November 2016

We show that the essential protein translation machinery enzyme called lysyl tRNA synthetase (KRS) from different helminths can be inhibited by the same drug cladosporin. This active site binding inhibitor disables with equal potency both the African eye worm Loa loa's KRS and the snail fever causative agent S. mansoni's KRS. The structural and biochemical data suggest that derivatives of cladosporin may be promising new chemical series that can be rationally developed as new drugs against several neglected tropical diseases that are caused by eukaryotic parasites. Sharma et al.

Image Credit: J. Chhibber and Amit Sharma

Editorial

Clinical Research on Neglected Tropical Diseases: Challenges and Solutions

Marleen Boelaert, The NIDIAG Consortium

PLOS Neglected Tropical Diseases: published November 3, 2016 | https://doi.org/10.1371/journal.pntd.0004853

Viewpoints

Clinical Research in Neglected Tropical Diseases: The Challenge of Implementing Good Clinical (Laboratory) Practices

Raffaella Ravinetto, Emilie Alirol, Yodi Mahendradhata, Suman Rijal, Pascal Lutumba, Moussa Sacko, Sayda El-Safi, Kruy Lim, Harry van Loen, Jan Jacobs, Rosanna W. Peeling, Francois Chappuis, Marleen Boelaert

PLOS Neglected Tropical Diseases: published November 3, 2016 | https://doi.org/10.1371/journal.pntd.0004654

Rapid Diagnostic Tests for Neglected Infectious Diseases: Case Study Highlights Need for Customer Awareness and Postmarket Surveillance

Barbara Barbé, Kristien Verdonck, Sayda El-Safi, Basudha Khanal, Syna Teav, Jean-Roger Lilo Kalo, Raffaella Ravinetto, François Chappuis, Marleen Boelaert, Jan Jacobs

PLOS Neglected Tropical Diseases: published November 3, 2016 | https://doi.org/10.1371/journal.pntd.0004655

The Challenges of Conducting Clinical Research on Neglected Tropical Diseases in Remote Endemic Areas in Sudan

Sayda El-Safi, François Chappuis, Marleen Boelaert

PLOS Neglected Tropical Diseases: published November 3, 2016 | https://doi.org/10.1371/journal.pntd.0004736

Zika Virus May Affect the Universal Two-Child Policy: A New Challenge for China

Pengcheng Zhou, Juan Wang, Yixiang Zheng, Rongrong Zhou, Xue-Gong Fan

PLOS Neglected Tropical Diseases: published November 10, 2016 | https://doi.org/10.1371/journal.pntd.0004984

Novel Financing Model for Neglected Tropical Diseases: Development Impact Bonds Applied to Sleeping Sickness and Rabies Control

Susan Christina Welburn, Kevin Louis Bardosh, Paul Gerard Coleman

PLOS Neglected Tropical Diseases: published November 17, 2016 | https://doi.org/10.1371/journal.pntd.0005000

Historical Profiles and Perspectives

Chikungunya in Mozambique: A Forgotten History

Eduardo S. Gudo, James F. P. Black, Julie L. Cliff

PLOS Neglected Tropical Diseases: published November 17, 2016 | https://doi.org/10.1371/journal.pntd.0005001

Symposiums

Diagnosis of Persistent Fever in the Tropics: Set of Standard Operating Procedures Used in the NIDIAG Febrile Syndrome Study

Emilie Alirol, Ninon Seiko Horie, Barbara Barbé, Veerle Lejon, Kristien Verdonck, Philippe Gillet, Jan Jacobs, Philippe Büscher, Basudha Kanal, Narayan Raj Bhattarai, Sayda El Safi, Thong Phe, Kruy Lim, Long Leng, Pascal Lutumba, Deby Mukendi, Emmanuel Bottieau, Marleen Boelaert, Suman Rijal, François Chappuis

PLOS Neglected Tropical Diseases: published November 3, 2016 | https://doi.org/10.1371/journal.pntd.0004749

Experiences and Lessons from a Multicountry NIDIAG Study on Persistent Digestive Disorders in the Tropics

