About the Authors

Amélie Le Bihan

Affiliation Actelion Pharmaceuticals Ltd, Allschwil, Switzerland

Ruben de Kanter

Affiliation Actelion Pharmaceuticals Ltd, Allschwil, Switzerland

Iñigo Angulo-Barturen

Affiliation GlaxoSmithKline, TresCantos Medicines Development Campus, Diseases of the Developing World, Tres Cantos, Madrid, Spain

Christoph Binkert

Affiliation Actelion Pharmaceuticals Ltd, Allschwil, Switzerland

Christoph Boss

Affiliation Actelion Pharmaceuticals Ltd, Allschwil, Switzerland

Reto Brun

Affiliations Swiss Tropical and Public Health Institute, Basel, Switzerland, University of Basel, Basel, Switzerland

Ralf Brunner

Affiliations Actelion Pharmaceuticals Ltd, Allschwil, Switzerland, Swiss Tropical and Public Health Institute, Basel, Switzerland, University of Basel, Basel, Switzerland

Stephan Buchmann

Affiliation Actelion Pharmaceuticals Ltd, Allschwil, Switzerland

Jeremy Burrows

Affiliation Medicines for Malaria Venture, Geneva, Switzerland

Koen J. Dechering

Affiliation TropIQ Health Sciences B.V., Nijmegen, The Netherlands

Michael Delves

Affiliation Department of Life Sciences, Imperial College London, SW7 2AZ, London, United Kingdom

Sonja Ewerling

Affiliation Actelion Pharmaceuticals Ltd, Allschwil, Switzerland

Santiago Ferrer

Affiliation GlaxoSmithKline, TresCantos Medicines Development Campus, Diseases of the Developing World, Tres Cantos, Madrid, Spain

Christoph Fischli

Affiliations Swiss Tropical and Public Health Institute, Basel, Switzerland, University of Basel, Basel, Switzerland

Francisco Javier Gamo–Benito

Affiliation GlaxoSmithKline, TresCantos Medicines Development Campus, Diseases of the Developing World, Tres Cantos, Madrid, Spain

Nina F. Gnädig

Affiliation Department of Microbiology and Immunology, Columbia University Medical Center, New York, New York, United States of America

Bibia Heidmann

Affiliation Actelion Pharmaceuticals Ltd, Allschwil, Switzerland

María Belén Jiménez-Díaz

Affiliation GlaxoSmithKline, TresCantos Medicines Development Campus, Diseases of the Developing World, Tres Cantos, Madrid, Spain

Didier Leroy

Affiliation Medicines for Malaria Venture, Geneva, Switzerland

Maria Santos Martínez

Affiliation GlaxoSmithKline, TresCantos Medicines Development Campus, Diseases of the Developing World, Tres Cantos, Madrid, Spain

Solange Meyer

Affiliation Actelion Pharmaceuticals Ltd, Allschwil, Switzerland

Joerg J. Moehrle

Affiliation Medicines for Malaria Venture, Geneva, Switzerland

Caroline L. Ng

Affiliation Department of Microbiology and Immunology, Columbia University Medical Center, New York, New York, United States of America

Rintis Noviyanti

Affiliation Eijkman Institute for Molecular Biology, Jakarta, Indonesia

Andrea Ruecker

Affiliation Department of Life Sciences, Imperial College London, SW7 2AZ, London, United Kingdom

Laura María Sanz

Affiliation GlaxoSmithKline, TresCantos Medicines Development Campus, Diseases of the Developing World, Tres Cantos, Madrid, Spain

Robert W. Sauerwein

Affiliation TropIQ Health Sciences B.V., Nijmegen, The Netherlands

Christian Scheurer

Affiliations Swiss Tropical and Public Health Institute, Basel, Switzerland, University of Basel, Basel, Switzerland

Sarah Schleiferboeck

Affiliations Swiss Tropical and Public Health Institute, Basel, Switzerland, University of Basel, Basel, Switzerland

Robert Sinden

Affiliation Department of Life Sciences, Imperial College London, SW7 2AZ, London, United Kingdom

Christopher Snyder

Affiliation Actelion Pharmaceuticals Ltd, Allschwil, Switzerland

Judith Straimer

Affiliation Department of Microbiology and Immunology, Columbia University Medical Center, New York, New York, United States of America

Grennady Wirjanata

Affiliation Global and Tropical Health Division, Menzies School of Health Research and Charles Darwin University, Darwin, Australia

