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February 2022

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The severe toll of morbidity and mortality wrought by SARS-CoV-2 infections, accompanied by very substantial indirect individual and societal impacts, have been felt worldwide since early 2020. Intensive scientific and medical progress has led to development of effective vaccines and other medical interventions, however, and these advances promise to protect and mitigate against further adverse effects of the COVID-19 pandemic. But when will these potential benefits be available worldwide, for all populations and in all countries? In an Editorial, the PLOS Medicine editors discuss the importance of global COVID-19 vaccine equity and describe some of the challenges to achieving it.

Image Credit: Caniceus, Pixabay

Editorial

Perspectives

Research Articles

Evaluation of low-dose aspirin in the prevention of recurrent spontaneous preterm labour (the APRIL study): A multicentre, randomised, double-blinded, placebo-controlled trial

Anadeijda J. E. M. C. Landman, Marjon A. de Boer, Laura Visser, Tobias A. J. Nijman, Marieke A. C. Hemels, Christiana N. Naaktgeboren, Marijke C. van der Weide, Ben W. Mol, Judith O. E. H. van Laar, Dimitri N. M. Papatsonis, Mireille N. Bekker, Joris van Drongelen, Mariëlle G. van Pampus, Marieke Sueters, David P. van der Ham, J. Marko Sikkema, Joost J. Zwart, Anjoke J. M. Huisjes, Marloes E. van Huizen, Gunilla Kleiverda, Janine Boon, Maureen T. M. Franssen, Wietske Hermes, Harry Visser, Christianne J. M. de Groot, Martijn A. Oudijk

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The impact of pictorial health warnings on purchases of sugary drinks for children: A randomized controlled trial

Marissa G. Hall, Anna H. Grummon, Isabella C. A. Higgins, Allison J. Lazard, Carmen E. Prestemon, Mirian I. Avendaño-Galdamez, Lindsey Smith Taillie

Obesity and risk of female reproductive conditions: A Mendelian randomisation study

Samvida S. Venkatesh, Teresa Ferreira, Stefania Benonisdottir, Nilufer Rahmioglu, Christian M. Becker, Ingrid Granne, Krina T. Zondervan, Michael V. Holmes, Cecilia M. Lindgren, Laura B. L. Wittemans

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Genetically proxied therapeutic inhibition of antihypertensive drug targets and risk of common cancers: A mendelian randomization analysis

James Yarmolinsky, Virginia Díez-Obrero, Tom G. Richardson, Marie Pigeyre, Jennifer Sjaarda, Guillaume Paré, Venexia M. Walker, Emma E. Vincent, Vanessa Y. Tan, Mireia Obón-Santacana, Demetrius Albanes, Jochen Hampe, Andrea Gsur, Heather Hampel, Rish K. Pai, Mark Jenkins, Steven Gallinger, Graham Casey, Wei Zheng, Christopher I. Amos, the International Lung Cancer Consortium, the PRACTICAL consortium, the MEGASTROKE consortium, George Davey Smith, Richard M. Martin, Victor Moreno

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Air quality improvement and cognitive decline in community-dwelling older women in the United States: A longitudinal cohort study

Diana Younan, Xinhui Wang, Joshua Millstein, Andrew J. Petkus, Daniel P. Beavers, Mark A. Espeland, Helena C. Chui, Susan M. Resnick, Margaret Gatz, Joel D. Kaufman, Gregory A. Wellenius, Eric A. Whitsel, JoAnn E. Manson, Stephen R. Rapp, Jiu-Chiuan Chen

Association of ischemic stroke onset time with presenting severity, acute progression, and long-term outcome: A cohort study

Wi-Sun Ryu, Keun-Sik Hong, Sang-Wuk Jeong, Jung E. Park, Beom Joon Kim, Joon-Tae Kim, Kyung Bok Lee, Tai Hwan Park, Sang-Soon Park, Jong-Moo Park, Kyusik Kang, Yong-Jin Cho, Hong-Kyun Park, Byung-Chul Lee, Kyung-Ho Yu, Mi Sun Oh, Soo Joo Lee, Jae Guk Kim, Jae-Kwan Cha, Dae-Hyun Kim, Jun Lee, Moon-Ku Han, Man Seok Park, Kang-Ho Choi, Juneyoung Lee, Jeffrey L. Saver, Eng H. Lo, Hee-Joon Bae, Dong-Eog Kim

