Epileptic seizures are hypersynchronous states disrupting normal brain function unfolding across brain networks. We can now image the network wide changes in brain dynamics using light sheet imaging in the larval zebrafish brain. Combined with computational modelling, this gives us a powerful tool to investigate the connectivity changes that allow these abnormal seizure states to emerge.
Image Credit: Richard Ewald Rosch
Research Articles
Irrelevance by inhibition: Learning, computation, and implications for schizophrenia
PLOS Computational Biology: published August 1, 2018 | https://doi.org/10.1371/journal.pcbi.1006315
Modeling the impact of changes in day-care contact patterns on the dynamics of varicella transmission in France between 1991 and 2015
PLOS Computational Biology: published August 1, 2018 | https://doi.org/10.1371/journal.pcbi.1006334
The permeation mechanism of organic cations through a CNG mimic channel
PLOS Computational Biology: published August 2, 2018 | https://doi.org/10.1371/journal.pcbi.1006295
Profiling cellular morphodynamics by spatiotemporal spectrum decomposition
PLOS Computational Biology: published August 2, 2018 | https://doi.org/10.1371/journal.pcbi.1006321
Rare-event sampling of epigenetic landscapes and phenotype transitions
PLOS Computational Biology: published August 3, 2018 | https://doi.org/10.1371/journal.pcbi.1006336
A mechanism for bistability in glycosylation
PLOS Computational Biology: published August 3, 2018 | https://doi.org/10.1371/journal.pcbi.1006348
A new dynamic correlation algorithm reveals novel functional aspects in single cell and bulk RNA-seq data
PLOS Computational Biology: published August 6, 2018 | https://doi.org/10.1371/journal.pcbi.1006391
Network supporting contextual fear learning after dorsal hippocampal damage has increased dependence on retrosplenial cortex
PLOS Computational Biology: published August 7, 2018 | https://doi.org/10.1371/journal.pcbi.1006207
Network-level allosteric effects are elucidated by detailing how ligand-binding events modulate utilization of catalytic potentials
PLOS Computational Biology: published August 7, 2018 | https://doi.org/10.1371/journal.pcbi.1006356
Phylogeny-corrected identification of microbial gene families relevant to human gut colonization
PLOS Computational Biology: published August 9, 2018 | https://doi.org/10.1371/journal.pcbi.1006242
Flexible resonance in prefrontal networks with strong feedback inhibition
PLOS Computational Biology: published August 9, 2018 | https://doi.org/10.1371/journal.pcbi.1006357
Modeling subjective relevance in schizophrenia and its relation to aberrant salience
PLOS Computational Biology: published August 10, 2018 | https://doi.org/10.1371/journal.pcbi.1006319
Discerning evolutionary trends in post-translational modification and the effect of intrinsic disorder: Analysis of methylation, acetylation and ubiquitination sites in human proteins
PLOS Computational Biology: published August 10, 2018 | https://doi.org/10.1371/journal.pcbi.1006349
scPipe: A flexible R/Bioconductor preprocessing pipeline for single-cell RNA-sequencing data
PLOS Computational Biology: published August 10, 2018 | https://doi.org/10.1371/journal.pcbi.1006361
riboWaltz: Optimization of ribosome P-site positioning in ribosome profiling data
PLOS Computational Biology: published August 13, 2018 | https://doi.org/10.1371/journal.pcbi.1006169
Regulation of Pom cluster dynamics in Myxococcus xanthus
PLOS Computational Biology: published August 13, 2018 | https://doi.org/10.1371/journal.pcbi.1006358
SILGGM: An extensive R package for efficient statistical inference in large-scale gene networks
PLOS Computational Biology: published August 13, 2018 | https://doi.org/10.1371/journal.pcbi.1006369
Scaling up data curation using deep learning: An application to literature triage in genomic variation resources
PLOS Computational Biology: published August 13, 2018 | https://doi.org/10.1371/journal.pcbi.1006390
Interplay of multiple pathways and activity-dependent rules in STDP
PLOS Computational Biology: published August 14, 2018 | https://doi.org/10.1371/journal.pcbi.1006184
Integration and multiplexing of positional and contextual information by the hippocampal network
