published February 9, 2017 | https://doi.org/10.1371/journal.pntd.0005382

Improving our forecasts for trachoma elimination: What else do we need to know?

Amy Pinsent, Manoj Gambhir

PLOS Neglected Tropical Diseases: published February 9, 2017 | https://doi.org/10.1371/journal.pntd.0005378

Metformin exhibits preventive and therapeutic efficacy against experimental cystic echinococcosis

Julia A. Loos, Valeria A. Dávila, Christian R. Rodrígues, Romina Petrigh, Jorge A. Zoppi, Fernando A. Crocenzi, Andrea C. Cumino

PLOS Neglected Tropical Diseases: published February 9, 2017 | https://doi.org/10.1371/journal.pntd.0005370

Dihydrobenz[e][1,4]oxazepin-2(3H)-ones, a new anthelmintic chemotype immobilising whipworm and reducing infectivity in vivo

Frederick A. Partridge, Emma A. Murphy, Nicky J. Willis, Carole J. R. Bataille, Ruth Forman, Narinder Heyer-Chauhan, Bruno Marinič, Daniel J. C. Sowood, Graham M. Wynne, Kathryn J. Else, Angela J. Russell, David B. Sattelle

PLOS Neglected Tropical Diseases: published February 9, 2017 | https://doi.org/10.1371/journal.pntd.0005359

Modeling the Potential for Vaccination to Diminish the Burden of Invasive Non-typhoidal Salmonella Disease in Young Children in Mali, West Africa

Kristin Bornstein, Laura Hungerford, David Hartley, John D. Sorkin, Milagritos D. Tapia, Samba O. Sow, Uma Onwuchekwa, Raphael Simon, Sharon M. Tennant, Myron M. Levine

PLOS Neglected Tropical Diseases: published February 9, 2017 | https://doi.org/10.1371/journal.pntd.0005283

Investigation on predominant Leptospira serovars and its distribution in humans and livestock in Thailand, 2010-2015

Sudarat Chadsuthi, Dominique J. Bicout, Anuwat Wiratsudakul, Duangjai Suwancharoen, Wimol Petkanchanapong, Charin Modchang, Wannapong Triampo, Parntep Ratanakorn, Karine Chalvet-Monfray

PLOS Neglected Tropical Diseases: published February 9, 2017 | https://doi.org/10.1371/journal.pntd.0005228

Trypanosoma cruzi High Mobility Group B (TcHMGB) can act as an inflammatory mediator on mammalian cells

Pamela Cribb, Virginia Perdomo, Victoria L. Alonso, Romina Manarin, Jorge Barrios-Payán, Brenda Marquina-Castillo, Luis Tavernelli, Rogelio Hernández-Pando

PLOS Neglected Tropical Diseases: published February 8, 2017 | https://doi.org/10.1371/journal.pntd.0005350

Prevalence and clinical relevance of helminth co-infections among tuberculosis patients in urban Tanzania

Francis Mhimbira, Jerry Hella, Khadija Said, Lujeko Kamwela, Mohamed Sasamalo, Thomas Maroa, Magreth Chiryamkubi, Grace Mhalu, Christian Schindler, Klaus Reither, Stefanie Knopp, Jürg Utzinger, Sébastien Gagneux, Lukas Fenner

PLOS Neglected Tropical Diseases: published February 8, 2017 | https://doi.org/10.1371/journal.pntd.0005342

The impact of prenatal exposure to parasitic infections and to anthelminthic treatment on antibody responses to routine immunisations given in infancy: Secondary analysis of a randomised controlled trial

Stephen Nash, Alexander J. Mentzer, Swaib A. Lule, Dennison Kizito, Gaby Smits, Fiona R. M. van der Klis, Alison M. Elliott

PLOS Neglected Tropical Diseases: published February 8, 2017 | https://doi.org/10.1371/journal.pntd.0005213

Risk analysis and prediction of visceral leishmaniasis dispersion in São Paulo State, Brazil

Anaiá da Paixão Sevá, Liang Mao, Fredy Galvis-Ovallos, Joanna Marie Tucker Lima, Denis Valle

PLOS Neglected Tropical Diseases: published February 6, 2017 | https://doi.org/10.1371/journal.pntd.0005353

A high-throughput phenotypic screen identifies clofazimine as a potential treatment for cryptosporidiosis

Melissa S. Love, Federico C. Beasley, Rajiv S. Jumani, Timothy M. Wright, Arnab K. Chatterjee, Christopher D. Huston, Peter G. Schultz, Case W. McNamara

PLOS Neglected Tropical Diseases: published February 3, 2017 | https://doi.org/10.1371/journal.pntd.0005373

TrypsNetDB: An integrated framework for the functional characterization of trypanosomatid proteins

Vahid H. Gazestani, Chun Wai Yip, Najmeh Nikpour, Natasha Berghuis, Reza Salavati

PLOS Neglected Tropical Diseases: published February 3, 2017 | https://doi.org/10.1371/journal.pntd.0005368

Schistosome infectivity in the snail, Biomphalaria glabrata, is partially dependent on the expression of Grctm6, a Guadeloupe Resistance Complex protein.

Euan R. O. Allan, Jacob A. Tennessen, Stephanie R. Bollmann, Patrick C. Hanington, Christopher J. Bayne, Michael S. Blouin

PLOS Neglected Tropical Diseases: published February 3, 2017 | https://doi.org/10.1371/journal.pntd.0005362

Recombinant snakebite antivenoms: A cost-competitive solution to a neglected tropical disease?

Andreas H. Laustsen, Kristoffer H. Johansen, Mikael Engmark, Mikael R. Andersen

PLOS Neglected Tropical Diseases: published February 3, 2017 | https://doi.org/10.1371/journal.pntd.0005361

DNA multigene characterization of Fasciola hepatica and Lymnaea neotropica and its fascioliasis transmission capacity in Uruguay, with historical correlation, human report review and infection risk analysis

María Dolores Bargues, Valeria Gayo, Jaime Sanchis, Patricio Artigas, Messaoud Khoubbane, Soledad Birriel, Santiago Mas-Coma

PLOS Neglected Tropical Diseases: published February 3, 2017 | https://doi.org/10.1371/journal.pntd.0005352

Plasmodium vivax Cell Traversal Protein for Ookinetes and Sporozoites (PvCelTOS) gene sequence and potential epitopes are highly conserved among isolates from different regions of Brazilian Amazon

Lana Bitencourt Chaves, Daiana de Souza Perce-da-Silva, Rodrigo Nunes Rodrigues-da-Silva, João Hermínio Martins da Silva, Gustavo Capatti Cassiano, Ricardo Luiz Dantas Machado, Lilian Rose Pratt-Riccio, Dalma Maria Banic, Josué da Costa Lima-Junior

PLOS Neglected Tropical Diseases: published February 3, 2017 | https://doi.org/10.1371/journal.pntd.0005344

Specific anti-glycan antibodies are sustained during and after parasite clearance in Schistosoma japonicum-infected rhesus macaques

Y. Y. Michelle Yang, Xiao Hong Li, Katarzyna Brzezicka, Niels-Christian Reichardt, R. Alan Wilson, Angela van Diepen, Cornelis H. Hokke

PLOS Neglected Tropical Diseases: published February 2, 2017 | https://doi.org/10.1371/journal.pntd.0005339

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Adult male whipworm (Trichuris muris) partially embedded within its epithelial niche.

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**Adult male whipworm (Trichuris muris) partially embedded within its epithelial niche.**