Patient-reported outcomes and target effect sizes in pragmatic randomized trials in ClinicalTrials.gov: A cross-sectional analysis

Shelley Vanderhout, Dean A. Fergusson, Jonathan A. Cook, Monica Taljaard

Estimating impact of food choices on life expectancy: A modeling study

Lars T. Fadnes, Jan-Magnus Økland, Øystein A. Haaland, Kjell Arne Johansson

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Information nudges for influenza vaccination: Evidence from a large-scale cluster-randomized controlled trial in Finland

Lauri Sääksvuori, Cornelia Betsch, Hanna Nohynek, Heini Salo, Jonas Sivelä, Robert Böhm

Associations between lung function and physical and cognitive health in the Canadian Longitudinal Study on Aging (CLSA): A cross-sectional study from a multicenter national cohort

MyLinh Duong, Ali Usman, Jinhui Ma, Yangqing Xie, Julie Huang, Michele Zaman, Alex Dragoman, Steven Jiatong Chen, Malik Farooqi, Parminder Raina

Monetary incentives and peer referral in promoting secondary distribution of HIV self-testing among men who have sex with men in China: A randomized controlled trial

Yi Zhou, Ying Lu, Yuxin Ni, Dan Wu, Xi He, Jason J. Ong, Joseph D. Tucker, Sean Y. Sylvia, Fengshi Jing, Xiaofeng Li, Shanzi Huang, Guangquan Shen, Chen Xu, Yuan Xiong, Yongjie Sha, Mengyuan Cheng, Junjie Xu, Hongbo Jiang, Wencan Dai, Liqun Huang, Fei Zou, Cheng Wang, Bin Yang, Wenhua Mei, Weiming Tang

Excess years of life lost to COVID-19 and other causes of death by sex, neighbourhood deprivation, and region in England and Wales during 2020: A registry-based study

Evangelos Kontopantelis, Mamas A. Mamas, Roger T. Webb, Ana Castro, Martin K. Rutter, Chris P. Gale, Darren M. Ashcroft, Matthias Pierce, Kathryn M. Abel, Gareth Price, Corinne Faivre-Finn, Harriette G. C. Van Spall, Michelle M. Graham, Marcello Morciano, Glen P. Martin, Matt Sutton, Tim Doran

The global gap in treatment coverage for major depressive disorder in 84 countries from 2000–2019: A systematic review and Bayesian meta-regression analysis

Modhurima Moitra, Damian Santomauro, Pamela Y. Collins, Theo Vos, Harvey Whiteford, Shekhar Saxena, Alize J. Ferrari

Changes in household food and drink purchases following restrictions on the advertisement of high fat, salt, and sugar products across the Transport for London network: A controlled interrupted time series analysis

Amy Yau, Nicolas Berger, Cherry Law, Laura Cornelsen, Robert Greener, Jean Adams, Emma J. Boyland, Thomas Burgoine, Frank de Vocht, Matt Egan, Vanessa Er, Amelia A. Lake, Karen Lock, Oliver Mytton, Mark Petticrew, Claire Thompson, Martin White, Steven Cummins

Phylogeography and transmission of M. tuberculosis in Moldova: A prospective genomic analysis

Chongguang Yang, Benjamin Sobkowiak, Vijay Naidu, Alexandru Codreanu, Nelly Ciobanu, Kenneth S. Gunasekera, Melanie H. Chitwood, Sofia Alexandru, Stela Bivol, Marcus Russi, Joshua Havumaki, Patrick Cudahy, Heather Fosburgh, Christopher J. Allender, Heather Centner, David M. Engelthaler, Nicolas A. Menzies, Joshua L. Warren, Valeriu Crudu, Caroline Colijn, Ted Cohen

