The image shows three microseconds from the life time of a nucleosome. Snapshots in time were taken every 4 nanoseconds and were superimposed on the core region of the histones (white). The positions of the DNA and the flexible histone tails in all snapshots are shown. The DNA is in yellow and the histone tails in blue (histone H3), green (histone H4), orange (histone H2A, N-terminal), red (histone H2A, C-terminal), cyan (histone H2B). Huertas et al 2021
Image Credit: Jan Huertas and Vlad Cojocaru, ©MPI Münster, ©Hubrecht Institute
Editorials
Ten simple rules for designing analogue science games
PLOS Computational Biology: published June 10, 2021 | https://doi.org/10.1371/journal.pcbi.1009009
Ten simple rules for acing virtual interviews
PLOS Computational Biology: published June 24, 2021 | https://doi.org/10.1371/journal.pcbi.1009057
Education
Experiences and lessons learned from two virtual, hands-on microbiome bioinformatics workshops
PLOS Computational Biology: published June 24, 2021 | https://doi.org/10.1371/journal.pcbi.1009056
Perspective
Ten simple rules for doing a postdoc in pharma
PLOS Computational Biology: published June 3, 2021 | https://doi.org/10.1371/journal.pcbi.1008989
Review
Reflecting on 20 years of breast cancer modeling in CISNET: Recommendations for future cancer systems modeling efforts
PLOS Computational Biology: published June 17, 2021 | https://doi.org/10.1371/journal.pcbi.1009020
Research Articles
Computation of condition-dependent proteome allocation reveals variability in the macro and micro nutrient requirements for growth
PLOS Computational Biology: published June 23, 2021 | https://doi.org/10.1371/journal.pcbi.1007817
pyTFM: A tool for traction force and monolayer stress microscopy
PLOS Computational Biology: published June 21, 2021 | https://doi.org/10.1371/journal.pcbi.1008364
Similar sensorimotor transformations control balance during standing and walking
PLOS Computational Biology: published June 25, 2021 | https://doi.org/10.1371/journal.pcbi.1008369
Numerical evaluation reveals the effect of branching morphology on vessel transport properties during angiogenesis
PLOS Computational Biology: published June 16, 2021 | https://doi.org/10.1371/journal.pcbi.1008398
Bivalent chromatin as a therapeutic target in cancer: An in silico predictive approach for combining epigenetic drugs
PLOS Computational Biology: published June 21, 2021 | https://doi.org/10.1371/journal.pcbi.1008408
Paradoxical phase response of gamma rhythms facilitates their entrainment in heterogeneous networks
PLOS Computational Biology: published June 30, 2021 | https://doi.org/10.1371/journal.pcbi.1008575
Implications of diffusion and time-varying morphogen gradients for the dynamic positioning and precision of bistable gene expression boundaries
PLOS Computational Biology: published June 1, 2021 | https://doi.org/10.1371/journal.pcbi.1008589
Iliski, a software for robust calculation of transfer functions
PLOS Computational Biology: published June 14, 2021 | https://doi.org/10.1371/journal.pcbi.1008614
How public reaction to disease information across scales and the impacts of vector control methods influence disease prevalence and control efficacy
PLOS Computational Biology: published June 28, 2021 | https://doi.org/10.1371/journal.pcbi.1008762
High-affinity P2Y2 and low-affinity P2X7 receptor interaction modulates ATP-mediated calcium signaling in murine osteoblasts
PLOS Computational Biology: published June 21, 2021 | https://doi.org/10.1371/journal.pcbi.1008872
Embedding optimization reveals long-lasting history dependence in neural spiking activity
PLOS Computational Biology: published June 1, 2021 | https://doi.org/10.1371/journal.pcbi.1008927
Efficient representations of tumor diversity with paired DNA-RNA aberrations
PLOS Computational Biology: published June 11, 2021 | https://doi.org/10.1371/journal.pcbi.1008944
Categorical judgments do not modify sensory representations in working memory
PLOS Computational Biology: published June 1, 2021 | https://doi.org/10.1371/journal.pcbi.1008968
Analogous computations in working memory input, output and motor gating: Electrophysiological and computational modeling evidence
PLOS Computational Biology: published June 7, 2021 | https://doi.org/10.1371/journal.pcbi.1008971
netgsa: Fast computation and interactive visualization for topology-based pathway enrichment analysis
PLOS Computational Biology: published June 11, 2021 | https://doi.org/10.1371/journal.pcbi.1008979
An image-computable model of human visual shape similarity
PLOS Computational Biology: published June 1, 2021 | https://doi.org/10.1371/journal.pcbi.1008981
Estimating the cumulative incidence of COVID-19 in the United States using influenza surveillance, virologic testing, and mortality data: Four complementary approaches
PLOS Computational Biology: published June 17, 2021 | https://doi.org/10.1371/journal.pcbi.1008994
Growth rules for the repair of Asynchronous Irregular neuronal networks after peripheral lesions