Sören L. Becker, Peiling Yap, Ninon S. Horié, Emilie Alirol, Barbara Barbé, Nisha K. Bhatta, Narayan R. Bhattarai, Emmanuel Bottieau, Justin K. Chatigre, Jean T. Coulibaly, Hassan K. M. Fofana, Jan Jacobs, Prahlad Karki, Basudha Khanal, Stefanie Knopp, Kanika Koirala, Yodi Mahendradhata, Pascal Mertens, Fransiska Meyanti, Elsa H. Murhandarwati, Eliézer K. N’Goran, Rosanna W. Peeling, Bickram Pradhan, Raffaella Ravinetto, Suman Rijal, Moussa Sacko, Rénion Saye, Pierre H. H. Schneeberger, Céline Schurmans, Kigbafori D. Silué, Peter Steinmann, Harry van Loen, Kristien Verdonck, Lisette van Lieshout, Lutz von Müller, Joel A. Yao, Marleen Boelaert, François Chappuis, Katja Polman, Jürg Utzinger

PLOS Neglected Tropical Diseases: published November 3, 2016 | https://doi.org/10.1371/journal.pntd.0004818

The Art of Writing and Implementing Standard Operating Procedures (SOPs) for Laboratories in Low-Resource Settings: Review of Guidelines and Best Practices

Barbara Barbé, Kristien Verdonck, Deby Mukendi, Veerle Lejon, Jean-Roger Lilo Kalo, Emilie Alirol, Philippe Gillet, Ninon Horié, Raffaella Ravinetto, Emmanuel Bottieau, Cedric Yansouni, Andrea S. Winkler, Harry van Loen, Marleen Boelaert, Pascal Lutumba, Jan Jacobs

PLOS Neglected Tropical Diseases: published November 3, 2016 | https://doi.org/10.1371/journal.pntd.0005053

Review

Comparative Bioinformatics Analysis of Transcription Factor Genes Indicates Conservation of Key Regulatory Domains among Babesia bovis, Babesia microti, and Theileria equi

Heba F. Alzan, Donald P. Knowles, Carlos E. Suarez

PLOS Neglected Tropical Diseases: published November 10, 2016 | https://doi.org/10.1371/journal.pntd.0004983

Research Articles

Transmission of Leishmania infantum in the Canine Leishmaniasis Focus of Mont-Rolland, Senegal: Ecological, Parasitological and Molecular Evidence for a Possible Role of Sergentomyia Sand Flies

Massila Wagué Senghor, Abdoul Aziz Niang, Jérome Depaquit, Hubert Ferté, Malick Ndao Faye, Eric Elguero, Oumar Gaye, Bulent Alten, Utku Perktas, Cécile Cassan, Babacar Faye, Anne-Laure Bañuls

PLOS Neglected Tropical Diseases: published November 2, 2016 | https://doi.org/10.1371/journal.pntd.0004940

Improving Coverage and Compliance in Mass Drug Administration for the Elimination of LF in Two ‘Endgame’ Districts in Indonesia Using Micronarrative Surveys

Alison Krentel, Rita Damayanti, Christiana Rialine Titaley, Nugroho Suharno, Mark Bradley, Timothy Lynam

PLOS Neglected Tropical Diseases: published November 3, 2016 | https://doi.org/10.1371/journal.pntd.0005027

Estimating the Burden of Chagas Disease in the United States

Jennifer Manne-Goehler, Chukwuemeka A. Umeh, Susan P. Montgomery, Veronika J. Wirtz

PLOS Neglected Tropical Diseases: published November 7, 2016 | https://doi.org/10.1371/journal.pntd.0005033

Biomarkers of Environmental Enteropathy are Positively Associated with Immune Responses to an Oral Cholera Vaccine in Bangladeshi Children

Muhammad Ikhtear Uddin, Shahidul Islam, Naoshin S. Nishat, Motaher Hossain, Tanzeem Ahmed Rafique, Rasheduzzaman Rashu, Mohammad Rubel Hoq, Yue Zhang, Amit Saha, Jason B. Harris, Stephen B. Calderwood, Taufiqur Rahman Bhuiyan, Edward T. Ryan, Daniel T. Leung, Firdausi Qadri

PLOS Neglected Tropical Diseases: published November 8, 2016 | https://doi.org/10.1371/journal.pntd.0005039

Snakebite Envenoming – A Combined Density Equalizing Mapping and Scientometric Analysis of the Publication History

David A. Groneberg, Victoria Geier, Doris Klingelhöfer, Alexander Gerber, Ulrich Kuch, Beatrix Kloft

