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Table of Contents

April 2007

Cover

Lethal Injection Is Not Humane.
Issue Image

The cover image takes its theme from the paper by Leonidas Koniaris and colleagues. Data from executions in the US suggest that current lethal injection protocols do not effect death through the mechanisms intended, and that potentially aware inmates could die through pancuronium-induced asphyxiation. The humaneness of lethal injection is discussed further in the accompanying Editorial.

Image Credit: Image provided by California Department of Corrections and Rehabilitation

Editorial

Lethal Injection Is Not Humane

The PLoS Medicine Editors

PLOS Medicine: published April 24, 2007 | https://doi.org/10.1371/journal.pmed.0040171

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Essays

Medicines without Doctors: Why the Global Fund Must Fund Salaries of Health Workers to Expand AIDS Treatment

Gorik Ooms, Wim Van Damme, Marleen Temmerman

PLOS Medicine: published April 17, 2007 | https://doi.org/10.1371/journal.pmed.0040128

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Reducing Medical Costs and Improving Quality via Self-Management Tools

Harold J DeMonaco, Eric von Hippel

PLOS Medicine: published April 17, 2007 | https://doi.org/10.1371/journal.pmed.0040104

Perspectives

Does Restricting Pack Size of Paracetamol (Acetaminophen) Reduce Suicides?

Nicholas A Buckley, David Gunnell

PLOS Medicine: published April 3, 2007 | https://doi.org/10.1371/journal.pmed.0040152

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  1. Interrupted Time-Series Analysis of Regulations to Reduce Paracetamol (Acetaminophen) Poisoning

Rotavirus Infection: A Systemic Illness?

David C. A Candy

PLOS Medicine: published April 17, 2007 | https://doi.org/10.1371/journal.pmed.0040117

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  1. Rotavirus Antigenemia in Children Is Associated with Viremia

Comparing Alcohol Policies Between Countries: Science or Silliness?

Alison Ritter

PLOS Medicine: published April 24, 2007 | https://doi.org/10.1371/journal.pmed.0040153

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  1. Comparative Analysis of Alcohol Control Policies in 30 Countries

Type 2 Diabetes: Hypoinsulinism, Hyperinsulinism, or Both?

Benjamin Glaser

PLOS Medicine: published April 3, 2007 | https://doi.org/10.1371/journal.pmed.0040148

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Policy Forums

Following the Script: How Drug Reps Make Friends and Influence Doctors

Adriane Fugh-Berman, Shahram Ahari

PLOS Medicine: published April 24, 2007 | https://doi.org/10.1371/journal.pmed.0040150

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  1. Characteristics and Impact of Drug Detailing for Gabapentin

Addressing the Global Neglect of Childhood Hearing Impairment in Developing Countries

Bolajoko O Olusanya

PLOS Medicine: published April 3, 2007 | https://doi.org/10.1371/journal.pmed.0040074

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  1. Correction: Addressing the Global Neglect of Childhood Hearing Impairment in Developing Countries

Malaria in Pregnancy: What Can the Social Sciences Contribute?

Joan Muela Ribera, Susanna Hausmann-Muela, Umberto D'Alessandro, Koen Peeters Grietens

PLOS Medicine: published April 10, 2007 | https://doi.org/10.1371/journal.pmed.0040092

Valid Consent for Genomic Epidemiology in Developing Countries

Dave A Chokshi, Mahamadou A Thera, Michael Parker, Mahamadou Diakite, Julie Makani, Dominic P Kwiatkowski, Ogobara K Doumbo

PLOS Medicine: published April 24, 2007 | https://doi.org/10.1371/journal.pmed.0040095

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Case Report

A Man with Labile Blood Pressure

Ronald C. W Ma, Kwok Hing Yiu, Edward H. C Wong, Kin Hung Liu, Joseph Y. S Chan, Chun Chung Chow, Clive S Cockram

PLOS Medicine: published April 24, 2007 | https://doi.org/10.1371/journal.pmed.0040111

Research Articles

Lethal Injection for Execution: Chemical Asphyxiation?

Teresa A Zimmers, Jonathan Sheldon, David A Lubarsky, Francisco López-Muñoz, Linda Waterman, Richard Weisman, Leonidas G Koniaris

PLOS Medicine: published April 24, 2007 | https://doi.org/10.1371/journal.pmed.0040156

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Interrupted Time-Series Analysis of Regulations to Reduce Paracetamol (Acetaminophen) Poisoning

Oliver W Morgan, Clare Griffiths, Azeem Majeed

PLOS Medicine: published April 3, 2007 | https://doi.org/10.1371/journal.pmed.0040105

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Rotavirus Antigenemia in Children Is Associated with Viremia

Sarah E Blutt, David O Matson, Sue E Crawford, Mary Allen Staat, Parvin Azimi, Berkeley L Bennett, Pedro A Piedra, Margaret E Conner

PLOS Medicine: published April 17, 2007 | https://doi.org/10.1371/journal.pmed.0040121

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Antibody to Aquaporin 4 in the Diagnosis of Neuromyelitis Optica

Friedemann Paul, Sven Jarius, Orhan Aktas, Martin Bluthner, Oliver Bauer, Heribert Appelhans, Diego Franciotta, Roberto Bergamaschi, Edward Littleton, Jacqueline Palace, Hans-Peter Seelig, Reinhard Hohlfeld, Angela Vincent, Frauke Zipp

PLOS Medicine: published April 17, 2007 | https://doi.org/10.1371/journal.pmed.0040133

