The new survivors and a new era for trauma research

Karim Brohi, Martin Schreiber

PLOS Medicine: published July 25, 2017 | https://doi.org/10.1371/journal.pmed.1002354

Cancer trials in sub-Saharan Africa: Aligning research and care

Satish Gopal

PLOS Medicine: published July 10, 2017 | https://doi.org/10.1371/journal.pmed.1002351

Multidrug-resistant gonorrhea: A research and development roadmap to discover new medicines

Emilie Alirol, Teodora E. Wi, Manju Bala, Maria Luiza Bazzo, Xiang-Sheng Chen, Carolyn Deal, Jo-Anne R. Dillon, Ranmini Kularatne, Jutta Heim, Rob Hooft van Huijsduijnen, Edward W. Hook, Monica M. Lahra, David A. Lewis, Francis Ndowa, William M. Shafer, Liz Tayler, Kimberly Workowski, Magnus Unemo, Manica Balasegaram

PLOS Medicine: published July 26, 2017 | https://doi.org/10.1371/journal.pmed.1002366

Major scientific lessons learned in the trauma field over the last two decades

John B. Holcomb

PLOS Medicine: published July 5, 2017 | https://doi.org/10.1371/journal.pmed.1002339

Time for trauma immunology

Timothy R. Billiar, Yoram Vodovotz

PLOS Medicine: published July 11, 2017 | https://doi.org/10.1371/journal.pmed.1002342

Cellular therapies in trauma and critical care medicine: Looking towards the future

Shibani Pati, Todd E. Rasmussen

PLOS Medicine: published July 11, 2017 | https://doi.org/10.1371/journal.pmed.1002343

Research questions in pre-hospital trauma care

David J. Lockey

PLOS Medicine: published July 18, 2017 | https://doi.org/10.1371/journal.pmed.1002345

Trauma care: Finding a better way

Hasan B. Alam

PLOS Medicine: published July 18, 2017 | https://doi.org/10.1371/journal.pmed.1002350

The science of rapid start—From the when to the how of antiretroviral initiation

Elvin H. Geng, Diane V. Havlir

PLOS Medicine: published July 25, 2017 | https://doi.org/10.1371/journal.pmed.1002358

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Translational approaches to coagulopathy after trauma: Towards targeted treatment

Mitchell Jay Cohen

PLOS Medicine: published July 25, 2017 | https://doi.org/10.1371/journal.pmed.1002359

Reducing undiagnosed HIV infection among adolescents in sub-Saharan Africa: Provider-initiated and opt-out testing are not enough

Marguerita Lightfoot, Megan Dunbar, Sheri D. Weiser

PLOS Medicine: published July 25, 2017 | https://doi.org/10.1371/journal.pmed.1002361

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Leveraging peer-based support to facilitate HIV care in Kenya

Rakhi Karwa, Mercy Maina, Timothy Mercer, Benson Njuguna, Juddy Wachira, Celia Ngetich, Fatma Some, Beatrice Jakait, Regina K. Owino, Adrian Gardner, Sonak Pastakia

PLOS Medicine: published July 14, 2017 | https://doi.org/10.1371/journal.pmed.1002355

Antimicrobial resistance in Neisseria gonorrhoeae: Global surveillance and a call for international collaborative action

Teodora Wi, Monica M. Lahra, Francis Ndowa, Manju Bala, Jo-Anne R. Dillon, Pilar Ramon-Pardo, Sergey R. Eremin, Gail Bolan, Magnus Unemo

PLOS Medicine: published July 7, 2017 | https://doi.org/10.1371/journal.pmed.1002344

Ammonium tetrathiomolybdate following ischemia/reperfusion injury: Chemistry, pharmacology, and impact of a new class of sulfide donor in preclinical injury models

Alex Dyson, Felipe Dal-Pizzol, Giovanni Sabbatini, Anna B. Lach, Federica Galfo, Juliano dos Santos Cardoso, Bruna Pescador Mendonça, Iain Hargreaves, Bernardo Bollen Pinto, Daniel I. Bromage, John F. Martin, Kevin P. Moore, Martin Feelisch, Mervyn Singer

PLOS Medicine: published July 5, 2017 | https://doi.org/10.1371/journal.pmed.1002310

Risk of hospitalization with neurodegenerative disease after moderate-to-severe traumatic brain injury in the working-age population: A retrospective cohort study using the Finnish national health registries