PLOS Neglected Tropical Diseases: published November 7, 2016 | https://doi.org/10.1371/journal.pntd.0005046

One Health Interactions of Chagas Disease Vectors, Canid Hosts, and Human Residents along the Texas-Mexico Border

Melissa N. Garcia, Sarah O’Day, Susan Fisher-Hoch, Rodion Gorchakov, Ramiro Patino, Teresa P. Feria Arroyo, Susan T. Laing, Job E. Lopez, Alexandra Ingber, Kathryn M. Jones, Kristy O. Murray

PLOS Neglected Tropical Diseases: published November 10, 2016 | https://doi.org/10.1371/journal.pntd.0005074

Immunity to Lutzomyia whitmani Saliva Protects against Experimental Leishmania braziliensis Infection

Regis Gomes, Katrine Cavalcanti, Clarissa Teixeira, Augusto M. Carvalho, Paulo S. Mattos, Juqueline R. Cristal, Aline C. Muniz, José Carlos Miranda, Camila I. de Oliveira, Aldina Barral

PLOS Neglected Tropical Diseases: published November 3, 2016 | https://doi.org/10.1371/journal.pntd.0005078

Knowledge, Attitude and Practices of Vector-Borne Disease Prevention during the Emergence of a New Arbovirus: Implications for the Control of Chikungunya Virus in French Guiana

Camille Fritzell, Jocelyn Raude, Antoine Adde, Isabelle Dusfour, Philippe Quenel, Claude Flamand

PLOS Neglected Tropical Diseases: published November 1, 2016 | https://doi.org/10.1371/journal.pntd.0005081

Protein Translation Enzyme lysyl-tRNA Synthetase Presents a New Target for Drug Development against Causative Agents of Loiasis and Schistosomiasis

Arvind Sharma, Manmohan Sharma, Manickam Yogavel, Amit Sharma

PLOS Neglected Tropical Diseases: published November 2, 2016 | https://doi.org/10.1371/journal.pntd.0005084

Exploring Spatial and Temporal Distribution of Cutaneous Leishmaniasis in the Americas, 2001–2011

Ana Nilce Silveira Maia-Elkhoury, Zaida E. Yadón, Martha Idali Saboyá Díaz, Francisca de Fátima de Araújo Lucena, Luis Gerardo Castellanos, Manuel J. Sanchez-Vazquez

PLOS Neglected Tropical Diseases: published November 8, 2016 | https://doi.org/10.1371/journal.pntd.0005086

Minimally Symptomatic Infection in an Ebola ‘Hotspot’: A Cross-Sectional Serosurvey

Eugene T. Richardson, J. Daniel Kelly, Mohamed Bailor Barrie, Annelies W. Mesman, Sahr Karku, Komba Quiwa, Regan H. Marsh, Songor Koedoyoma, Fodei Daboh, Kathryn P. Barron, Michael Grady, Elizabeth Tucker, Kerry L. Dierberg, George W. Rutherford, Michele Barry, James Holland Jones, Megan B. Murray, Paul E. Farmer

PLOS Neglected Tropical Diseases: published November 15, 2016 | https://doi.org/10.1371/journal.pntd.0005087

CD4⁺ T Cells Are as Protective as CD8⁺ T Cells against Rickettsia typhi Infection by Activating Macrophage Bactericidal Activity

Kristin Moderzynski, Stefanie Papp, Jessica Rauch, Liza Heine, Svenja Kuehl, Ulricke Richardt, Bernhard Fleischer, Anke Osterloh

PLOS Neglected Tropical Diseases: published November 22, 2016 | https://doi.org/10.1371/journal.pntd.0005089

Containing Ebola at the Source with Ring Vaccination

Stefano Merler, Marco Ajelli, Laura Fumanelli, Stefano Parlamento, Ana Pastore y Piontti, Natalie E. Dean, Giovanni Putoto, Dante Carraro, Ira M. Longini Jr., M. Elizabeth Halloran, Alessandro Vespignani

PLOS Neglected Tropical Diseases: published November 2, 2016 | https://doi.org/10.1371/journal.pntd.0005093

The Epidemiological Characteristics and Dynamic Transmission of Dengue in China, 2013

Shaowei Sang, Shasha Wang, Liang lu, Peng Bi, Ming Lv, Qiyong Liu

PLOS Neglected Tropical Diseases: published November 7, 2016 | https://doi.org/10.1371/journal.pntd.0005095

