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Table of Contents

February 2015

Cover

Open Access to Large Scale Datasets Is Needed to Translate Knowledge of Cancer Heterogeneity into Better Patient Outcomes
Issue Image

The February Issue of PLOS Medicine includes two studies that relate intratumoral heterogeneity to clinical cancer outcomes. James Rocco and colleagues analyzed data from The Cancer Genome Atlas (TCGA) to show that tumor heterogeneity can serve as a prognostic indicator in head and neck squamous cell carcinoma (HNSCC), and James Brenton and colleagues found higher levels of tumor heterogeneity to be associated with decreased survival in serous ovarian cancer.

In a Guest Editorial, Andrew Beck of Harvard Medical School discusses how these two studies support the idea that molecular characterization of large sets of cancer samples can lead to improved personalized therapies for cancer.

Image Credit: Christian Schnettelker, Flickr

Editorials

PLOS Medicine 2014 Reviewer Thank You

PLOS Medicine: published February 27, 2015 | https://doi.org/10.1371/journal.pmed.1001806

Open Access to Large Scale Datasets Is Needed to Translate Knowledge of Cancer Heterogeneity into Better Patient Outcomes

Andrew H. Beck

PLOS Medicine: published February 24, 2015 | https://doi.org/10.1371/journal.pmed.1001794

Essay

Humanitarian Access to Unapproved Interventions in Public Health Emergencies of International Concern

Jerome Amir Singh

PLOS Medicine: published February 24, 2015 | https://doi.org/10.1371/journal.pmed.1001793

Health in Action

Enabling Dynamic Partnerships through Joint Degrees between Low- and High-Income Countries for Capacity Development in Global Health Research: Experience from the Karolinska Institutet/Makerere University Partnership

Nelson Sewankambo, James K. Tumwine, Göran Tomson, Celestino Obua, Freddie Bwanga, Peter Waiswa, Elly Katabira, Hannah Akuffo, Kristina Persson, Stefan Peterson

PLOS Medicine: published February 3, 2015 | https://doi.org/10.1371/journal.pmed.1001784

Related Articles

  1. Correction: Enabling Dynamic Partnerships through Joint Degrees between Low- and High-Income Countries for Capacity Development in Global Health Research: Experience from the Karolinska Institutet/Makerere University Partnership

Policy Forum

The Movement of Multidrug-Resistant Tuberculosis across Borders in East Africa Needs a Regional and Global Solution

Kevin P. Cain, Nina Marano, Maureen Kamene, Joseph Sitienei, Subroto Mukherjee, Aleksandar Galev, John Burton, Orkhan Nasibov, Jackson Kioko, Kevin M. De Cock

PLOS Medicine: published February 24, 2015 | https://doi.org/10.1371/journal.pmed.1001791

Research Articles

Spatial and Temporal Heterogeneity in High-Grade Serous Ovarian Cancer: A Phylogenetic Analysis

Roland F. Schwarz, Charlotte K. Y. Ng, Susanna L. Cooke, Scott Newman, Jillian Temple, Anna M. Piskorz, Davina Gale, Karen Sayal, Muhammed Murtaza, Peter J. Baldwin, Nitzan Rosenfeld, Helena M. Earl, Evis Sala, Mercedes Jimenez-Linan, Christine A. Parkinson, Florian Markowetz, James D. Brenton

PLOS Medicine: published February 24, 2015 | https://doi.org/10.1371/journal.pmed.1001789

A Primary Care Nurse-Delivered Walking Intervention in Older Adults: PACE (Pedometer Accelerometer Consultation Evaluation)-Lift Cluster Randomised Controlled Trial

Tess Harris, Sally M. Kerry, Christina R. Victor, Ulf Ekelund, Alison Woodcock, Steve Iliffe, Peter H. Whincup, Carole Beighton, Michael Ussher, Elizabeth S. Limb, Lee David, Debbie Brewin, Fredrika Adams, Annabelle Rogers, Derek G. Cook

PLOS Medicine: published February 17, 2015 | https://doi.org/10.1371/journal.pmed.1001783

Complaints, Complainants, and Rulings Regarding Drug Promotion in the United Kingdom and Sweden 2004–2012: A Quantitative and Qualitative Study of Pharmaceutical Industry Self-Regulation

Anna V. Zetterqvist, Juan Merlo, Shai Mulinari

PLOS Medicine: published February 17, 2015 | https://doi.org/10.1371/journal.pmed.1001785

Intra-tumor Genetic Heterogeneity and Mortality in Head and Neck Cancer: Analysis of Data from The Cancer Genome Atlas

Edmund A. Mroz, Aaron M. Tward, Rebecca J. Hammon, Yin Ren, James W. Rocco

PLOS Medicine: published February 10, 2015 | https://doi.org/10.1371/journal.pmed.1001786

Related Articles

  1. Correction: Intra-tumor Genetic Heterogeneity and Mortality in Head and Neck Cancer: Analysis of Data from The Cancer Genome Atlas
  2. Correction: Intra-tumor Genetic Heterogeneity and Mortality in Head and Neck Cancer: Analysis of Data from The Cancer Genome Atlas

The Role of Abcb5 Alleles in Susceptibility to Haloperidol-Induced Toxicity in Mice and Humans

Ming Zheng, Haili Zhang, David L. Dill, J. David Clark, Susan Tu, Arielle L. Yablonovitch, Meng How Tan, Rui Zhang, Dan Rujescu, Manhong Wu, Lino Tessarollo, Wilfred Vieira, Michael M. Gottesman, Suhua Deng, Livia S. Eberlin, Richard N. Zare, Jean-Martin Billard, Jean-Pierre Gillet, Jin Billy Li, Gary Peltz

PLOS Medicine: published February 3, 2015 | https://doi.org/10.1371/journal.pmed.1001782