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November 2022

Example of an assembly path modulated by soft disorder found in the PDB [3d09_A (unbound), 5bua_A (1 partner), 2ady_A (2 partners), 5lgy_A (3 partners)]. We show several protein complexes in which a particular protein (whose structure is shown in black) progressively interacts with an increasing number of partners. We observe that the location of soft disordered regions (in orange) in simpler complexes contains information about where the new interfaces will be located after binding. Seoane et al 2022

Image Credit: B. Seoane and A. Carbone.

Editorials

Ten simple rules to cultivate belonging in collaborative data science research teams

Kaitlyn M. Gaynor, Therese Azevedo, Clarissa Boyajian, Julien Brun, Amber E. Budden, Allie Cole, Samantha Csik, Joe DeCesaro, Halina Do-Linh, Joan Dudney, Carmen Galaz García, Scout Leonard, Nicholas J. Lyon, Althea Marks, Julia Parish, Alexandra A. Phillips, Courtney Scarborough, Joshua Smith, Marcus Thompson, Camila Vargas Poulsen, Caitlin R. Fong

Ten simple rules for running a summer research program

Joseph C. Ayoob, Juan S. Ramírez-Lugo

Education Articles

Ten simple rules for developing visualization tools in genomics

Eloi Durant, Mathieu Rouard, Eric W. Ganko, Cedric Muller, Alan M. Cleary, Andrew D. Farmer, Matthieu Conte, Francois Sabot

Reproducibility efforts as a teaching tool: A pilot study

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Ten simple rules for funding scientific open source software

Carly Strasser, Kate Hertweck, Josh Greenberg, Dario Taraborelli, Elizabeth Vu

Topic Pages

Phylogenetic reconciliation

Hugo Menet, Vincent Daubin, Eric Tannier

Molecular source attribution

Elisa Chao, Connor Chato, Reid Vender, Abayomi S. Olabode, Roux-Cil Ferreira, Art F. Y. Poon

Research Articles

How public can public goods be? Environmental context shapes the evolutionary ecology of partially private goods

Brian A. Lerch, Derek A. Smith, Thomas Koffel, Sarah C. Bagby, Karen C. Abbott

Strength-dependent perturbation of whole-brain model working in different regimes reveals the role of fluctuations in brain dynamics

Yonatan Sanz Perl, Anira Escrichs, Enzo Tagliazucchi, Morten L. Kringelbach, Gustavo Deco

Training diversity promotes absolute-value-guided choice

Levi Solomyak, Paul B. Sharp, Eran Eldar

Inferring parameters of cancer evolution in chronic lymphocytic leukemia

Nathan D. Lee, Ivana Bozic

Probabilistic program inference in network-based epidemiological simulations

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Network topology metrics explaining enrichment of hybrid epithelial/mesenchymal phenotypes in metastasis

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A structural dynamics model for how CPEB3 binding to SUMO2 can regulate translational control in dendritic spines

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OrganoID: A versatile deep learning platform for tracking and analysis of single-organoid dynamics

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AvP: A software package for automatic phylogenetic detection of candidate horizontal gene transfers

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Protein prediction models support widespread post-transcriptional regulation of protein abundance by interacting partners

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BIPS—A code base for designing and coding of a Phage ImmunoPrecipitation Oligo Library

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Adaptive multi-objective control explains how humans make lateral maneuvers while walking

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SyBLaRS: A web service for laying out, rendering and mining biological maps in SBGN, SBML and more

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Dosing time optimization of antihypertensive medications by including the circadian rhythm in pharmacokinetic-pharmacodynamic models

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Brain connectivity meets reservoir computing

Fabrizio Damicelli, Claus C. Hilgetag, Alexandros Goulas

Computationally efficient mechanism discovery for cell invasion with uncertainty quantification

Daniel J. VandenHeuvel, Christopher Drovandi, Matthew J. Simpson

A neurocomputational theory of action regulation predicts motor behavior in neurotypical individuals and patients with Parkinson’s disease

Shan Zhong, Jeong Woo Choi, Nadia G. Hashoush, Diana Babayan, Mahsa Malekmohammadi, Nader Pouratian, Vassilios Christopoulos

