Characterization of Novel Antimalarial Compound ACT-451840: Preclinical Assessment of Activity and Dose–Efficacy Modeling

• Amélie Le Bihan,

  Affiliation Actelion Pharmaceuticals Ltd, Allschwil, Switzerland

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• Ruben de Kanter,

  Affiliation Actelion Pharmaceuticals Ltd, Allschwil, Switzerland

  http://orcid.org/0000-0001-7503-9776

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• Iñigo Angulo-Barturen,

  Affiliation GlaxoSmithKline, TresCantos Medicines Development Campus, Diseases of the Developing World, Tres Cantos, Madrid, Spain

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• Christoph Binkert,

  Affiliation Actelion Pharmaceuticals Ltd, Allschwil, Switzerland

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• Christoph Boss,

  Affiliation Actelion Pharmaceuticals Ltd, Allschwil, Switzerland

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• Reto Brun,

  Affiliations Swiss Tropical and Public Health Institute, Basel, Switzerland, University of Basel, Basel, Switzerland

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• Ralf Brunner,

  Affiliations Actelion Pharmaceuticals Ltd, Allschwil, Switzerland, Swiss Tropical and Public Health Institute, Basel, Switzerland, University of Basel, Basel, Switzerland

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• Stephan Buchmann,

  Affiliation Actelion Pharmaceuticals Ltd, Allschwil, Switzerland

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• Jeremy Burrows,

  Affiliation Medicines for Malaria Venture, Geneva, Switzerland

  http://orcid.org/0000-0001-8448-6068

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• Koen J. Dechering,

  Affiliation TropIQ Health Sciences B.V., Nijmegen, The Netherlands

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• Michael Delves,

  Affiliation Department of Life Sciences, Imperial College London, SW7 2AZ, London, United Kingdom

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• Sonja Ewerling,

  Affiliation Actelion Pharmaceuticals Ltd, Allschwil, Switzerland

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• Santiago Ferrer,

  Affiliation GlaxoSmithKline, TresCantos Medicines Development Campus, Diseases of the Developing World, Tres Cantos, Madrid, Spain

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• Christoph Fischli,

  Affiliations Swiss Tropical and Public Health Institute, Basel, Switzerland, University of Basel, Basel, Switzerland

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• Francisco Javier Gamo–Benito,

  Affiliation GlaxoSmithKline, TresCantos Medicines Development Campus, Diseases of the Developing World, Tres Cantos, Madrid, Spain

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• Nina F. Gnädig,

  Affiliation Department of Microbiology and Immunology, Columbia University Medical Center, New York, New York, United States of America

  http://orcid.org/0000-0002-8104-7032

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• Bibia Heidmann,

  Affiliation Actelion Pharmaceuticals Ltd, Allschwil, Switzerland

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• María Belén Jiménez-Díaz,

  Affiliation GlaxoSmithKline, TresCantos Medicines Development Campus, Diseases of the Developing World, Tres Cantos, Madrid, Spain

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• Didier Leroy,

  Affiliation Medicines for Malaria Venture, Geneva, Switzerland

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• Maria Santos Martínez,

  Affiliation GlaxoSmithKline, TresCantos Medicines Development Campus, Diseases of the Developing World, Tres Cantos, Madrid, Spain

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• Solange Meyer,

  Affiliation Actelion Pharmaceuticals Ltd, Allschwil, Switzerland

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• Joerg J. Moehrle,

  Affiliation Medicines for Malaria Venture, Geneva, Switzerland

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• Caroline L. Ng,

  Affiliation Department of Microbiology and Immunology, Columbia University Medical Center, New York, New York, United States of America

  http://orcid.org/0000-0001-8267-8453

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• Rintis Noviyanti,

  Affiliation Eijkman Institute for Molecular Biology, Jakarta, Indonesia

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• Andrea Ruecker,

  Affiliation Department of Life Sciences, Imperial College London, SW7 2AZ, London, United Kingdom

  http://orcid.org/0000-0003-3804-9670

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• Laura María Sanz,

  Affiliation GlaxoSmithKline, TresCantos Medicines Development Campus, Diseases of the Developing World, Tres Cantos, Madrid, Spain

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• Robert W. Sauerwein,

  Affiliation TropIQ Health Sciences B.V., Nijmegen, The Netherlands

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• Christian Scheurer,

  Affiliations Swiss Tropical and Public Health Institute, Basel, Switzerland, University of Basel, Basel, Switzerland

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• Sarah Schleiferboeck,

  Affiliations Swiss Tropical and Public Health Institute, Basel, Switzerland, University of Basel, Basel, Switzerland

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• Robert Sinden,

  Affiliation Department of Life Sciences, Imperial College London, SW7 2AZ, London, United Kingdom

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• Christopher Snyder,

  Affiliation Actelion Pharmaceuticals Ltd, Allschwil, Switzerland

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• Judith Straimer,

  Affiliation Department of Microbiology and Immunology, Columbia University Medical Center, New York, New York, United States of America

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• Grennady Wirjanata,

  Affiliation Global and Tropical Health Division, Menzies School of Health Research and Charles Darwin University, Darwin, Australia

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• Jutta Marfurt,

  Affiliation Global and Tropical Health Division, Menzies School of Health Research and Charles Darwin University, Darwin, Australia

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• Ric N. Price,

  Affiliations Global and Tropical Health Division, Menzies School of Health Research and Charles Darwin University, Darwin, Australia, Centre for Tropical Medicine and Global Health, Nuffield Department of Clinical Medicine, University of Oxford, Oxford, United Kingdom

  http://orcid.org/0000-0003-2000-2874

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• Thomas Weller,

  Affiliation Actelion Pharmaceuticals Ltd, Allschwil, Switzerland

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• Walter Fischli,

  Affiliation Actelion Pharmaceuticals Ltd, Allschwil, Switzerland

  http://orcid.org/0000-0002-6816-834X

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• David A. Fidock,

  Affiliations Department of Microbiology and Immunology, Columbia University Medical Center, New York, New York, United States of America, Division of Infectious Diseases, Department of Medicine, Columbia University Medical Center, New York, New York, United States of America

  http://orcid.org/0000-0001-6753-8938

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• Martine Clozel,

  Affiliation Actelion Pharmaceuticals Ltd, Allschwil, Switzerland

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•  [ ... ],
• Sergio Wittlin

  * E-mail: sergio.wittlin@unibas.ch

  Affiliations Swiss Tropical and Public Health Institute, Basel, Switzerland, University of Basel, Basel, Switzerland

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