The queenslandensis and the type Form of the Dengue Fever Mosquito (Aedes aegypti L.) Are Genomically Indistinguishable

Gordana Rašić, Igor Filipović, Ashley G. Callahan, Darren Stanford, Abigail Chan, Sai Gek Lam-Phua, Cheong Huat Tan, Ary Anthony Hoffmann

PLOS Neglected Tropical Diseases: published November 2, 2016 | https://doi.org/10.1371/journal.pntd.0005096

Molecular Epidemiology of Agents of Human Chromoblastomycosis in Brazil with the Description of Two Novel Species

Renata R. Gomes, Vania A. Vicente, Conceição M. P. S. de Azevedo, Claudio G. Salgado, Moises B. da Silva, Flávio Queiroz-Telles, Sirlei G. Marques, Daniel W. C. L. Santos, Tania S. de Andrade, Elizabeth H. Takagi, Katia S. Cruz, Gheniffer Fornari, Rosane C. Hahn, Maria L. Scroferneker, Rachel B. Caligine, Mauricio Ramirez-Castrillon, Daniella P. de Araújo, Daiane Heidrich, Arnaldo L. Colombo, G. S. de Hoog

PLOS Neglected Tropical Diseases: published November 28, 2016 | https://doi.org/10.1371/journal.pntd.0005102

Chronic Musculoskeletal Disabilities following Snake Envenoming in Sri Lanka: A Population-Based Study

Subashini Jayawardana, Ariaranee Gnanathasan, Carukshi Arambepola, Thashi Chang

PLOS Neglected Tropical Diseases: published November 4, 2016 | https://doi.org/10.1371/journal.pntd.0005103

Differential Protein Expression in the Hemolymph of Bithynia siamensis goniomphalos Infected with Opisthorchis viverrini

Kulwadee Suwannatrai, Apiporn Suwannatrai, Pairat Tabsripair, Jariya Umka Welbat, Sirikachorn Tangkawattana, Cinzia Cantacessi, Jason Mulvenna, Smarn Tesana, Alex Loukas, Javier Sotillo

PLOS Neglected Tropical Diseases: published November 28, 2016 | https://doi.org/10.1371/journal.pntd.0005104

Cholera in Cameroon, 2000-2012: Spatial and Temporal Analysis at the Operational (Health District) and Sub Climate Levels

Moise C. Ngwa, Song Liang, Ian T. Kracalik, Lillian Morris, Jason K. Blackburn, Leonard M. Mbam, Simon Franky Baonga Ba Pouth, Andrew Teboh, Yang Yang, Mouhaman Arabi, Jonathan D. Sugimoto, John Glenn Morris Jr.

PLOS Neglected Tropical Diseases: published November 17, 2016 | https://doi.org/10.1371/journal.pntd.0005105

A Cluster-Randomized Controlled Trial to Reduce Diarrheal Disease and Dengue Entomological Risk Factors in Rural Primary Schools in Colombia

Hans J. Overgaard, Neal Alexander, Maria Ines Matiz, Juan Felipe Jaramillo, Victor Alberto Olano, Sandra Vargas, Diana Sarmiento, Audrey Lenhart, Thor Axel Stenström

PLOS Neglected Tropical Diseases: published November 7, 2016 | https://doi.org/10.1371/journal.pntd.0005106

Identification and Validation of Small-Gatekeeper Kinases as Drug Targets in Giardia lamblia

Kelly M. Hennessey, Tess R. Smith, Jennifer W. Xu, Germain C. M. Alas, Kayode K. Ojo, Ethan A. Merritt, Alexander R. Paredez

PLOS Neglected Tropical Diseases: published November 2, 2016 | https://doi.org/10.1371/journal.pntd.0005107

Lymphatic Filariasis Elimination in American Samoa: Evaluation of Molecular Xenomonitoring as a Surveillance Tool in the Endgame

Colleen L. Lau, Kimberly Y. Won, Patrick J. Lammie, Patricia M. Graves

PLOS Neglected Tropical Diseases: published November 1, 2016 | https://doi.org/10.1371/journal.pntd.0005108

Migrant Workers in Malaysia: Current Implications of Sociodemographic and Environmental Characteristics in the Transmission of Intestinal Parasitic Infections