PLOS Computational Biology: published June 1, 2021 | https://doi.org/10.1371/journal.pcbi.1008996
Estimation of country-level incidence of early-onset invasive Group B Streptococcus disease in infants using Bayesian methods
PLOS Computational Biology: published June 14, 2021 | https://doi.org/10.1371/journal.pcbi.1009001
A new phylodynamic model of Mycobacterium bovis transmission in a multi-host system uncovers the role of the unobserved reservoir
PLOS Computational Biology: published June 25, 2021 | https://doi.org/10.1371/journal.pcbi.1009005
Histone tails cooperate to control the breathing of genomic nucleosomes
PLOS Computational Biology: published June 3, 2021 | https://doi.org/10.1371/journal.pcbi.1009013
Galaxy-ML: An accessible, reproducible, and scalable machine learning toolkit for biomedicine
PLOS Computational Biology: published June 1, 2021 | https://doi.org/10.1371/journal.pcbi.1009014
The functional role of sequentially neuromodulated synaptic plasticity in behavioural learning
PLOS Computational Biology: published June 10, 2021 | https://doi.org/10.1371/journal.pcbi.1009017
Ion dynamics at the energy-deprived tripartite synapse
PLOS Computational Biology: published June 18, 2021 | https://doi.org/10.1371/journal.pcbi.1009019
Inclusion of maintenance energy improves the intracellular flux predictions of CHO
PLOS Computational Biology: published June 11, 2021 | https://doi.org/10.1371/journal.pcbi.1009022
Expectancy-based rhythmic entrainment as continuous Bayesian inference
PLOS Computational Biology: published June 9, 2021 | https://doi.org/10.1371/journal.pcbi.1009025
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Learning divisive normalization in primary visual cortex
PLOS Computational Biology: published June 7, 2021 | https://doi.org/10.1371/journal.pcbi.1009028
Mechanistic basis of post-treatment control of SIV after anti-α4β7 antibody therapy
PLOS Computational Biology: published June 9, 2021 | https://doi.org/10.1371/journal.pcbi.1009031
Quantifying cell transitions in C. elegans with data-fitted landscape models
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Unsupervised logic-based mechanism inference for network-driven biological processes
PLOS Computational Biology: published June 2, 2021 | https://doi.org/10.1371/journal.pcbi.1009035
Ten simple rules for making a vocabulary FAIR
PLOS Computational Biology: published June 16, 2021 | https://doi.org/10.1371/journal.pcbi.1009041
Three-dimensional topology optimization model to simulate the external shapes of bone
PLOS Computational Biology: published June 16, 2021 | https://doi.org/10.1371/journal.pcbi.1009043
TSCCA: A tensor sparse CCA method for detecting microRNA-gene patterns from multiple cancers
PLOS Computational Biology: published June 1, 2021 | https://doi.org/10.1371/journal.pcbi.1009044
Thalamo-cortical spiking model of incremental learning combining perception, context and NREM-sleep
PLOS Computational Biology: published June 28, 2021 | https://doi.org/10.1371/journal.pcbi.1009045
The visual cortex produces gamma band echo in response to broadband visual flicker
PLOS Computational Biology: published June 1, 2021 | https://doi.org/10.1371/journal.pcbi.1009046
Stochastic optimal feedforward-feedback control determines timing and variability of arm movements with or without vision
PLOS Computational Biology: published June 11, 2021 | https://doi.org/10.1371/journal.pcbi.1009047
GCSENet: A GCN, CNN and SENet ensemble model for microRNA-disease association prediction
PLOS Computational Biology: published June 3, 2021 | https://doi.org/10.1371/journal.pcbi.1009048
Effect of cellular rearrangement time delays on the rheology of vertex models for confluent tissues
PLOS Computational Biology: published June 7, 2021 | https://doi.org/10.1371/journal.pcbi.1009049
Modeling influenza seasonality in the tropics and subtropics
PLOS Computational Biology: published June 9, 2021 | https://doi.org/10.1371/journal.pcbi.1009050
Efficient encoding of spectrotemporal information for bat echolocation
PLOS Computational Biology: published June 28, 2021 | https://doi.org/10.1371/journal.pcbi.1009052
A physicochemical model of odor sampling
PLOS Computational Biology: published June 11, 2021 | https://doi.org/10.1371/journal.pcbi.1009054
A network modelling approach to assess non-pharmaceutical disease controls in a worker population: An application to SARS-CoV-2
PLOS Computational Biology: published June 16, 2021 | https://doi.org/10.1371/journal.pcbi.1009058
coupleCoC+: An information-theoretic co-clustering-based transfer learning framework for the integrative analysis of single-cell genomic data
PLOS Computational Biology: published June 2, 2021 | https://doi.org/10.1371/journal.pcbi.1009064
BIO-LGCA: A cellular automaton modelling class for analysing collective cell migration
PLOS Computational Biology: published June 15, 2021 | https://doi.org/10.1371/journal.pcbi.1009066
How does feedback from phage infections influence the evolution of phase variation in Campylobacter?