Rahul Raj, Jaakko Kaprio, Miikka Korja, Era D. Mikkonen, Pekka Jousilahti, Jari Siironen

PLOS Medicine: published July 5, 2017 | https://doi.org/10.1371/journal.pmed.1002316

Long-term health status and trajectories of seriously injured patients: A population-based longitudinal study

Belinda J. Gabbe, Pam M. Simpson, Peter A. Cameron, Jennie Ponsford, Ronan A. Lyons, Alex Collie, Mark Fitzgerald, Rodney Judson, Warwick J. Teague, Sandra Braaf, Andrew Nunn, Shanthi Ameratunga, James E. Harrison

PLOS Medicine: published July 5, 2017 | https://doi.org/10.1371/journal.pmed.1002322

Community health promotion and medical provision for neonatal health—CHAMPION cluster randomised trial in Nagarkurnool district, Telangana (formerly Andhra Pradesh), India

Peter Boone, Alex Eble, Diana Elbourne, Chris Frost, Chitra Jayanty, Rashmi Lakshminarayana, Vera Mann, Rohini Mukherjee, Gilda Piaggio, Padmanabh Reddy

PLOS Medicine: published July 5, 2017 | https://doi.org/10.1371/journal.pmed.1002324

Timing of femoral shaft fracture fixation following major trauma: A retrospective cohort study of United States trauma centers

James P. Byrne, Avery B. Nathens, David Gomez, Daniel Pincus, Richard J. Jenkinson

PLOS Medicine: published July 5, 2017 | https://doi.org/10.1371/journal.pmed.1002336

Risk of surgical site infection, acute kidney injury, and Clostridium difficile infection following antibiotic prophylaxis with vancomycin plus a beta-lactam versus either drug alone: A national propensity-score-adjusted retrospective cohort study

Westyn Branch-Elliman, John E. Ripollone, William J. O’Brien, Kamal M. F. Itani, Marin L. Schweizer, Eli Perencevich, Judith Strymish, Kalpana Gupta

PLOS Medicine: published July 10, 2017 | https://doi.org/10.1371/journal.pmed.1002340

Patient-reported outcomes and survival in multiple sclerosis: A 10-year retrospective cohort study using the Multiple Sclerosis Impact Scale–29

Joel Raffel, Alison Wallace, Djordje Gveric, Richard Reynolds, Tim Friede, Richard Nicholas

PLOS Medicine: published July 10, 2017 | https://doi.org/10.1371/journal.pmed.1002346

Validation of the sensitivity of the National Emergency X-Radiography Utilization Study (NEXUS) Head computed tomographic (CT) decision instrument for selective imaging of blunt head injury patients: An observational study

William R. Mower, Malkeet Gupta, Robert Rodriguez, Gregory W. Hendey

PLOS Medicine: published July 11, 2017 | https://doi.org/10.1371/journal.pmed.1002313

Years of life lost due to traumatic brain injury in Europe: A cross-sectional analysis of 16 countries

Marek Majdan, Dominika Plancikova, Andrew Maas, Suzanne Polinder, Valery Feigin, Alice Theadom, Martin Rusnak, Alexandra Brazinova, Juanita Haagsma

PLOS Medicine: published July 11, 2017 | https://doi.org/10.1371/journal.pmed.1002331

Trends in traumatic brain injury mortality in China, 2006–2013: A population-based longitudinal study

Peixia Cheng, Peng Yin, Peishan Ning, Lijun Wang, Xunjie Cheng, Yunning Liu, David C. Schwebel, Jiangmei Liu, Jinlei Qi, Guoqing Hu, Maigeng Zhou

PLOS Medicine: published July 11, 2017 | https://doi.org/10.1371/journal.pmed.1002332

Community and health system intervention to reduce disrespect and abuse during childbirth in Tanga Region, Tanzania: A comparative before-and-after study

Stephanie A. Kujawski, Lynn P. Freedman, Kate Ramsey, Godfrey Mbaruku, Selemani Mbuyita, Wema Moyo, Margaret E. Kruk

PLOS Medicine: published July 11, 2017 | https://doi.org/10.1371/journal.pmed.1002341

Signatures of inflammation and impending multiple organ dysfunction in the hyperacute phase of trauma: A prospective cohort study

