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Table of Contents

June 2021

The image shows three microseconds from the life time of a nucleosome. Snapshots in time were taken every 4 nanoseconds and were superimposed on the core region of the histones (white). The positions of the DNA and the flexible histone tails in all snapshots are shown. The DNA is in yellow and the histone tails in blue (histone H3), green (histone H4), orange (histone H2A, N-terminal), red (histone H2A, C-terminal), cyan (histone H2B). Huertas et al 2021

Image Credit: Jan Huertas and Vlad Cojocaru, ©MPI Münster, ©Hubrecht Institute

Editorials

Ten simple rules for designing analogue science games

Sam Illingworth, Paul Wake

Ten simple rules for acing virtual interviews

Dalen Chan, Christina M. Fitzsimmons, Mariana D. Mandler, Pedro J. Batista

Education

Experiences and lessons learned from two virtual, hands-on microbiome bioinformatics workshops

Matthew R. Dillon, Evan Bolyen, Anja Adamov, Aeriel Belk, Emily Borsom, Zachary Burcham, Justine W. Debelius, Heather Deel, Alex Emmons, Mehrbod Estaki, Chloe Herman, Christopher R. Keefe, Jamie T. Morton, Renato R. M. Oliveira, Andrew Sanchez, Anthony Simard, Yoshiki Vázquez-Baeza, Michal Ziemski, Hazuki E. Miwa, Terry A. Kerere, Carline Coote, Richard Bonneau, Rob Knight, Guilherme Oliveira, Piraveen Gopalasingam, Benjamin D. Kaehler, Emily K. Cope, Jessica L. Metcalf, Michael S. Robeson II, Nicholas A. Bokulich, J. Gregory Caporaso

Perspective

Ten simple rules for doing a postdoc in pharma

Jitao David Zhang

Review

Reflecting on 20 years of breast cancer modeling in CISNET: Recommendations for future cancer systems modeling efforts

Amy Trentham-Dietz, Oguzhan Alagoz, Christina Chapman, Xuelin Huang, Jinani Jayasekera, Nicolien T. van Ravesteyn, Sandra J. Lee, Clyde B. Schechter, Jennifer M. Yeh, Sylvia K. Plevritis, Jeanne S. Mandelblatt, for the Breast Working Group of the Cancer Intervention and Surveillance Modeling Network (CISNET)

Research Articles

Computation of condition-dependent proteome allocation reveals variability in the macro and micro nutrient requirements for growth

Colton J. Lloyd, Jonathan Monk, Laurence Yang, Ali Ebrahim, Bernhard O. Palsson

pyTFM: A tool for traction force and monolayer stress microscopy

Andreas Bauer, Magdalena Prechová, Lena Fischer, Ingo Thievessen, Martin Gregor, Ben Fabry

Similar sensorimotor transformations control balance during standing and walking

Maarten Afschrift, Friedl De Groote, Ilse Jonkers

Numerical evaluation reveals the effect of branching morphology on vessel transport properties during angiogenesis

Fatemeh Mirzapour-Shafiyi, Yukinori Kametani, Takao Hikita, Yosuke Hasegawa, Masanori Nakayama

Bivalent chromatin as a therapeutic target in cancer: An in silico predictive approach for combining epigenetic drugs

Tomás Alarcón, Josep Sardanyés, Antoni Guillamon, Javier A. Menendez

Iliski, a software for robust calculation of transfer functions

Ali-Kemal Aydin, William D. Haselden, Julie Dang, Patrick J. Drew, Serge Charpak, Davide Boido

High-affinity P2Y2 and low-affinity P2X7 receptor interaction modulates ATP-mediated calcium signaling in murine osteoblasts

Nicholas Mikolajewicz, Delaney Smith, Svetlana V. Komarova, Anmar Khadra

Embedding optimization reveals long-lasting history dependence in neural spiking activity