PLOS Computational Biology: published June 14, 2021 | https://doi.org/10.1371/journal.pcbi.1009067
Free energy landscape of RNA binding dynamics in start codon recognition by eukaryotic ribosomal pre-initiation complex
PLOS Computational Biology: published June 14, 2021 | https://doi.org/10.1371/journal.pcbi.1009068
PHENSIM: Phenotype Simulator
PLOS Computational Biology: published June 24, 2021 | https://doi.org/10.1371/journal.pcbi.1009069
Novelty is not surprise: Human exploratory and adaptive behavior in sequential decision-making
PLOS Computational Biology: published June 3, 2021 | https://doi.org/10.1371/journal.pcbi.1009070
CytoPy: An autonomous cytometry analysis framework
PLOS Computational Biology: published June 8, 2021 | https://doi.org/10.1371/journal.pcbi.1009071
Examining the dynamics of Epstein-Barr virus shedding in the tonsils and the impact of HIV-1 coinfection on daily saliva viral loads
PLOS Computational Biology: published June 21, 2021 | https://doi.org/10.1371/journal.pcbi.1009072
Optimizing mitochondrial maintenance in extended neuronal projections
PLOS Computational Biology: published June 9, 2021 | https://doi.org/10.1371/journal.pcbi.1009073
Multiple morphogens and rapid elongation promote segmental patterning during development
PLOS Computational Biology: published June 23, 2021 | https://doi.org/10.1371/journal.pcbi.1009077
lra: A long read aligner for sequences and contigs
PLOS Computational Biology: published June 21, 2021 | https://doi.org/10.1371/journal.pcbi.1009078
Mechanism of collagen folding propagation studied by Molecular Dynamics simulations
PLOS Computational Biology: published June 8, 2021 | https://doi.org/10.1371/journal.pcbi.1009079
Modeling the impact of single-cell stochasticity and size control on the population growth rate in asymmetrically dividing cells
PLOS Computational Biology: published June 21, 2021 | https://doi.org/10.1371/journal.pcbi.1009080
Multiscale modeling of tumor growth and angiogenesis: Evaluation of tumor-targeted therapy
PLOS Computational Biology: published June 23, 2021 | https://doi.org/10.1371/journal.pcbi.1009081
Analyzing cancer gene expression data through the lens of normal tissue-specificity
PLOS Computational Biology: published June 18, 2021 | https://doi.org/10.1371/journal.pcbi.1009085
Mixture-of-Experts Variational Autoencoder for clustering and generating from similarity-based representations on single cell data
PLOS Computational Biology: published June 30, 2021 | https://doi.org/10.1371/journal.pcbi.1009086
A zero inflated log-normal model for inference of sparse microbial association networks
PLOS Computational Biology: published June 18, 2021 | https://doi.org/10.1371/journal.pcbi.1009089
A549 in-silico 1.0: A first computational model to simulate cell cycle dependent ion current modulation in the human lung adenocarcinoma
PLOS Computational Biology: published June 22, 2021 | https://doi.org/10.1371/journal.pcbi.1009091
Designing microbial communities to maximize the thermodynamic driving force for the production of chemicals
PLOS Computational Biology: published June 15, 2021 | https://doi.org/10.1371/journal.pcbi.1009093
Topological data analysis distinguishes parameter regimes in the Anderson-Chaplain model of angiogenesis
PLOS Computational Biology: published June 28, 2021 | https://doi.org/10.1371/journal.pcbi.1009094
Identifying the combinatorial control of signal-dependent transcription factors
PLOS Computational Biology: published June 24, 2021 | https://doi.org/10.1371/journal.pcbi.1009095
Agent-based modeling of the central amygdala and pain using cell-type specific physiological parameters
