Maintaining maximal metabolic flux by gene expression control
Fig 6
qORAC for an internal parameter.
In this example qORAC is illustrated for a Km parameter in the third reaction, K3. In A the same pathway is drawn, with sensors in blue. B: metabolite dynamics in which first external concentrations are varied (green) and at the end also K3 is varied. C: K3 (in green) is varied at time t = 2500, and the predicted optimal value (in orange) subsequently converges, illustrating robust adaptive control. An example in which the same pathway is controlled using a different set of sensors, resulting in lack of convergence to the optimum, is found in the SI, S4 Fig.