Lucas Rudelt, Daniel González Marx, Michael Wibral, Viola Priesemann

Efficient representations of tumor diversity with paired DNA-RNA aberrations

Qian Ke, Wikum Dinalankara, Laurent Younes, Donald Geman, Luigi Marchionni

netgsa: Fast computation and interactive visualization for topology-based pathway enrichment analysis

Michael Hellstern, Jing Ma, Kun Yue, Ali Shojaie

An image-computable model of human visual shape similarity

Yaniv Morgenstern, Frieder Hartmann, Filipp Schmidt, Henning Tiedemann, Eugen Prokott, Guido Maiello, Roland W. Fleming

Estimating the cumulative incidence of COVID-19 in the United States using influenza surveillance, virologic testing, and mortality data: Four complementary approaches

Fred S. Lu, Andre T. Nguyen, Nicholas B. Link, Mathieu Molina, Jessica T. Davis, Matteo Chinazzi, Xinyue Xiong, Alessandro Vespignani, Marc Lipsitch, Mauricio Santillana

Growth rules for the repair of Asynchronous Irregular neuronal networks after peripheral lesions

Ankur Sinha, Christoph Metzner, Neil Davey, Roderick Adams, Michael Schmuker, Volker Steuber

Estimation of country-level incidence of early-onset invasive Group B Streptococcus disease in infants using Bayesian methods

Bronner P. Gonçalves, Simon R. Procter, Sam Clifford, Artemis Koukounari, Proma Paul, Alexandra Lewin, Mark Jit, Joy Lawn

A new phylodynamic model of Mycobacterium bovis transmission in a multi-host system uncovers the role of the unobserved reservoir

Anthony O’Hare, Daniel Balaz, David M. Wright, Carl McCormick, Stanley McDowell, Hannah Trewby, Robin A. Skuce, Rowland R. Kao

Histone tails cooperate to control the breathing of genomic nucleosomes

Jan Huertas, Hans Robert Schöler, Vlad Cojocaru

Galaxy-ML: An accessible, reproducible, and scalable machine learning toolkit for biomedicine

Qiang Gu, Anup Kumar, Simon Bray, Allison Creason, Alireza Khanteymoori, Vahid Jalili, Björn Grüning, Jeremy Goecks

The functional role of sequentially neuromodulated synaptic plasticity in behavioural learning

Grace Wan Yu Ang, Clara S. Tang, Y. Audrey Hay, Sara Zannone, Ole Paulsen, Claudia Clopath

Ion dynamics at the energy-deprived tripartite synapse

Manu Kalia, Hil G. E. Meijer, Stephan A. van Gils, Michel J. A. M. van Putten, Christine R. Rose

Inclusion of maintenance energy improves the intracellular flux predictions of CHO

Diana Széliová, Jerneja Štor, Isabella Thiel, Marcus Weinguny, Michael Hanscho, Gabriele Lhota, Nicole Borth, Jürgen Zanghellini, David E. Ruckerbauer, Isabel Rocha

Learning divisive normalization in primary visual cortex

Max F. Burg, Santiago A. Cadena, George H. Denfield, Edgar Y. Walker, Andreas S. Tolias, Matthias Bethge, Alexander S. Ecker

Mechanistic basis of post-treatment control of SIV after anti-α4β7 antibody therapy

Chad R. Wells, Youfang Cao, David P. Durham, Siddappa N. Byrareddy, Aftab A. Ansari, Nancy H. Ruddle, Jeffrey P. Townsend, Alison P. Galvani, Alan S. Perelson

Quantifying cell transitions in C. elegans with data-fitted landscape models

Elena Camacho-Aguilar, Aryeh Warmflash, David A. Rand

Unsupervised logic-based mechanism inference for network-driven biological processes

Martina Prugger, Lukas Einkemmer, Samantha P. Beik, Perry T. Wasdin, Leonard A. Harris, Carlos F. Lopez

Ten simple rules for making a vocabulary FAIR

Simon J. D. Cox, Alejandra N. Gonzalez-Beltran, Barbara Magagna, Maria-Cristina Marinescu