Norhidayu Sahimin, Yvonne A. L. Lim, Farnaza Ariffin, Jerzy M. Behnke, John W. Lewis, Siti Nursheena Mohd Zain

PLOS Neglected Tropical Diseases: published November 2, 2016 | https://doi.org/10.1371/journal.pntd.0005110

Ultrasonography of Leprosy Neuropathy: A Longitudinal Prospective Study

Helena Barbosa Lugão, Marco Andrey Cipriani Frade, Wilson Marques-Jr, Norma Tiraboschi Foss, Marcello Henrique Nogueira-Barbosa

PLOS Neglected Tropical Diseases: published November 16, 2016 | https://doi.org/10.1371/journal.pntd.0005111

Potential Risk Factors Associated with Human Cystic Echinococcosis: Systematic Review and Meta-analysis

Alessia Possenti, Raúl Manzano-Román, Carlos Sánchez-Ovejero, Belgees Boufana, Giuseppe La Torre, Mar Siles-Lucas, Adriano Casulli

PLOS Neglected Tropical Diseases: published November 7, 2016 | https://doi.org/10.1371/journal.pntd.0005114

Clinical Symptoms, Imaging Features and Cyst Distribution in the Cerebrospinal Fluid Compartments in Patients with Extraparenchymal Neurocysticercosis

Rodrigo Bazan, Pedro Tadao Hamamoto Filho, Gustavo José Luvizutto, Hélio Rubens de Carvalho Nunes, Newton Satoru Odashima, Antônio Carlos dos Santos, Jorge Elias Júnior, Marco Antônio Zanini, Agnès Fleury, Osvaldo Massaiti Takayanagui

PLOS Neglected Tropical Diseases: published November 9, 2016 | https://doi.org/10.1371/journal.pntd.0005115

Gene Expression Profile of High IFN-γ Producers Stimulated with Leishmania braziliensis Identifies Genes Associated with Cutaneous Leishmaniasis

Marcia W. Carneiro, Kiyoshi F. Fukutani, Bruno B. Andrade, Rebecca P. Curvelo, Juqueline R. Cristal, Augusto M. Carvalho, Aldina Barral, Johan Van Weyenbergh, Manoel Barral-Netto, Camila I. de Oliveira

PLOS Neglected Tropical Diseases: published November 21, 2016 | https://doi.org/10.1371/journal.pntd.0005116

High-Throughput Parallel Sequencing to Measure Fitness of Leptospira interrogans Transposon Insertion Mutants during Acute Infection

Kristel Lourdault, James Matsunaga, David A. Haake

PLOS Neglected Tropical Diseases: published November 8, 2016 | https://doi.org/10.1371/journal.pntd.0005117

Identifying Early Target Cells of Nipah Virus Infection in Syrian Hamsters

Laura Baseler, Dana P. Scott, Greg Saturday, Eva Horne, Rebecca Rosenke, Tina Thomas, Kimberly Meade-White, Elaine Haddock, Heinz Feldmann, Emmie de Wit

PLOS Neglected Tropical Diseases: published November 3, 2016 | https://doi.org/10.1371/journal.pntd.0005120

Seasonal and Spatial Environmental Influence on Opisthorchis viverrini Intermediate Hosts, Abundance, and Distribution: Insights on Transmission Dynamics and Sustainable Control

Christina Sunyoung Kim, Pierre Echaubard, Apiporn Suwannatrai, Sasithorn Kaewkes, Bruce A. Wilcox, Banchob Sripa

PLOS Neglected Tropical Diseases: published November 23, 2016 | https://doi.org/10.1371/journal.pntd.0005121

Selective Inhibitor of Nuclear Export (SINE) Compounds Alter New World Alphavirus Capsid Localization and Reduce Viral Replication in Mammalian Cells

Lindsay Lundberg, Chelsea Pinkham, Cynthia de la Fuente, Ashwini Brahms, Nazly Shafagati, Kylie M. Wagstaff, David A. Jans, Sharon Tamir, Kylene Kehn-Hall

PLOS Neglected Tropical Diseases: published November 30, 2016 | https://doi.org/10.1371/journal.pntd.0005122

Blood Transcriptional Profiling Reveals Immunological Signatures of Distinct States of Infection of Humans with Leishmania infantum

