Maintaining maximal metabolic flux by gene expression control
Fig 5
Example dynamics for a more complicated pathway.
A: metabolic network with two inputs and two outputs, and with allosteric cross-inhibition. This pathway is robust to changes in both input and output concentration (in green), which requires four sensors (in blue). B: Each of the external concentrations is changed once, and the system adapts accordingly. C: the metabolite concentrations converge to the (periodically changing) predicted optimum over time. D: enzyme concentration dynamics. See SI text for details of the pathway, and the matlab file daes_double_branched.m for the code.