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November 2019

Substance use and its consequences have major implications for health in most, perhaps all, settings worldwide—ranging from the pervasive effects of legally-consumed alcohol for people in many countries to the ongoing epidemic of opioid misuse and overdose affecting people in North America and elsewhere. Approaches to prevention and treatment of substance use and misuse span public health and medicine as well as criminal justice and legal systems, and the aim of PLOS Medicine’s Special Issue on Substance Use, Misuse and Dependence is to showcase research and debate in this important and challenging area.

In this month’s Editorial, Guest Editors Alexander Tsai, Margarita Alegria and Steffanie Strathdee discuss some of the papers in the accompanying Special Issue alongside broader issues in health policy and practice.

Image Credit: Jacksoncam, Flickr

Editorial

Addressing the context and consequences of substance use, misuse, and dependence: A global imperative

Alexander C. Tsai, Margarita Alegría, Steffanie A. Strathdee

Perspectives

Joint statement on EPA proposed rule and public availability of data (2019)

H. Holden Thorp, Magdalena Skipper, Veronique Kiermer, May Berenbaum, Deborah Sweet, Richard Horton

Policy Forum

Stigma as a fundamental hindrance to the United States opioid overdose crisis response

Alexander C. Tsai, Mathew V. Kiang, Michael L. Barnett, Leo Beletsky, Katherine M. Keyes, Emma E. McGinty, Laramie R. Smith, Steffanie A. Strathdee, Sarah E. Wakeman, Atheendar S. Venkataramani

Research Articles

Trends in prescription opioid use and dose trajectories before opioid use disorder or overdose in US adults from 2006 to 2016: A cross-sectional study

Yu-Jung Jenny Wei, Cheng Chen, Roger Fillingim, Siegfried O. Schmidt, Almut G. Winterstein

Prescription opioid use and misuse among adolescents and young adults in the United States: A national survey study

Joel D. Hudgins, John J. Porter, Michael C. Monuteaux, Florence T. Bourgeois

Substance use disorders in refugee and migrant groups in Sweden: A nationwide cohort study of 1.2 million people

Samantha Harris, Jennifer Dykxhoorn, Anna-Clara Hollander, Christina Dalman, James B. Kirkbride

Oxygen systems to improve clinical care and outcomes for children and neonates: A stepped-wedge cluster-randomised trial in Nigeria

Hamish R. Graham, Ayobami A. Bakare, Adejumoke I. Ayede, Amy Z. Gray, Barbara McPake, David Peel, Olatayo Olatinwo, Oladapo B. Oyewole, Eleanor F. G. Neal, Cattram D. Nguyen, Shamim A. Qazi, Rasa Izadnegahdar, John B. Carlin, Adegoke G. Falade, Trevor Duke

Suspected heroin-related overdoses incidents in Cincinnati, Ohio: A spatiotemporal analysis

Zehang Richard Li, Evaline Xie, Forrest W. Crawford, Joshua L. Warren, Kathryn McConnell, J. Tyler Copple, Tyler Johnson, Gregg S. Gonsalves

Testosterone replacement in young male cancer survivors: A 6-month double-blind randomised placebo-controlled trial

Jennifer S. Walsh, Helen Marshall, Isabelle L. Smith, Diana M. Greenfield, Jayne Swain, Emma Best, James Ashton, Julia M. Brown, Robert Huddart, Robert E. Coleman, John A. Snowden, Richard J. Ross

Variation in blood pressure and long-term risk of dementia: A population-based cohort study

Yuan Ma, Frank J. Wolters, Lori B. Chibnik, Silvan Licher, M. Arfan Ikram, Albert Hofman, M. Kamran Ikram

Risk factors, management, and outcomes of amniotic fluid embolism: A multicountry, population-based cohort and nested case-control study

Kathryn E. Fitzpatrick, Thomas van den Akker, Kitty W. M. Bloemenkamp, Catherine Deneux-Tharaux, Alexandra Kristufkova, Zhuoyang Li, Timme P. Schaap, Elizabeth A. Sullivan, Derek Tuffnell, Marian Knight