Luiz Gustavo Gardinassi, Gustavo Rocha Garcia, Carlos Henrique Nery Costa, Vladimir Costa Silva, Isabel Kinney Ferreira de Miranda Santos

PLOS Neglected Tropical Diseases: published November 9, 2016 | https://doi.org/10.1371/journal.pntd.0005123

Trypanosoma brucei CYP51: Essentiality and Targeting Therapy in an Experimental Model

Frédéric-Antoine Dauchy, Mélanie Bonhivers, Nicolas Landrein, Denis Dacheux, Pierrette Courtois, Florian Lauruol, Sylvie Daulouède, Philippe Vincendeau, Derrick R. Robinson

PLOS Neglected Tropical Diseases: published November 17, 2016 | https://doi.org/10.1371/journal.pntd.0005125

Screening of Fungi for Biological Control of a Triatomine Vector of Chagas Disease: Temperature and Trypanosome Infection as Factors

Aline R. M. Garcia, Adriana de Paula Rocha, Camila C. Moreira, Silma L. Rocha, Alessandra A. Guarneri, Simon L. Elliot

PLOS Neglected Tropical Diseases: published November 17, 2016 | https://doi.org/10.1371/journal.pntd.0005128

Use of the Health Belief Model for the Assessment of Public Knowledge and Household Preventive Practices in Karachi, Pakistan, a Dengue-Endemic City

Taranum Ruba Siddiqui, Saima Ghazal, Safia Bibi, Waquaruddin Ahmed, Shaimuna Fareeha Sajjad

PLOS Neglected Tropical Diseases: published November 10, 2016 | https://doi.org/10.1371/journal.pntd.0005129

A Genome Wide Comparison to Identify Markers to Differentiate the Sex of Larval Stages of Schistosoma haematobium, Schistosoma bovis and their Respective Hybrids

Julien Kincaid-Smith, Jérôme Boissier, Jean-François Allienne, Ana Oleaga, Félicité Djuikwo-Teukeng, Eve Toulza

PLOS Neglected Tropical Diseases: published November 18, 2016 | https://doi.org/10.1371/journal.pntd.0005138

Prevalence of Cutaneous Leishmaniasis in Districts of High and Low Endemicity in Mali

Bourama Traoré, Fabiano Oliveira, Ousmane Faye, Adama Dicko, Cheick A. Coulibaly, Ibrahim M. Sissoko, Samake Sibiry, Nafomon Sogoba, Moussa Brema Sangare, Yaya I. Coulibaly, Pierre Traore, Sekou F. Traore, Jennifer M. Anderson, Somita Keita, Jesus G. Valenzuela, Shaden Kamhawi, Seydou Doumbia

PLOS Neglected Tropical Diseases: published November 29, 2016 | https://doi.org/10.1371/journal.pntd.0005141

Maternal Filarial Infection Influences the Development of Regulatory T Cells in Children from Infancy to Early Childhood

Madhusmita Bal, Manoranjan Ranjit, K. Gopinath Achary, Ashok K. Satapathy

PLOS Neglected Tropical Diseases: published November 18, 2016 | https://doi.org/10.1371/journal.pntd.0005144

Wolbachia-Based Dengue Virus Inhibition Is Not Tissue-Specific in Aedes aegypti

Hilaria E. Amuzu, Elizabeth A. McGraw

PLOS Neglected Tropical Diseases: published November 17, 2016 | https://doi.org/10.1371/journal.pntd.0005145

Epidemiologic Correlates of Mortality among Symptomatic Visceral Leishmaniasis Cases: Findings from Situation Assessment in High Endemic Foci in India

Aritra Das, Morchan Karthick, Shweta Dwivedi, Indranath Banerjee, Tanmay Mahapatra, Sridhar Srikantiah, Indrajit Chaudhuri

PLOS Neglected Tropical Diseases: published November 21, 2016 | https://doi.org/10.1371/journal.pntd.0005150

Diet-Induced Nutritional Stress and Pathogen Interference in Wolbachia-Infected Aedes aegypti

Eric Pearce Caragata, Fernanda Oliveira Rezende, Taynãna César Simões, Luciano Andrade Moreira

PLOS Neglected Tropical Diseases: published November 28, 2016 | https://doi.org/10.1371/journal.pntd.0005158

Cover

One drug to kill them many

Editorial

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Viewpoints

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Symposiums

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Review

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