PLOS Computational Biology: published June 8, 2021 | https://doi.org/10.1371/journal.pcbi.1009097
Methodology for rigorous modeling of protein conformational changes by Rosetta using DEER distance restraints
PLOS Computational Biology: published June 16, 2021 | https://doi.org/10.1371/journal.pcbi.1009107
Mass spectrometry and machine learning for the accurate diagnosis of benzylpenicillin and multidrug resistance of Staphylococcus aureus in bovine mastitis
PLOS Computational Biology: published June 11, 2021 | https://doi.org/10.1371/journal.pcbi.1009108
A computational grid-to-place-cell transformation model indicates a synaptic driver of place cell impairment in early-stage Alzheimer’s Disease
PLOS Computational Biology: published June 16, 2021 | https://doi.org/10.1371/journal.pcbi.1009115
SDImpute: A statistical block imputation method based on cell-level and gene-level information for dropouts in single-cell RNA-seq data
PLOS Computational Biology: published June 17, 2021 | https://doi.org/10.1371/journal.pcbi.1009118
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De novo mutational signature discovery in tumor genomes using SparseSignatures
PLOS Computational Biology: published June 28, 2021 | https://doi.org/10.1371/journal.pcbi.1009119
Contrasting factors associated with COVID-19-related ICU admission and death outcomes in hospitalised patients by means of Shapley values
PLOS Computational Biology: published June 23, 2021 | https://doi.org/10.1371/journal.pcbi.1009121
Contact tracing efficiency, transmission heterogeneity, and accelerating COVID-19 epidemics
PLOS Computational Biology: published June 17, 2021 | https://doi.org/10.1371/journal.pcbi.1009122
Inhibition of RPS6K reveals context-dependent Akt activity in luminal breast cancer cells
PLOS Computational Biology: published June 30, 2021 | https://doi.org/10.1371/journal.pcbi.1009125
Multidimensional analysis and detection of informative features in human brain white matter
PLOS Computational Biology: published June 28, 2021 | https://doi.org/10.1371/journal.pcbi.1009136
A computational model of pig ventricular cardiomyocyte electrophysiology and calcium handling: Translation from pig to human electrophysiology
PLOS Computational Biology: published June 30, 2021 | https://doi.org/10.1371/journal.pcbi.1009137
Behavioral correlates of cortical semantic representations modeled by word vectors
PLOS Computational Biology: published June 23, 2021 | https://doi.org/10.1371/journal.pcbi.1009138
Adaptation of metabolite leakiness leads to symbiotic chemical exchange and to a resilient microbial ecosystem
PLOS Computational Biology: published June 23, 2021 | https://doi.org/10.1371/journal.pcbi.1009143
Rate-dependent effects of lidocaine on cardiac dynamics: Development and analysis of a low-dimensional drug-channel interaction model
PLOS Computational Biology: published June 29, 2021 | https://doi.org/10.1371/journal.pcbi.1009145
Regulating synchronous oscillations of cerebellar granule cells by different types of inhibition
PLOS Computational Biology: published June 28, 2021 | https://doi.org/10.1371/journal.pcbi.1009163
Simulation of angiogenesis in three dimensions: Application to cerebral cortex
PLOS Computational Biology: published June 25, 2021 | https://doi.org/10.1371/journal.pcbi.1009164
Molecular signatures of silencing suppression degeneracy from a complex RNA virus
PLOS Computational Biology: published June 28, 2021 | https://doi.org/10.1371/journal.pcbi.1009166
Correction
Correction: A new model for simultaneous dimensionality reduction and time-varying functional connectivity estimation
PLOS Computational Biology: published June 8, 2021 | https://doi.org/10.1371/journal.pcbi.1009112