Claudia P. Cabrera, Joanna Manson, Joanna M. Shepherd, Hew D. Torrance, David Watson, M. Paula Longhi, Mimoza Hoti, Minal B. Patel, Michael O’Dwyer, Sussan Nourshargh, Daniel J. Pennington, Michael R. Barnes, Karim Brohi

PLOS Medicine: published July 17, 2017 | https://doi.org/10.1371/journal.pmed.1002352

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Jon Hazeldine, David N. Naumann, Emma Toman, David Davies, Jonathan R. B. Bishop, Zhangjie Su, Peter Hampson, Robert J. Dinsdale, Nicholas Crombie, Niharika Arora Duggal, Paul Harrison, Antonio Belli, Janet M. Lord

PLOS Medicine: published July 18, 2017 | https://doi.org/10.1371/journal.pmed.1002338

Prescription medicine use by pedestrians and the risk of injurious road traffic crashes: A case-crossover study

Mélanie Née, Marta Avalos, Audrey Luxcey, Benjamin Contrand, Louis-Rachid Salmi, Annie Fourrier-Réglat, Blandine Gadegbeku, Emmanuel Lagarde, Ludivine Orriols

PLOS Medicine: published July 18, 2017 | https://doi.org/10.1371/journal.pmed.1002347

Cerebrovascular pressure reactivity monitoring using wavelet analysis in traumatic brain injury patients: A retrospective study

Xiuyun Liu, Joseph Donnelly, Marek Czosnyka, Marcel J. H. Aries, Ken Brady, Danilo Cardim, Chiara Robba, Manuel Cabeleira, Dong-Joo Kim, Christina Haubrich, Peter J. Hutchinson, Peter Smielewski

PLOS Medicine: published July 25, 2017 | https://doi.org/10.1371/journal.pmed.1002348

A comparison of Selective Aortic Arch Perfusion and Resuscitative Endovascular Balloon Occlusion of the Aorta for the management of hemorrhage-induced traumatic cardiac arrest: A translational model in large swine

Ed B. G. Barnard, James E. Manning, Jason E. Smith, Jason M. Rall, Jennifer M. Cox, James D. Ross

PLOS Medicine: published July 25, 2017 | https://doi.org/10.1371/journal.pmed.1002349

Temporal profile of intracranial pressure and cerebrovascular reactivity in severe traumatic brain injury and association with fatal outcome: An observational study

Hadie Adams, Joseph Donnelly, Marek Czosnyka, Angelos G. Kolias, Adel Helmy, David K. Menon, Peter Smielewski, Peter J. Hutchinson

PLOS Medicine: published July 25, 2017 | https://doi.org/10.1371/journal.pmed.1002353

Ultrasound non-invasive measurement of intracranial pressure in neurointensive care: A prospective observational study

Chiara Robba, Danilo Cardim, Tamara Tajsic, Justine Pietersen, Michael Bulman, Joseph Donnelly, Andrea Lavinio, Arun Gupta, David K. Menon, Peter J. A. Hutchinson, Marek Czosnyka

PLOS Medicine: published July 25, 2017 | https://doi.org/10.1371/journal.pmed.1002356

Same-day HIV testing with initiation of antiretroviral therapy versus standard care for persons living with HIV: A randomized unblinded trial

Serena P. Koenig, Nancy Dorvil, Jessy G. Dévieux, Bethany L. Hedt-Gauthier, Cynthia Riviere, Mikerlyne Faustin, Kerlyne Lavoile, Christian Perodin, Alexandra Apollon, Limathe Duverger, Margaret L. McNairy, Kelly A. Hennessey, Ariadne Souroutzidis, Pierre-Yves Cremieux, Patrice Severe, Jean W. Pape

PLOS Medicine: published July 25, 2017 | https://doi.org/10.1371/journal.pmed.1002357

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PLOS Medicine: published July 25, 2017 | https://doi.org/10.1371/journal.pmed.1002360

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IL33-mediated ILC2 activation and neutrophil IL5 production in the lung response after severe trauma: A reverse translation study from a human cohort to a mouse trauma model

Jing Xu, Jesse Guardado, Rosemary Hoffman, Hui Xu, Rami Namas, Yoram Vodovotz, Li Xu, Mostafa Ramadan, Joshua Brown, Heth R. Turnquist, Timothy R. Billiar

PLOS Medicine: published July 25, 2017 | https://doi.org/10.1371/journal.pmed.1002365