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Table of Contents

March 2015

Cover

Testing and Treating the Missing Millions with Tuberculosis
Issue Image

The theme for World TB Day 2015 is "Reach, Treat, Cure Everyone."

Currently, of the estimated 9 million people who develop TB worldwide each year, about one-third are not diagnosed, treated, or tracked by national TB programs.

In a Guest Editorial on World TB Day, Madhukar Pai and Puneet Dewan identify programmatic and policy changes needed to accelerate progress towards the goal of ending TB by 2035.

Image Credit: Madhukar Pai

Editorial

Testing and Treating the Missing Millions with Tuberculosis

Madhukar Pai, Puneet Dewan

PLOS Medicine: published March 24, 2015 | https://doi.org/10.1371/journal.pmed.1001805

Perspective

Role of Acute HIV Infection in Driving HIV Transmission: Implications for HIV Treatment as Prevention

Laith J. Abu-Raddad

PLOS Medicine: published March 17, 2015 | https://doi.org/10.1371/journal.pmed.1001803

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  1. Reassessment of HIV-1 Acute Phase Infectivity: Accounting for Heterogeneity and Study Design with Simulated Cohorts

Health in Action

UK Biobank: An Open Access Resource for Identifying the Causes of a Wide Range of Complex Diseases of Middle and Old Age

Cathie Sudlow, John Gallacher, Naomi Allen, Valerie Beral, Paul Burton, John Danesh, Paul Downey, Paul Elliott, Jane Green, Martin Landray, Bette Liu, Paul Matthews, Giok Ong, Jill Pell, Alan Silman, Alan Young, Tim Sprosen, Tim Peakman, Rory Collins

PLOS Medicine: published March 31, 2015 | https://doi.org/10.1371/journal.pmed.1001779

Policy Forums

A Public Health Approach to Hepatitis C Control in Low- and Middle-Income Countries

Amitabh B. Suthar, Anthony D. Harries

PLOS Medicine: published March 10, 2015 | https://doi.org/10.1371/journal.pmed.1001795

Paying Physicians to Prescribe Generic Drugs and Follow-On Biologics in the United States

Ameet Sarpatwari, Niteesh K. Choudhry, Jerry Avorn, Aaron S. Kesselheim

PLOS Medicine: published March 17, 2015 | https://doi.org/10.1371/journal.pmed.1001802

Strengthening the Detection of and Early Response to Public Health Emergencies: Lessons from the West African Ebola Epidemic

Mark J. Siedner, Lawrence O. Gostin, Hilarie H. Cranmer, John D. Kraemer

PLOS Medicine: published March 24, 2015 | https://doi.org/10.1371/journal.pmed.1001804

Research Articles

Ultra-Sensitive Detection of Plasmodium falciparum by Amplification of Multi-Copy Subtelomeric Targets

Natalie Hofmann, Felista Mwingira, Seif Shekalaghe, Leanne J. Robinson, Ivo Mueller, Ingrid Felger

PLOS Medicine: published March 3, 2015 | https://doi.org/10.1371/journal.pmed.1001788

Association between Traffic-Related Air Pollution in Schools and Cognitive Development in Primary School Children: A Prospective Cohort Study

Jordi Sunyer, Mikel Esnaola, Mar Alvarez-Pedrerol, Joan Forns, Ioar Rivas, Mònica López-Vicente, Elisabet Suades-González, Maria Foraster, Raquel Garcia-Esteban, Xavier Basagaña, Mar Viana, Marta Cirach, Teresa Moreno, Andrés Alastuey, Núria Sebastian-Galles, Mark Nieuwenhuijsen, Xavier Querol

PLOS Medicine: published March 3, 2015 | https://doi.org/10.1371/journal.pmed.1001792

CD47 Agonist Peptides Induce Programmed Cell Death in Refractory Chronic Lymphocytic Leukemia B Cells via PLCγ1 Activation: Evidence from Mice and Humans

Ana-Carolina Martinez-Torres, Claire Quiney, Tarik Attout, Heloïse Boullet, Linda Herbi, Laura Vela, Sandrine Barbier, Danielle Chateau, Elise Chapiro, Florence Nguyen-Khac, Frédéric Davi, Magali Le Garff-Tavernier, Roba Moumné, Marika Sarfati, Philippe Karoyan, Hélène Merle-Béral, Pierre Launay, Santos A. Susin

PLOS Medicine: published March 3, 2015 | https://doi.org/10.1371/journal.pmed.1001796

Sugar Industry Influence on the Scientific Agenda of the National Institute of Dental Research’s 1971 National Caries Program: A Historical Analysis of Internal Documents

Cristin E. Kearns, Stanton A. Glantz, Laura A. Schmidt

PLOS Medicine: published March 10, 2015 | https://doi.org/10.1371/journal.pmed.1001798

Reassessment of HIV-1 Acute Phase Infectivity: Accounting for Heterogeneity and Study Design with Simulated Cohorts

Steve E. Bellan, Jonathan Dushoff, Alison P. Galvani, Lauren Ancel Meyers

PLOS Medicine: published March 17, 2015 | https://doi.org/10.1371/journal.pmed.1001801

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  1. Role of Acute HIV Infection in Driving HIV Transmission: Implications for HIV Treatment as Prevention

Broad Blockade Antibody Responses in Human Volunteers after Immunization with a Multivalent Norovirus VLP Candidate Vaccine: Immunological Analyses from a Phase I Clinical Trial

Lisa C. Lindesmith, Martin T. Ferris, Clancy W. Mullan, Jennifer Ferreira, Kari Debbink, Jesica Swanstrom, Charles Richardson, Robert R. Goodwin, Frank Baehner, Paul M. Mendelman, Robert F. Bargatze, Ralph S. Baric

PLOS Medicine: published March 24, 2015 | https://doi.org/10.1371/journal.pmed.1001807

Development and Validation of a Risk Score for Chronic Kidney Disease in HIV Infection Using Prospective Cohort Data from the D:A:D Study

Amanda Mocroft, Jens D. Lundgren, Michael Ross, Matthew Law, Peter Reiss, Ole Kirk, Colette Smith, Deborah Wentworth, Jacqueline Neuhaus, Christoph A. Fux, Olivier Moranne, Phillipe Morlat, Margaret A. Johnson, Lene Ryom, D:A:D study group, the Royal Free Hospital Clinic Cohort, and the INSIGHT, SMART, and ESPRIT study groups

PLOS Medicine: published March 31, 2015 | https://doi.org/10.1371/journal.pmed.1001809

Formal Comments

HIV Treatment-As-Prevention Research: Authors’ Reply

Till Bärnighausen, Nir Eyal, Dan Wikler

PLOS Medicine: published March 10, 2015 | https://doi.org/10.1371/journal.pmed.1001799

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  1. HIV Treatment-As-Prevention Research: Taking the Right Road at the Crossroads
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HIV Treatment-As-Prevention Research: Taking the Right Road at the Crossroads

Richard Hayes, Sarah Fidler, Anne Cori, Christophe Fraser, Sian Floyd, Helen Ayles, Nulda Beyers, Wafaa El-Sadr, HPTN 071 (PopART) Study Team

PLOS Medicine: published March 10, 2015 | https://doi.org/10.1371/journal.pmed.1001800

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