Inference of B cell clonal families using heavy/light chain pairing information
Fig 4
Effectiveness on simulation of the pair info cleaning method as a function of true family size, shown as the fraction of sequences correctly paired (top left); and the fraction not correctly paired, split into those mispaired (bottom left) and left unpaired (bottom right). We also show the fraction that are paired with a sequence from the correct family, though not necessarily the correct sequence from that family (top right). Each point is the mean (± standard error, often smaller than points) over three samples, each consisting of 3,000 simulated rearrangement events (around 12,000 total heavy and light sequences). The family sizes are drawn from a distribution inferred from real data. The effects of a variety of cluster size distributions on performance are shown in S8 Fig, in terms of both fraction correctly paired and of final clustering accuracy.