Figures
Table 1 and Figs 4, 5, 7, 8 and 10 are incorrect. There is an error in the value of the threshold used to calculate the confidence intervals. The authors have provided the corrected versions here.
Best-fit parameters and likelihood-based 95% confidence intervals for the fits of the two-, three-, and four-stage clonal expansion models (with parameterizations using only practically identifiable parameter combinations and given in Eqs. (2), (9), and (11) respectively) to age-specific incidence of pancreatic cancer.
Profiles of the relative negative log-likelihood (NLL) of the two-stage clonal expansion model as each of the parameter combinations p2, q2, and νX/α are varied while the remaining parameters are fit. The gray dotted line gives the α = 0.05 threshold for simultaneous confidence intervals based on the relative negative log-likelihood. All three parameters are identifiable.
Profiles of the relative negative log-likelihood (NLL) of the three-stage clonal expansion model as each of parameter combinations p3, q3, νX, and μ1/α are varied while the remaining parameters are fit. The gray dotted line gives the α = 0.05 threshold for simultaneous confidence intervals based on the relative negative log-likelihood. Parameter combinations p3 and p4 are identifiable, while νX and μ1/α are practically unidentifiable.
Profile of the relative negative log-likelihood (NLL) as the parameter varied while the remaining parameters are fit in the three-stage clonal expansion model. The gray dotted line gives the α = 0.05 threshold for simultaneous confidence intervals based on the relative negative log-likelihood. Parameter combination r3 is identifiable.
Profiles of the relative negative log-likelihood (NLL) of the four-stage clonal expansion model as each of parameter combinations p4, q4, νX, μ1, and μ2/α are varied while the remaining parameters are fit. The gray dotted line gives the α = 0.05 threshold for simultaneous confidence intervals based on the relative negative log-likelihood. Parameter combinations p4 and q4 are identifiable, while νX, μ1, and μ2/α are practically unidentifiable.
Profile of the relative negative log-likelihood (NLL) as the parameter r4 = (νXμ1μ2/α)1/3 is varied while the remaining parameters are fit in the four stage clonal expansion model. The gray dotted line gives the α = 0.05 threshold for simultaneous confidence intervals based on the relative negative log-likelihood. Parameter combination r4 is identifiable.
Reference
- 1. Brouwer AF, Meza R, Eisenberg MC (2017) Parameter estimation for multistage clonal expansion models from cancer incidence data: A practical identifiability analysis. PLOS Computational Biology 13(3): e1005431. https://doi.org/10.1371/journal.pcbi.1005431 pmid:28288156
Citation: Brouwer AF, Meza R, Eisenberg MC (2017) Correction: Parameter estimation for multistage clonal expansion models from cancer incidence data: A practical identifiability analysis. PLoS Comput Biol 13(7): e1005660. https://doi.org/10.1371/journal.pcbi.1005660
Published: July 17, 2017
Copyright: © 2017 Brouwer et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.