Three-dimensional topology optimization model to simulate the external shapes of bone

Misaki Sakashita, Shintaro Yamasaki, Kentaro Yaji, Atsushi Kawamoto, Shigeru Kondo

TSCCA: A tensor sparse CCA method for detecting microRNA-gene patterns from multiple cancers

Wenwen Min, Tsung-Hui Chang, Shihua Zhang, Xiang Wan

Thalamo-cortical spiking model of incremental learning combining perception, context and NREM-sleep

Bruno Golosio, Chiara De Luca, Cristiano Capone, Elena Pastorelli, Giovanni Stegel, Gianmarco Tiddia, Giulia De Bonis, Pier Stanislao Paolucci

The visual cortex produces gamma band echo in response to broadband visual flicker

Alexander Zhigalov, Katharina Duecker, Ole Jensen

Stochastic optimal feedforward-feedback control determines timing and variability of arm movements with or without vision

Bastien Berret, Adrien Conessa, Nicolas Schweighofer, Etienne Burdet

GCSENet: A GCN, CNN and SENet ensemble model for microRNA-disease association prediction

Zhong Li, Kaiyancheng Jiang, Shengwei Qin, Yijun Zhong, Arne Elofsson

Modeling influenza seasonality in the tropics and subtropics

Haokun Yuan, Sarah C. Kramer, Eric H. Y. Lau, Benjamin J. Cowling, Wan Yang

Efficient encoding of spectrotemporal information for bat echolocation

Adarsh Chitradurga Achutha, Herbert Peremans, Uwe Firzlaff, Dieter Vanderelst

A physicochemical model of odor sampling

Mitchell E. Gronowitz, Adam Liu, Qiang Qiu, C. Ron Yu, Thomas A. Cleland

A network modelling approach to assess non-pharmaceutical disease controls in a worker population: An application to SARS-CoV-2

Edward M. Hill, Benjamin D. Atkins, Matt J. Keeling, Louise Dyson, Michael J. Tildesley

BIO-LGCA: A cellular automaton modelling class for analysing collective cell migration

Andreas Deutsch, Josué Manik Nava-Sedeño, Simon Syga, Haralampos Hatzikirou

How does feedback from phage infections influence the evolution of phase variation in Campylobacter?

Simran K. Sandhu, Christopher D. Bayliss, Andrew Yu. Morozov

PHENSIM: Phenotype Simulator

Salvatore Alaimo, Rosaria Valentina Rapicavoli, Gioacchino P. Marceca, Alessandro La Ferlita, Oksana B. Serebrennikova, Philip N. Tsichlis, Bud Mishra, Alfredo Pulvirenti, Alfredo Ferro

Novelty is not surprise: Human exploratory and adaptive behavior in sequential decision-making

He A. Xu, Alireza Modirshanechi, Marco P. Lehmann, Wulfram Gerstner, Michael H. Herzog

CytoPy: An autonomous cytometry analysis framework

Ross J. Burton, Raya Ahmed, Simone M. Cuff, Sarah Baker, Andreas Artemiou, Matthias Eberl

Examining the dynamics of Epstein-Barr virus shedding in the tonsils and the impact of HIV-1 coinfection on daily saliva viral loads

Catherine M. Byrne, Christine Johnston, Jackson Orem, Fred Okuku, Meei-Li Huang, Habibur Rahman, Anna Wald, Lawrence Corey, Joshua T. Schiffer, Corey Casper, Daniel Coombs, Soren Gantt

Optimizing mitochondrial maintenance in extended neuronal projections

Anamika Agrawal, Elena F. Koslover

Multiple morphogens and rapid elongation promote segmental patterning during development

Yuchi Qiu, Lianna Fung, Thomas F. Schilling, Qing Nie

lra: A long read aligner for sequences and contigs

Jingwen Ren, Mark J. P. Chaisson

Mechanism of collagen folding propagation studied by Molecular Dynamics simulations