Related Articles

Associations of maternal quitting, reducing, and continuing smoking during pregnancy with longitudinal fetal growth: Findings from Mendelian randomization and parental negative control studies

Judith S. Brand, Romy Gaillard, Jane West, Rosemary R. C. McEachan, John Wright, Ellis Voerman, Janine F. Felix, Kate Tilling, Deborah A. Lawlor

Defining a recovery-oriented cascade of care for opioid use disorder: A community-driven, statewide cross-sectional assessment

Jesse L. Yedinak, William C. Goedel, Kimberly Paull, Rebecca Lebeau, Maxwell S. Krieger, Cheyenne Thompson, Ashley L. Buchanan, Tom Coderre, Rebecca Boss, Josiah D. Rich, Brandon D. L. Marshall

Frequency of cannabis and illicit opioid use among people who use drugs and report chronic pain: A longitudinal analysis

Stephanie Lake, Zach Walsh, Thomas Kerr, Ziva D. Cooper, Jane Buxton, Evan Wood, Mark A. Ware, M. J. Milloy

Current situation and progress toward the 2030 health-related Sustainable Development Goals in China: A systematic analysis

Shu Chen, Lei Guo, Zhan Wang, Wenhui Mao, Yanfeng Ge, Xiaohua Ying, Jing Fang, Qian Long, Qin Liu, Hao Xiang, Chenkai Wu, Chaowei Fu, Di Dong, Jiahui Zhang, Ju Sun, Lichun Tian, Limin Wang, Maigeng Zhou, Mei Zhang, Mengcen Qian, Wei Liu, Weixi Jiang, Wenmeng Feng, Xinying Zeng, Xiyu Ding, Xun Lei, Rachel Tolhurst, Ling Xu, Haidong Wang, Faye Ziegeweid, Scott Glenn, John S. Ji, Mary Story, Gavin Yamey, Shenglan Tang

Duration of type 2 diabetes and remission rates after bariatric surgery in Sweden 2007–2015: A registry-based cohort study

Anders Jans, Ingmar Näslund, Johan Ottosson, Eva Szabo, Erik Näslund, Erik Stenberg

Noncompletion and nonpublication of trials studying rare diseases: A cross-sectional analysis

Chris A. Rees, Natalie Pica, Michael C. Monuteaux, Florence T. Bourgeois

Supervised injection facility use and all-cause mortality among people who inject drugs in Vancouver, Canada: A cohort study

Mary Clare Kennedy, Kanna Hayashi, M-J Milloy, Evan Wood, Thomas Kerr

Long-term mortality in mothers of infants with neonatal abstinence syndrome: A population-based parallel-cohort study in England and Ontario, Canada

Astrid Guttmann, Ruth Blackburn, Abby Amartey, Limei Zhou, Linda Wijlaars, Natasha Saunders, Katie Harron, Maria Chiu, Ruth Gilbert

The CHIRPY DRAGON intervention in preventing obesity in Chinese primary-school--aged children: A cluster-randomised controlled trial

Bai Li, Miranda Pallan, Wei Jia Liu, Karla Hemming, Emma Frew, Rong Lin, Wei Liu, James Martin, Mandana Zanganeh, Kiya Hurley, Kar Keung Cheng, Peymane Adab

Opioid agonist treatment scale-up and the initiation of injection drug use: A dynamic modeling analysis

Charles Marks, Annick Borquez, Sonia Jain, Xiaoying Sun, Steffanie A. Strathdee, Richard S. Garfein, M-J Milloy, Kora DeBeck, Javier A. Cepeda, Dan Werb, Natasha K. Martin

The overweight and obesity transition from the wealthy to the poor in low- and middle-income countries: A survey of household data from 103 countries

Tara Templin, Tiago Cravo Oliveira Hashiguchi, Blake Thomson, Joseph Dieleman, Eran Bendavid