Jutta Marfurt

Affiliation Global and Tropical Health Division, Menzies School of Health Research and Charles Darwin University, Darwin, Australia

Ric N. Price

Affiliations Global and Tropical Health Division, Menzies School of Health Research and Charles Darwin University, Darwin, Australia, Centre for Tropical Medicine and Global Health, Nuffield Department of Clinical Medicine, University of Oxford, Oxford, United Kingdom

Thomas Weller

Affiliation Actelion Pharmaceuticals Ltd, Allschwil, Switzerland

Walter Fischli

Affiliation Actelion Pharmaceuticals Ltd, Allschwil, Switzerland

David A. Fidock

Affiliations Department of Microbiology and Immunology, Columbia University Medical Center, New York, New York, United States of America, Division of Infectious Diseases, Department of Medicine, Columbia University Medical Center, New York, New York, United States of America

Martine Clozel

Affiliation Actelion Pharmaceuticals Ltd, Allschwil, Switzerland

Sergio Wittlin

sergio.wittlin@unibas.ch

Affiliations Swiss Tropical and Public Health Institute, Basel, Switzerland, University of Basel, Basel, Switzerland

Competing Interests

I have read the journal's policy and the following authors of this manuscript have the following competing interests: KJD holds stocks in TropIQ Health Sciences. IAB, SF, FJGB, MBJD, MSM, LMS were employed by and owned shares of GlaxoSmithKline while conducting the studies presented. ALB, RDK, CBi, CBo, RaB, SB, SE, BH, SM, CSn,TW, WF, MC were employed by and owned shares of Actelion Pharmaceuticals Ltd while conducting the studies presented.

Author Contributions

Conceptualization: ALB RDK IAB CBi CBo ReB RaB SB JB KJD MD SE SF CF FJGB BH MBJD DL JM MSM SM JJM RN RNP AR LMS RWS CSc SS RS CSn GW TW WF MC SW NFG CLN JS DAF. Data curation: ALB RDK IAB CBi CBo ReB RaB SB JB KJD MD SE SF CF FJGB BH MBJD DL JM MSM SM JJM RN RNP AR LMS RWS CSc SS RS CSn GW TW WF MC SW NFG CLN JS DAF. Formal analysis: ALB RDK IAB CBi CBo ReB RaB SB JB KJD MD SE SF CF FJGB BH MBJD DL JMa MSM SM JJM RN RNP AR LMS RWS CSc SS RS CSn GW TW WF MC SW NFG CLN JS DAF. Funding acquisition: ALB CBi CBo ReB JB DL JJM WF DAF MC SW. Investigation: ALB RDK IAB CBi CBo ReB RaB SB JB KJD MD SE SF CF FJGB BH MBJD DL JM MSM SM JJM RN RNP AR LMS RWS CSc SS RS CSn GW TW WF MC SW NFG CLN JS DAF. Methodology: ALB RDK IAB CBi CBo ReB RaB SB JB KJD MD SE SF CF FJGB BH MBJD DL JM MSM SM JJM RN RNP AR LMS RWS CSc SS RS CSn GW TW WF MC SW NFG CLN JS DAF. Project administration: ALB. Resources: ALB RDK IAB CBi CBo ReB RaB SB JB KJD MD SE SF CF FJGB BH MBJD DL JM MSM SM JJM RN RNP AR LMS RWS CSc SS RS CSn GW TW WF MC SW NFG CLN JS DAF. Supervision: ALB RDK IAB CBi CBo ReB RaB SB JB KJD MD SE SF CF FJGB BH MBJD DL JM MSM SM JJM RN RNP AR LMS RWS CSc SS RS CSn GW TW WF MC SW NFG CLN JS DAF. Validation: ALB RDK IAB CBi CBo ReB RaB SB JB KJD MD SE SF CF FJGB BH MBJD DL JM MSM SM JJM RN RNP AR LMS RWS CSc SS RS CSn GW TW WF MC SW NFG CLN JS DAF. Visualization: ALB SW. Writing – original draft: ALB SW. Writing – review & editing: ALB RDK IAB CBi CBo ReB RaB SB JB KJD MD SE SF CF FJGB BH MBJD DL JM MSM SM JJM RN RNP AR LMS RWS CSc SS RS CSn GW TW WF MC SW NFG CLN JS DAF.