Effects of Darwinian Selection and Mutability on Rate of Broadly Neutralizing Antibody Evolution during HIV-1 Infection
Fig 1
Study periods of the VRC26, CH103, and VRC01 lineages.
To study the dynamics of evolutionary rate, selection pressure and mutability over time, we separated the time points of a lineage into two or three stages. (A) Time points of the CAP256-VRC26 lineage for which curated antibody variable region sequences were available. The eight time points were divided into three stages, which are listed above the time scale. (B) Time points of the CH103 lineage, with sequence data available at three time points, which were divided to two stages. (C). Study period of the VRC01 lineage. Since the exact date of HIV-1 infection is unavailable for this donor, the infection period before VRC01 lineage study initiation was represented with a dashed line. The approximate lineage initiation times for the VRC26 and CH103 lineages were labeled with red boxes.