An Integrated Framework Advancing Membrane Protein Modeling and Design
Fig 8
Assembly of symmetric protein complexes in the membrane using MPsymdock.
(A) FoldTree representation of the homo-tetrameric KcsA potassium channel with the membrane residue (M) at the root (circled). The virtual residues V1,i and V2,i required for the symmetry machinery are described in the text. (B) Native structure in gray (PDB 1bl8) superimposed with the model from MPsymdock with the lowest interface score. The view is from the extracellular side of the membrane. (C) Membrane plane view of (B). (D) Interface score vs. backbone RMSD to the native structure for 1000 models of the KcsA potassium channel. The lowest scoring model, shown in (B) and (C), is indicated in red.