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Inference of B cell clonal families using heavy/light chain pairing information

Fig 10

Resolving discrepancies for one cluster between the heavy and light partitions (left) and incorporating a (different) group of resolved clusters into the final partition (right).

Left: After selecting a single cluster C_l from one partition, we then take all clusters from the other partition (the ) that contain any of the same three sequences a, b, and c. We then determine how C_l should be split apart using the , and finish with the resulting “resolved” clusters . Right: After several rounds of discrepancy resolution, we have a partially complete final partition P_f into which we must incorporate each new group of resolved clusters . We do this by removing common sequences from the larger of any two clusters that share sequences (regardless of whether the larger cluster is in P_f or in ). In this case, this means we remove the e from de in P_f, as well as removing the f from ef in .

doi: https://doi.org/10.1371/journal.pcbi.1010723.g010