PLOS Computational Biology: published August 14, 2018 | https://doi.org/10.1371/journal.pcbi.1006320
Accounting for non-stationarity in epidemiology by embedding time-varying parameters in stochastic models
PLOS Computational Biology: published August 15, 2018 | https://doi.org/10.1371/journal.pcbi.1006211
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Characterising seasonal influenza epidemiology using primary care surveillance data
PLOS Computational Biology: published August 16, 2018 | https://doi.org/10.1371/journal.pcbi.1006377
MimicrEE2: Genome-wide forward simulations of Evolve and Resequencing studies
PLOS Computational Biology: published August 16, 2018 | https://doi.org/10.1371/journal.pcbi.1006413
Exploring of the feature space of de novo developed post-transcriptional riboregulators
PLOS Computational Biology: published August 17, 2018 | https://doi.org/10.1371/journal.pcbi.1006170
The role of curvature feedback in the energetics and dynamics of lamprey swimming: A closed-loop model
PLOS Computational Biology: published August 17, 2018 | https://doi.org/10.1371/journal.pcbi.1006324
ggsashimi: Sashimi plot revised for browser- and annotation-independent splicing visualization
PLOS Computational Biology: published August 17, 2018 | https://doi.org/10.1371/journal.pcbi.1006360
How ecological feedbacks between human population and land cover influence sustainability
PLOS Computational Biology: published August 17, 2018 | https://doi.org/10.1371/journal.pcbi.1006389
Unraveling the mechanism of the cadherin-catenin-actin catch bond
PLOS Computational Biology: published August 17, 2018 | https://doi.org/10.1371/journal.pcbi.1006399
Domes and cones: Adhesion-induced fission of membranes by ESCRT proteins
PLOS Computational Biology: published August 21, 2018 | https://doi.org/10.1371/journal.pcbi.1006422
Lineage space and the propensity of bacterial cells to undergo growth transitions
PLOS Computational Biology: published August 22, 2018 | https://doi.org/10.1371/journal.pcbi.1006380
NFTsim: Theory and Simulation of Multiscale Neural Field Dynamics
PLOS Computational Biology: published August 22, 2018 | https://doi.org/10.1371/journal.pcbi.1006387
Inferring hidden structure in multilayered neural circuits
PLOS Computational Biology: published August 23, 2018 | https://doi.org/10.1371/journal.pcbi.1006291
Calcium imaging and dynamic causal modelling reveal brain-wide changes in effective connectivity and synaptic dynamics during epileptic seizures
PLOS Computational Biology: published August 23, 2018 | https://doi.org/10.1371/journal.pcbi.1006375
Dorsal anterior cingulate-brainstem ensemble as a reinforcement meta-learner
PLOS Computational Biology: published August 24, 2018 | https://doi.org/10.1371/journal.pcbi.1006370
coTRaCTE predicts co-occurring transcription factors within cell-type specific enhancers
PLOS Computational Biology: published August 24, 2018 | https://doi.org/10.1371/journal.pcbi.1006372
MDHGI: Matrix Decomposition and Heterogeneous Graph Inference for miRNA-disease association prediction
PLOS Computational Biology: published August 24, 2018 | https://doi.org/10.1371/journal.pcbi.1006418
Identification of excitatory-inhibitory links and network topology in large-scale neuronal assemblies from multi-electrode recordings
PLOS Computational Biology: published August 27, 2018 | https://doi.org/10.1371/journal.pcbi.1006381
General differential Hebbian learning: Capturing temporal relations between events in neural networks and the brain
PLOS Computational Biology: published August 28, 2018 | https://doi.org/10.1371/journal.pcbi.1006227
New methods for computational decomposition of whole-mount in situ images enable effective curation of a large, highly redundant collection of Xenopus images
PLOS Computational Biology: published August 29, 2018 | https://doi.org/10.1371/journal.pcbi.1006077
Corrections
Correction: Limits on reliable information flows through stochastic populations
PLOS Computational Biology: published August 9, 2018 | https://doi.org/10.1371/journal.pcbi.1006404
Related Articles
Correction: Subgraphs of functional brain networks identify dynamical constraints of cognitive control
PLOS Computational Biology: published August 28, 2018 | https://doi.org/10.1371/journal.pcbi.1006420