TREM2-Transduced Myeloid Precursors Mediate Nervous Tissue Debris Clearance and Facilitate Recovery in an Animal Model of Multiple Sclerosis

Kazuya Takahashi, Marco Prinz, Massimiliano Stagi, Olga Chechneva, Harald Neumann

PLOS Medicine: published April 10, 2007 | https://doi.org/10.1371/journal.pmed.0040124

Gene Expression Signatures That Predict Radiation Exposure in Mice and Humans

Holly K Dressman, Garrett G Muramoto, Nelson J Chao, Sarah Meadows, Dawn Marshall, Geoffrey S Ginsburg, Joseph R Nevins, John P Chute

PLOS Medicine: published April 3, 2007 | https://doi.org/10.1371/journal.pmed.0040106

Signature-Based Small Molecule Screening Identifies Cytosine Arabinoside as an EWS/FLI Modulator in Ewing Sarcoma

Kimberly Stegmaier, Jenny S Wong, Kenneth N Ross, Kwan T Chow, David Peck, Renee D Wright, Stephen L Lessnick, Andrew L Kung, Todd R Golub

PLOS Medicine: published April 10, 2007 | https://doi.org/10.1371/journal.pmed.0040122

Polymorphisms, Mutations, and Amplification of the EGFR Gene in Non-Small Cell Lung Cancers

Masaharu Nomura, Hisayuki Shigematsu, Lin Li, Makoto Suzuki, Takao Takahashi, Pila Estess, Mark Siegelman, Ziding Feng, Harubumi Kato, Antonio Marchetti, Jerry W Shay, Margaret R Spitz, Ignacio I Wistuba, John D Minna, Adi F Gazdar

PLOS Medicine: published April 24, 2007 | https://doi.org/10.1371/journal.pmed.0040125

Genetics of Ischaemic Stroke among Persons of Non-European Descent: A Meta-Analysis of Eight Genes Involving ∼ 32,500 Individuals

Roshan Ariyaratnam, Juan P Casas, John Whittaker, Liam Smeeth, Aroon D Hingorani, Pankaj Sharma

PLOS Medicine: published April 24, 2007 | https://doi.org/10.1371/journal.pmed.0040131

Earlier Mother's Age at Menarche Predicts Rapid Infancy Growth and Childhood Obesity

Ken K Ong, Kate Northstone, Jonathan CK Wells, Carol Rubin, Andy R Ness, Jean Golding, David B Dunger

PLOS Medicine: published April 24, 2007 | https://doi.org/10.1371/journal.pmed.0040132

Characteristics and Impact of Drug Detailing for Gabapentin

Michael A Steinman, G. Michael Harper, Mary-Margaret Chren, C. Seth Landefeld, Lisa A Bero

PLOS Medicine: published April 24, 2007 | https://doi.org/10.1371/journal.pmed.0040134

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Comparative Analysis of Alcohol Control Policies in 30 Countries

Donald A Brand, Michaela Saisana, Lisa A Rynn, Fulvia Pennoni, Albert B Lowenfels

PLOS Medicine: published April 24, 2007 | https://doi.org/10.1371/journal.pmed.0040151

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Macrosomia and Hyperinsulinaemic Hypoglycaemia in Patients with Heterozygous Mutations in the HNF4A Gene

Ewan R Pearson, Sylvia F Boj, Anna M Steele, Timothy Barrett, Karen Stals, Julian P Shield, Sian Ellard, Jorge Ferrer, Andrew T Hattersley

PLOS Medicine: published April 3, 2007 | https://doi.org/10.1371/journal.pmed.0040118

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Correspondence

XDR-TB in South Africa: Revised Definition

Timothy H Holtz

PLOS Medicine: published April 24, 2007 | https://doi.org/10.1371/journal.pmed.0040161

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XDR-TB in South Africa: Detention Is Not the Priority

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Adherence to TB Treatment in Ethiopia: Why Do Patients Default?

Hundie Tesfaye

PLOS Medicine: published April 24, 2007 | https://doi.org/10.1371/journal.pmed.0040165

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Why Most Published Research Findings Are False: Problems in the Analysis

Steven Goodman, Sander Greenland

PLOS Medicine: published April 24, 2007 | https://doi.org/10.1371/journal.pmed.0040168

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PLoS Medicine and Publication Ethics: When Is It Research?

Mary Ann Baily

PLOS Medicine: published April 24, 2007 | https://doi.org/10.1371/journal.pmed.0040169

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XDR-TB in South Africa: Back to TB Sanatoria Perhaps?

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PLOS Medicine: published April 24, 2007 | https://doi.org/10.1371/journal.pmed.0040160

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XDR-TB in South Africa: Theory and Practice

Jason Andrews, Sanjay Basu, David Scales, Duncan Smith-Rohrberg Maru, Ramnath Subbaraman

PLOS Medicine: published April 24, 2007 | https://doi.org/10.1371/journal.pmed.0040163

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Palladin Mutation Causes Familial Pancreatic Cancer: Absence in European Families

Emily Slater, Vera Amrillaeva, Volker Fendrich, Detlef Bartsch, Julie Earl, Louis J Vitone, John P Neoptolemos, William Greenhalf

PLOS Medicine: published April 24, 2007 | https://doi.org/10.1371/journal.pmed.0040164

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Training of Peer Reviewers: Validation of a 5-Point Rating Scale

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PLOS Medicine: published April 24, 2007 | https://doi.org/10.1371/journal.pmed.0040166

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