Soft disorder modulates the assembly path of protein complexes

Beatriz Seoane, Alessandra Carbone

Inferring a spatial code of cell-cell interactions across a whole animal body

Erick Armingol, Abbas Ghaddar, Chintan J. Joshi, Hratch Baghdassarian, Isaac Shamie, Jason Chan, Hsuan-Lin Her, Samuel Berhanu, Anushka Dar, Fabiola Rodriguez-Armstrong, Olivia Yang, Eyleen J. O’Rourke, Nathan E. Lewis

Sleep prevents catastrophic forgetting in spiking neural networks by forming a joint synaptic weight representation

Ryan Golden, Jean Erik Delanois, Pavel Sanda, Maxim Bazhenov

Operant conditioning of stochastic chemical reaction networks

David Arredondo, Matthew R. Lakin

HELIOS: High-speed sequence alignment in optics

Ehsan Maleki, Saeedeh Akbari Rokn Abadi, Somayyeh Koohi

Amino acid variants of SARS-CoV-2 papain-like protease have impact on drug binding

Agata P. Perlinska, Adam Stasiulewicz, Mai Lan Nguyen, Karolina Swiderska, Mikolaj Zmudzinski, Alicja W. Maksymiuk, Marcin Drag, Joanna I. Sulkowska

Coupling and heterogeneity modulate pacemaking capability in healthy and diseased two-dimensional sinoatrial node tissue models

Chiara Campana, Eugenio Ricci, Chiara Bartolucci, Stefano Severi, Eric A. Sobie

Deep reinforcement learning for optimal experimental design in biology

Neythen J. Treloar, Nathan Braniff, Brian Ingalls, Chris P. Barnes

Social dilemmas of sociality due to beneficial and costly contagion

Daniel B. Cooney, Dylan H. Morris, Simon A. Levin, Daniel I. Rubenstein, Pawel Romanczuk

Look twice: A generalist computational model predicts return fixations across tasks and species

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Effective resistance against pandemics: Mobility network sparsification for high-fidelity epidemic simulations

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Interpreting and de-noising genetically engineered barcodes in a DNA virus

Sylvain Blois, Benjamin M. Goetz, James J. Bull, Christopher S. Sullivan

Exploring the mono-/bistability range of positively autoregulated signaling systems in the presence of competing transcription factor binding sites

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Trends in SARS-CoV-2 infection prevalence during England’s roadmap out of lockdown, January to July 2021

Oliver Eales, Haowei Wang, David Haw, Kylie E. C. Ainslie, Caroline E. Walters, Christina Atchison, Graham Cooke, Wendy Barclay, Helen Ward, Ara Darzi, Deborah Ashby, Christl A. Donnelly, Paul Elliott, Steven Riley

Role of path information in visual perception of joint stiffness

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The geometry of representational drift in natural and artificial neural networks

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Experimental validation of computerised models of clustering of platelet glycoprotein receptors that signal via tandem SH2 domain proteins

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Inference of B cell clonal families using heavy/light chain pairing information

Duncan K. Ralph, Frederick A. Matsen IV

Efficient inference and identifiability analysis for differential equation models with random parameters

Alexander P. Browning, Christopher Drovandi, Ian W. Turner, Adrianne L. Jenner, Matthew J. Simpson

Sampling effects and measurement overlap can bias the inference of neuronal avalanches

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Optimized phylogenetic clustering of HIV-1 sequence data for public health applications

Connor Chato, Yi Feng, Yuhua Ruan, Hui Xing, Joshua Herbeck, Marcia Kalish, Art F. Y. Poon

Modelling the synergistic effect of bacteriophage and antibiotics on bacteria: Killers and drivers of resistance evolution

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Cluster detection with random neighbourhood covering: Application to invasive Group A Streptococcal disease

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Corrections

Correction: All2: A tool for selecting mosaic mutations from comprehensive multi-cell comparisons

Vivekananda Sarangi, Yeongjun Jang, Milovan Suvakov, Taejeong Bae, Liana Fasching, Shobana Sekar, Livia Tomasini, Jessica Mariani, Flora M. Vaccarino, Alexej Abyzov

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