Julian Hartmann, Martin Zacharias

Multiscale modeling of tumor growth and angiogenesis: Evaluation of tumor-targeted therapy

Sahar Jafari Nivlouei, M. Soltani, João Carvalho, Rui Travasso, Mohammad Reza Salimpour, Ebrahim Shirani

Mixture-of-Experts Variational Autoencoder for clustering and generating from similarity-based representations on single cell data

Andreas Kopf, Vincent Fortuin, Vignesh Ram Somnath, Manfred Claassen

A zero inflated log-normal model for inference of sparse microbial association networks

Vincent Prost, Stéphane Gazut, Thomas Brüls

A549 in-silico 1.0: A first computational model to simulate cell cycle dependent ion current modulation in the human lung adenocarcinoma

Sonja Langthaler, Theresa Rienmüller, Susanne Scheruebel, Brigitte Pelzmann, Niroj Shrestha, Klaus Zorn-Pauly, Wolfgang Schreibmayer, Andrew Koff, Christian Baumgartner

Topological data analysis distinguishes parameter regimes in the Anderson-Chaplain model of angiogenesis

John T. Nardini, Bernadette J. Stolz, Kevin B. Flores, Heather A. Harrington, Helen M. Byrne

Identifying the combinatorial control of signal-dependent transcription factors

Ning Wang, Diane Lefaudeux, Anup Mazumder, Jingyi Jessica Li, Alexander Hoffmann

Agent-based modeling of the central amygdala and pain using cell-type specific physiological parameters

Rachael Miller Neilan, Gabrielle Majetic, Mauricio Gil-Silva, Anisha P. Adke, Yarimar Carrasquillo, Benedict J. Kolber

Methodology for rigorous modeling of protein conformational changes by Rosetta using DEER distance restraints

Diego del Alamo, Kevin L. Jagessar, Jens Meiler, Hassane S. Mchaourab

Mass spectrometry and machine learning for the accurate diagnosis of benzylpenicillin and multidrug resistance of Staphylococcus aureus in bovine mastitis

Necati Esener, Alexandre Maciel-Guerra, Katharina Giebel, Daniel Lea, Martin J. Green, Andrew J. Bradley, Tania Dottorini

De novo mutational signature discovery in tumor genomes using SparseSignatures

Avantika Lal, Keli Liu, Robert Tibshirani, Arend Sidow, Daniele Ramazzotti

Contact tracing efficiency, transmission heterogeneity, and accelerating COVID-19 epidemics

Billy J. Gardner, A. Marm Kilpatrick

Inhibition of RPS6K reveals context-dependent Akt activity in luminal breast cancer cells

Cemal Erdem, Adrian V. Lee, D. Lansing Taylor, Timothy R. Lezon

Multidimensional analysis and detection of informative features in human brain white matter

Adam Richie-Halford, Jason D. Yeatman, Noah Simon, Ariel Rokem

A computational model of pig ventricular cardiomyocyte electrophysiology and calcium handling: Translation from pig to human electrophysiology

Namit Gaur, Xiao-Yan Qi, David Benoist, Olivier Bernus, Ruben Coronel, Stanley Nattel, Edward J. Vigmond

Behavioral correlates of cortical semantic representations modeled by word vectors

Satoshi Nishida, Antoine Blanc, Naoya Maeda, Masataka Kado, Shinji Nishimoto

Regulating synchronous oscillations of cerebellar granule cells by different types of inhibition

Yuanhong Tang, Lingling An, Quan Wang, Jian K. Liu

Simulation of angiogenesis in three dimensions: Application to cerebral cortex

Jonathan P. Alberding, Timothy W. Secomb

Molecular signatures of silencing suppression degeneracy from a complex RNA virus

Silvia Ambrós, Neus Gómez-Muñoz, Silvia Giménez-Santamarina, Javier Sánchez-Vicente, Josep Navarro-López, Fernando Martínez, José-Antonio Daròs, Guillermo Rodrigo