First dose ChAdOx1 and BNT162b2 COVID-19 vaccinations and cerebral venous sinus thrombosis: A pooled self-controlled case series study of 11.6 million individuals in England, Scotland, and Wales

Steven Kerr, Mark Joy, Fatemeh Torabi, Stuart Bedston, Ashley Akbari, Utkarsh Agrawal, Jillian Beggs, Declan Bradley, Antony Chuter, Annemarie B. Docherty, David Ford, Richard Hobbs, Srinivasa Vittal Katikireddi, Emily Lowthian, Simon de Lusignan, Ronan Lyons, James Marple, Colin McCowan, Dylan McGagh, Jim McMenamin, Emily Moore, Josephine-L. K. Murray, Rhiannon K. Owen, Jiafeng Pan, Lewis Ritchie, Syed Ahmar Shah, Ting Shi, Sarah Stock, Ruby S. M. Tsang, Eleftheria Vasileiou, Mark Woolhouse, Colin R. Simpson, Chris Robertson, Aziz Sheikh

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Association of COVID-19 vaccines ChAdOx1 and BNT162b2 with major venous, arterial, or thrombocytopenic events: A population-based cohort study of 46 million adults in England

William N. Whiteley, Samantha Ip, Jennifer A. Cooper, Thomas Bolton, Spencer Keene, Venexia Walker, Rachel Denholm, Ashley Akbari, Efosa Omigie, Sam Hollings, Emanuele Di Angelantonio, Spiros Denaxas, Angela Wood, Jonathan A. C. Sterne, Cathie Sudlow, CVD-COVID-UK consortium

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Uptake of infant and preschool immunisations in Scotland and England during the COVID-19 pandemic: An observational study of routinely collected data

Fiona McQuaid, Rachel Mulholland, Yuma Sangpang Rai, Utkarsh Agrawal, Helen Bedford, J. Claire Cameron, Cheryl Gibbons, Partho Roy, Aziz Sheikh, Ting Shi, Colin R. Simpson, Judith Tait, Elise Tessier, Steve Turner, Jaime Villacampa Ortega, Joanne White, Rachael Wood

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Global assessment of existing HIV and key population stigma indicators: A data mapping exercise to inform country-level stigma measurement

Carrie Lyons, Victoria Bendaud, Christine Bourey, Taavi Erkkola, Ishwarya Ravichandran, Omar Syarif, Anne Stangl, Judy Chang, Laura Ferguson, Laura Nyblade, Joseph Amon, Alexandrina Iovita, Eglė Janušonytė, Pim Looze, Laurel Sprague, Keith Sabin, UNAIDS Task Team, Stefan Baral, Sarah M. Murray

Mortality risk prediction of high-sensitivity C-reactive protein in suspected acute coronary syndrome: A cohort study

Amit Kaura, Adam Hartley, Vasileios Panoulas, Ben Glampson, Anoop S. V. Shah, Jim Davies, Abdulrahim Mulla, Kerrie Woods, Joe Omigie, Anoop D. Shah, Mark R. Thursz, Paul Elliott, Harry Hemmingway, Bryan Williams, Folkert W. Asselbergs, Michael O’Sullivan, Graham M. Lord, Adam Trickey, Jonathan AC Sterne, Dorian O. Haskard, Narbeh Melikian, Darrel P. Francis, Wolfgang Koenig, Ajay M. Shah, Rajesh Kharbanda, Divaka Perera, Riyaz S. Patel, Keith M. Channon, Jamil Mayet, Ramzi Khamis

Cost-effectiveness of antenatal multiple micronutrients and balanced energy protein supplementation compared to iron and folic acid supplementation in India, Pakistan, Mali, and Tanzania: A dynamic microsimulation study

Nicole Young, Alison Bowman, Kjell Swedin, James Collins, Nathaniel D. Blair-Stahn, Paulina A. Lindstedt, Christopher Troeger, Abraham D. Flaxman

The relationship between congenital heart disease and cancer in Swedish children: A population-based cohort study

Christina-Evmorfia Kampitsi, Hanna Mogensen, Maria Feychting, Giorgio Tettamanti