Interpreting Metabolomic Profiles using Unbiased Pathway Models
Figure 3
Proposed mechanism for coupling of methionine influx to SLC6A12 transport of glycine betaine and dimethylglycine for osmoregulation.
The connections among the 3 metabolites (and proline) in the NGT-EMRN and NGT-CMRN AMGs are shown, along with the Recon 1 betaine-homocysteine methyltransferase catalyzed reaction.